The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.
Resurrecting the Ancestral Steroid Receptor: Ancient Origin of Estrogen Signaling
Abstract
Receptors for sex and adrenal steroid hormones are absent from fully sequenced invertebrate genomes and have not been recovered from other invertebrates. Here we report the isolation of an estrogen receptor ortholog from the mollusk Aplysia californica and the reconstruction, synthesis, and experimental characterization of functional domains of the ancestral protein from which all extant steroid receptors (SRs) evolved. Our findings indicate that SRs are extremely ancient and widespread, having diversified from a primordial gene before the origin of bilaterally symmetric animals, and that this ancient receptor had estrogen receptor–like functionality. This gene was lost in the lineage leading to arthropods and nematodes and became independent of hormone regulation in the Aplysia lineage.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
An Empirical Test of Bootstrapping as a Method for Assessing Confidence in Phylogenetic Analysis
Hillis, D. M., & Bull, J. J. (1993) · Systematic Biology · doi:10.1093/sysbio/42.2.182 · Cited by 3,631
An Empirical Test of Bootstrapping as a Method for Assessing Confidence in Phylogenetic Analysis
Hillis, D. M., & Bull, J. J. (1993) · Systematic Biology · doi:10.2307/2992540 · Cited by 3,423
Nilsson, S., Mäkelä, S., Treuter, E., Tujague, M., Thomsen, J., Andersson, G., Enmark, E., Pettersson, K., Warner, M., & Gustafsson, J.-Å. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.4.1535 · Cited by 1,996
The Draft Genome of Ciona intestinalis : Insights into Chordate and Vertebrate Origins
Dehal, P., Satou, Y., Campbell, R. K., Chapman, J., Degnan, B., De Tomaso, A., Davidson, B., Di Gregorio, A., Gelpke, M., Goodstein, D. M., et al. (2002) · Science · doi:10.1126/science.1080049 · Cited by 1,641
Thornton, J. W. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.091553298 · Cited by 681
Self-citationOvercredibility of molecular phylogenies obtained by Bayesian phylogenetics
Suzuki, Y., Glazko, G. V., & Nei, M. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.212646199 · Cited by 647
Peterson, K. J., & Eernisse, D. J. (2001) · Evolution & Development · doi:10.1046/j.1525-142x.2001.003003170.x · Cited by 529
Oestradiol induction of a glucocorticoid-responsive gene by a chimaeric receptor
Green, S., & Chambon, P. (1987) · Nature · doi:10.1038/325075a0 · Cited by 431
Ligand binding was acquired during evolution of nuclear receptors
Escriva, H., Safi, R., Hänni, C., Langlois, M.-C., Saumitou-Laprade, P., Stehelin, D., Capron, A., Pierce, R., & Laudet, V. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.13.6803 · Cited by 403
To ERR in the estrogen pathway
Giguére, V. (2002) · Trends in Endocrinology & Metabolism · doi:10.1016/s1043-2760(02)00592-1 · Cited by 401
Cited by
Estrogen receptors: how do they signal and what are their targets
Heldring, N., Pike, A., Andersson, S., Matthews, J., Cheng, G., Hartman, J., Tujague, M., Ström, A., Treuter, E., Warner, M., et al. (2007) · Physiological Reviews · doi:10.1152/physrev.00026.2006 · Cited by 1,857
Enzyme promiscuity: A mechanistic and evolutionary perspective
Tawfik, O. K. A. D. S. (2010) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-030409-143718 · Cited by 1,355
The role of estrogens in control of energy balance and glucose homeostasis
Mauvais-Jarvis, F., Clegg, D. J., & Hevener, A. L. (2013) · Endocrine Reviews · doi:10.1210/er.2012-1055 · Cited by 1,329
Turning a hobby into a job: How duplicated genes find new functions
Conant, G. C., & Wolfe, K. H. (2008) · Nature Reviews Genetics · doi:10.1038/nrg2482 · Cited by 1,281
Enzyme promiscuity: evolutionary and mechanistic aspects
Khersonsky, O., Roodveldt, C., & Tawfik, D. S. (2006) · Current Opinion in Chemical Biology · doi:10.1016/j.cbpa.2006.08.011 · Cited by 641
Metadata
- Authors
- Thornton, J. W., Need, E., & Crews, D.
- Venue
- Science
- Published
- 2003-09-19
- Volume
- 301
- Issue
- 5640
- Pages
- 1714-1717
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1982607030
- Cited by
- 699
- References
- 17
- FWCI
- 21.27
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Resurrecting the Ancestral Steroid Receptor: Ancient Origin of Estrogen Signaling. https://app.cochat.ai/papers/10.1126/science.1086185
- The paper
- Thornton, J. W., Need, E., & Crews, D. (2003). Resurrecting the Ancestral Steroid Receptor: Ancient Origin of Estrogen Signaling. Science. https://doi.org/10.1126/science.1086185
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
