Pathogenic Escherichia coli
Abstract
Few microorganisms are as versatile as Escherichia coli. An important member of the normal intestinal microflora of humans and other mammals, E. coli has also been widely exploited as a cloning host in recombinant DNA technology. But E. coli is more than just a laboratory workhorse or harmless intestinal inhabitant; it can also be a highly versatile, and frequently deadly, pathogen. Several different E. coli strains cause diverse intestinal and extraintestinal diseases by means of virulence factors that affect a wide range of cellular processes.
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The K1 capsular type is the most common capsular type reported in newborns, causing up to 80% of cases of meningitis.
“While this is the most common capsular type reported in newborns, causing up to 80% of cases of meningitis, other E. coli types are known to cause infections of the CNS (45).”
From Multicenter Evaluation of BioFire FilmArray Meningitis/Encephalitis Panel for Detection of Bacteria, Viruses, and Yeast in Cerebrospinal Fluid Specimens (2016) · cites this paper as [45]
Other E. coli types are known to cause infections of the CNS.
“While this is the most common capsular type reported in newborns, causing up to 80% of cases of meningitis, other E. coli types are known to cause infections of the CNS (45).”
From Multicenter Evaluation of BioFire FilmArray Meningitis/Encephalitis Panel for Detection of Bacteria, Viruses, and Yeast in Cerebrospinal Fluid Specimens (2016) · cites this paper as [45]
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“1a ((1)3) tsh (1) cvaC (4) ibeA (11) iroN (18) vat (17) sfaH (9) hek (14) hlyA (12) cnf1 (11) papGIII (11) ompT (41) feoB (60) fimH (54) traT (18) fyuA (30) irp2 (30) malX (26) chuA (31) sit (21) usp (21) bmaE (0) draB (0) picU (7) iha (17) iucC (16) iutA (16) focH (3) cdtB (4) sat (4) ireA (6) papGII (7)”
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“…E. coli (EPEC), enteroinvasive E. coli (EIEC), enterotoxigenic E. coli (ETEC), enterohemorrhagic E. coli (EHEC), enteroaggregative E. coli (EAEC), diffusely-adherent E. coli (DAEC), and adherentinvasive E. coli (AIEC) (Nataro and Kaper, 1998; Kaper et al., 2004; Croxen et al., 2013).”
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Self-citationRecent Updates on Outbreaks of Shiga Toxin-Producing Escherichia coli and Its Potential Reservoirs
Kim, J., Lee, M., & Kim, J. H. (2020) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2020.00273 · Cited by 183 · see citing works
“Based on its pathotypes, intestinal pathogenic E. coli can be classified into six groups: Shiga toxin (Stx)-producing [STEC, also referred to as verocytotoxin-producing (VTEC) or enterohemorrhagic (EHEC)], enterotoxigenic (ETEC), enteropathogenic (EPEC), enteroaggregative (EAEC), enteroinvasive (EIEC), and diffusely a…”
BackgroundThe ins and outs of siderophore mediated iron uptake by extra-intestinal pathogenic Escherichia coli
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Electrochemical Biosensors in Food Safety: Challenges and Perspectives
Curulli, A. (2021) · Molecules · doi:10.3390/molecules26102940 · Cited by 142
“coli are among the major causes of illness in many developing countries [110], causing gastroenteritis and related diseases leading to dramatic consequences [111].”
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“coli (EHEC) pathotype is involved worldwide inmany outbreaks, severe symptomatology, and lethal outcomes to the human host (Levine, 1987; Kaper et al., 2004; Croxen et al., 2013; Gomes et al., 2016).”
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The interaction between the gut Microbiota and herbal medicines
An, X., Bao, Q. D., Di, S., Zhao, Y. C., Zhao, S., Zhang, H., Lian, F., & Tong, X. (2019) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2019.109252 · Cited by 166 · see citing works
Interplay between Siderophores and Colibactin Genotoxin Biosynthetic Pathways in Escherichia coli
Martin, P., Marcq, I., Magistro, G., Penary, M., Garcie, C., Payros, D., Boury, M., Olier, M., Nougayrède, J.-P., Audebert, M., et al. (2013) · PLoS Pathogens · doi:10.1371/journal.ppat.1003437 · Cited by 138 · see citing works
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How CRISPR-Cas System Could Be Used to Combat Antimicrobial Resistance
Gholizadeh, P., Köse, Ş., Dao, S., Ganbarov, K., Tanomand, A., Dal, T., Aghazadeh, M. H., Ghotaslou, R., Rezaee, M. A., Yousefi, B., et al. (2020) · Infection and Drug Resistance · doi:10.2147/idr.s247271 · Cited by 170 · see citing works
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“These allow UPEC to infect an immunocompetent host, as they encode for factors enabling it to colonize the periurethral area and ascend the urethra to the bladder [7].”
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The burden of hospital acquired infections and antimicrobial resistance
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“The commensal form inhabits the gastrointestinal tract of humans aiding in digestion [43], whiles the pathogenic forms cause infections resulting in two million deaths annually [44].”
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Acetate metabolism regulation in Escherichia coli: carbon overflow, pathogenicity, and beyond
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“Further pathotypes have been described in animals (Kaper et al. 2004).”
The bacterial biota of laboratory-reared edible mealworms (Tenebrio molitor L.): From feed to frass.
Osimani, A., Milanović, V., Cardinali, F., Garofalo, C., Clementi, F., Pasquini, M., Riolo, P., Ruschioni, S., Isidoro, N., Loreto, N., et al. (2018) · Journal of food microbiology · doi:10.1016/j.ijfoodmicro.2018.03.001 · Cited by 120 · see citing works
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Taxonomic signatures of cause-specific mortality risk in human gut microbiome
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“EPEC attaches to and colonizes the intestinal tract by inducing characteristic “attaching and effacing” (A/E) lesions on the intestinal epithelium (Kaper et al., 2004; Mundy et al., 2005).”
BackgroundImmunogenicity of bacteriophages
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Review of major meat-borne zoonotic bacterial pathogens
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“Moreover, Shiga toxins (Stxs) and lipopolysaccharides (LPS) derived from ETEC are also involved in the pathogenicity in the host (13).”
Background
- Authors
- Kaper, J. B., Nataro, J. P., & Mobley, H. L. T.
- Affiliations
- University of Maryland, Baltimore (US)
- Corresponding author
- Kaper, James B.
- Venue
- Nature Reviews Microbiology
- Published
- 2004-02
- Volume
- 2
- Issue
- 2
- Pages
- 123-140
- ISSN
- 1740-1526 (ISSN-L)
- 1740-1534
- OpenAlex
- W1966597734
- Cited by
- 5,583
- References
- 0
- Citations by year
- 2026: 269 · 2025: 345 · 2024: 385 · 2023: 396 · 2022: 458 · 2021: 329 · 2020: 310 · 2019: 268 · 2018: 256 · 2017: 284 · 2016: 276 · 2015: 298 · 2014: 301 · 2013: 245 · 2012: 244
- FWCI
- 8.88
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Nature Reviews Microbiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Allergy and Infectious Diseases (R37AI021657)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Escherichia coli research studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Enterobacteriaceae and Cronobacter Research
- Keywords
- pathogenic Escherichia coli, virulence factors, extraintestinal infections, intestinal diseases, bacterial pathogenesis, host-pathogen interaction, enteric pathogens
- MeSH terms
- Animals, Bacterial Adhesion, Diarrhea, Escherichia coli, Humans, Urinary Tract Infections, Gene Expression Regulation, Bacterial, Meningitis, Bacterial, Shiga Toxins, Virulence Factors
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