The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Talin Binding to Integrin ß Tails: A Final Common Step in Integrin Activation
Abstract
Control of integrin affinity for ligands (integrin activation) is essential for normal cell adhesion, migration, and assembly of an extracellular matrix. Integrin activation is usually mediated through the integrin β subunit cytoplasmic tail and can be regulated by many different biochemical signaling pathways. We report that specific binding of the cytoskeletal protein talin to integrin β subunit cytoplasmic tails leads to the conformational rearrangements of integrin extracellular domains that increase their affinity. Thus, regulated binding of talin to integrin β tails is a final common element of cellular signaling cascades that control integrin activation.
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Hynes (2002) · doi:10.1016/s0092-8674(02)00971-6 · Cited by 8,606
Calderwood, D. A., Zent, R., Grant, R., Rees, D. J. G., Hynes, R. O., & Ginsberg, M. H. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.40.28071 · Cited by 720
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Metadata
- Authors
- Tadokoro, S., Shattil, S. J., Eto, K., Tai, V., Liddington, R. C., de Pereda, J. M., Ginsberg, M. H., & Calderwood, D. A.
- Venue
- Science
- Published
- 2003-10-03
- Volume
- 302
- Issue
- 5642
- Pages
- 103-106
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2040379229
- Cited by
- 1,209
- References
- 2
- FWCI
- 27.87
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Talin Binding to Integrin ß Tails: A Final Common Step in Integrin Activation. https://app.cochat.ai/papers/10.1126/science.1086652
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- Tadokoro, S., Shattil, S. J., Eto, K., Tai, V., Liddington, R. C., de Pereda, J. M., Ginsberg, M. H., & Calderwood, D. A. (2003). Talin Binding to Integrin ß Tails: A Final Common Step in Integrin Activation. Science. https://doi.org/10.1126/science.1086652
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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