The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Intracellular Bacterial Biofilm-Like Pods in Urinary Tract Infections
Abstract
Escherichia coli entry into the bladder is met with potent innate defenses, including neutrophil influx and epithelial exfoliation. Bacterial subversion of innate responses involves invasion into bladder superficial cells. We discovered that the intracellular bacteria matured into biofilms, creating pod-like bulges on the bladder surface. Pods contained bacteria encased in a polysaccharide-rich matrix surrounded by a protective shell of uroplakin. Within the biofilm, bacterial structures interacted extensively with the surrounding matrix, and biofilm associated factors had regional variation in expression. The discovery of intracellular biofilm-like pods explains how bladder infections can persist in the face of robust host defenses.
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Citations
Cites
Biofilms: Survival Mechanisms of Clinically Relevant Microorganisms
Donlan, R. M., & Costerton, J. W. (2002) · Clinical Microbiology Reviews · doi:10.1128/cmr.15.2.167-193.2002 · Cited by 6,644
Cited by
Kaper, J. B., Nataro, J. P., & Mobley, H. L. T. (2004) · Nature Reviews Microbiology · doi:10.1038/nrmicro818 · Cited by 5,583
Wolfe, A. J. (2005) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.69.1.12-50.2005 · Cited by 1,233
Bacterial Adhesion and Entry into Host Cells
Pizarro-Cerdá, J., & Cossart, P. (2006) · Cell · doi:10.1016/j.cell.2006.02.012 · Cited by 977
“Cdc42 and RhoA are also required for the FimH-dependent cell invasion process by UPEC (Martinez and Hultgren, 2002).”
InfluentialThe biology and future prospects of antivirulence therapies
Cegelski, L., Marshall, G. R., Eldridge, G. R., & Hultgren, S. J. (2008) · Nature Reviews Microbiology · doi:10.1038/nrmicro1818 · Cited by 788
Self-citationDetection of Intracellular Bacterial Communities in Human Urinary Tract Infection
Rosen, D. A., Hooton, T. M., Stamm, W. E., Humphrey, P. A., & Hultgren, S. J. (2007) · PLoS Medicine · doi:10.1371/journal.pmed.0040329 · Cited by 651
“This intracellular niche is conducive to UPEC replication and formation of intracellular bacterial communities (IBCs) with biofilm-like properties [13].”
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Metadata
- Authors
- Anderson, G. G., Palermo, J. J., Schilling, J. D., Roth, R., Heuser, J., & Hultgren, S. J.
- Venue
- Science
- Published
- 2003-07-04
- Volume
- 301
- Issue
- 5629
- Pages
- 105-107
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2124772160
- Cited by
- 1,161
- References
- 1
- FWCI
- 12.98
- Type
- journal article
- Language
- en
- Open access
- closed
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- Anderson, G. G., Palermo, J. J., Schilling, J. D., Roth, R., Heuser, J., & Hultgren, S. J. (2003). Intracellular Bacterial Biofilm-Like Pods in Urinary Tract Infections. Science. https://doi.org/10.1126/science.1084550
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
