The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.
Dual Activation of the Drosophila Toll Pathway by Two Pattern Recognition Receptors
Abstract
The Toll- dependent defense against Gram-positive bacterial infections in Drosophila is mediated through the peptidoglycan recognition protein SA (PGRP-SA). A mutation termed osiris disrupts the Gram-negative binding protein 1 ( GNBP1 ) gene and leads to compromised survival of mutant flies after Gram-positive infections, but not after fungal or Gram-negative bacterial challenge. Our results demonstrate that GNBP1 and PGRP-SA can jointly activate the Toll pathway. The potential for a combination of distinct proteins to mediate detection of infectious nonself in the fly will refine the concept of pattern recognition in insects.
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The Pfam Protein Families Database
Bateman, A. (2002) · Nucleic Acids Research · doi:10.1093/nar/30.1.276 · Cited by 14,000
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Self-citationApproaching the Asymptote? Evolution and Revolution in Immunology
Janeway, C. A. (1989) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.1989.054.01.003 · Cited by 3,252
Drosophila innate immunity: an evolutionary perspective
Hoffmann, J. A., & Reichhart, J.-M. (2002) · Nature Immunology · doi:10.1038/ni0202-121 · Cited by 1,142
Self-citationLemaitre, B., Reichhart, J.-M., & Hoffmann, J. A. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.26.14614 · Cited by 1,034
Self-citationThe Toll and Imd pathways are the major regulators of the immune response in Drosophila
De Gregorio, E. (2002) · The EMBO Journal · doi:10.1093/emboj/21.11.2568 · Cited by 934
Michel, T., Reichhart, J.-M., Hoffmann, J. A., & Royet, J. (2001) · Nature · doi:10.1038/414756a · Cited by 796
Self-citationGottar, M., Gobert, V., Michel, T., Belvin, M., Duyk, G., Hoffmann, J. A., Ferrandon, D., & Royet, J. (2002) · Nature · doi:10.1038/nature734 · Cited by 691
Self-citationGenome-wide analysis of the Drosophila immune response by using oligonucleotide microarrays
De Gregorio, E., Spellman, P. T., Rubin, G. M., & Lemaitre, B. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.221458698 · Cited by 691
Binding of the Drosophila cytokine Spätzle to Toll is direct and establishes signaling
Weber, A. N. R., Tauszig-Delamasure, S., Hoffmann, J. A., Lelièvre, E., Gascan, H., Ray, K. P., Morse, M. A., Imler, J.-L., & Gay, N. J. (2003) · Nature Immunology · doi:10.1038/ni955 · Cited by 469
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Cited by
Toll-like receptors in innate immunity
Takeda, K. (2004) · International Immunology · doi:10.1093/intimm/dxh186 · Cited by 3,328
The Host Defense of Drosophila melanogaster
Lemaitre, B., & Hoffmann, J. (2007) · Annual Review of Immunology · doi:10.1146/annurev.immunol.25.022106.141615 · Cited by 3,324
Self-citationThe Drosophila Toll Signaling Pathway
Valanne, S., Wang, J.-H., & Rämet, M. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1002302 · Cited by 894
Immunity in Drosophila melanogaster — from microbial recognition to whole-organism physiology
Buchon, N., Silverman, N., & Cherry, S. (2014) · Nature Reviews Immunology · doi:10.1038/nri3763 · Cited by 866
Recent Advances in the Innate Immunity of Invertebrate Animals
Iwanaga, S., & Lee, B.-L. (2005) · BMB Reports · doi:10.5483/bmbrep.2005.38.2.128 · Cited by 756
Metadata
- Authors
- Gobert, V., Gottar, M., Matskevich, A. A., Rutschmann, S., Royet, J., Belvin, M., Hoffmann, J. A., & Ferrandon, D.
- Venue
- Science
- Published
- 2003-12-19
- Volume
- 302
- Issue
- 5653
- Pages
- 2126-2130
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2124786856
- Cited by
- 411
- References
- 25
- FWCI
- 8.32
- Type
- journal article
- Language
- en
- Open access
- closed
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- Gobert, V., Gottar, M., Matskevich, A. A., Rutschmann, S., Royet, J., Belvin, M., Hoffmann, J. A., & Ferrandon, D. (2003). Dual Activation of the Drosophila Toll Pathway by Two Pattern Recognition Receptors. Science. https://doi.org/10.1126/science.1085432
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