The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Structural Basis of a Phototropin Light Switch
Abstract
Phototropins are light-activated kinases important for plant responses to blue light. Light initiates signaling in these proteins by generating a covalent protein–flavin mononucleotide (FMN) adduct within sensory Per-ARNT-Sim (PAS) domains. We characterized the light-dependent changes of a phototropin PAS domain by solution nuclear magnetic resonance spectroscopy and found that an α helix located outside the canonical domain plays a key role in this activation process. Although this helix associates with the PAS core in the dark, photoinduced changes in the domain structure disrupt this interaction. We propose that this mechanism couples light-dependent bond formation to kinase activation and identifies a signaling pathway conserved among PAS domains.
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Cites
Protein backbone angle restraints from searching a database for chemical shift and sequence homology
Cornilescu, G., Delaglio, F., & Bax, A. (1999) · Journal of Biomolecular NMR · doi:10.1023/a:1008392405740 · Cited by 2,957
Phototropins 1 and 2: versatile plant blue-light receptors
Briggs, W. R., & Christie, J. M. (2002) · Trends in Plant Science · doi:10.1016/s1360-1385(02)02245-8 · Cited by 785
Cellular and Subcellular Localization of Phototropin 1
Sakamoto, K., & Briggs, W. R. (2002) · The Plant Cell · doi:10.1105/tpc.003293 · Cited by 405
Cited by
A genetically encoded photoactivatable Rac controls the motility of living cells
Wu, Y. I., Frey, D., Lungu, O. I., Jaehrig, A., Schlichting, I., Kuhlman, B., & Hahn, K. M. (2009) · Nature · doi:10.1038/nature08241 · Cited by 1,083
Phototropin Blue-Light Receptors
Christie, J. M. (2007) · Annual Review of Plant Biology · doi:10.1146/annurev.arplant.58.032806.103951 · Cited by 937
Light-Regulated Plant Growth and Development
Kami, C., Lorrain, S., Hornitschek, P., & Fankhauser, C. (2010) · Current Topics in Developmental Biology · doi:10.1016/s0070-2153(10)91002-8 · Cited by 927
Inter-kingdom signalling: Communication between bacteria and their hosts
Hughes, D. T., & Sperandio, V. (2008) · Nature Reviews Microbiology · doi:10.1038/nrmicro1836 · Cited by 761
Structure and function of plant photoreceptors
Möglich, A., Yang, X., Ayers, R. A., & Moffat, K. (2010) · Annual Review of Plant Biology · doi:10.1146/annurev-arplant-042809-112259 · Cited by 499
Metadata
- Authors
- Harper, S. M., Neil, L. C., & Gardner, K. H.
- Venue
- Science
- Published
- 2003-09-12
- Volume
- 301
- Issue
- 5639
- Pages
- 1541-1544
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2003001669
- Cited by
- 767
- References
- 3
- FWCI
- 32.50
- Type
- journal article
- Language
- en
- Open access
- closed
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- Harper, S. M., Neil, L. C., & Gardner, K. H. (2003). Structural Basis of a Phototropin Light Switch. Science. https://doi.org/10.1126/science.1086810
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
