Inter-kingdom signalling: Communication between bacteria and their hosts
Open accessAbstract
Microorganisms and their hosts communicate with each other through an array of hormonal signals. This cross-kingdom cell-to-cell signalling involves small molecules, such as hormones that are produced by eukaryotes and hormone-like chemicals that are produced by bacteria. Cell-to-cell signalling between bacteria, usually referred to as quorum sensing, was initially described as a means by which bacteria achieve signalling in microbial communities to coordinate gene expression within a population. Recent evidence shows, however, that quorum-sensing signalling is not restricted to bacterial cell-to-cell communication, but also allows communication between microorganisms and their hosts.
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Many microorganisms express receptors for eukaryotic hormonal signals that primarily act by regulating gene expression; for example, when exposed to norepinephrine, Campylobacter jejuni exhibits increased growth and virulence-associated properties in vitro.
“Known as inter-kingdom signaling, many microorganisms express receptors for eukaryotic hormonal signals that primarily act by regulating gene expression [63], e.g., when exposed to norepinephrine, Campylobacter jejuni exhibited increased growth and virulence-associated properties in vitro [64].”
Autoinducer 3 binds to the bacterial membrane receptor QseC, which results in its autophosphorylation; QseC then phosphorylates its response regulator QseB to initiate a signaling cascade that activates expression of bacterial genes associated with virulence and motility, including the gene that presides over flagellum development.
“Autoinducer 3 binds to the bacterial membrane receptor QseC, which results in its autophosphorylation. QseC then phosphorylates its response regulator, QseB, to initiate a complex signaling cascade that activates the expression of bacterial genes associated with virulence and motility, including the gene that presides over flagellum development.34”
From Principles and clinical implications of the brain-gut-enteric microbiota axis (2009) · cites this paper as [34]
In vitro norepinephrine stimulates the growth of several strains of enteric pathogens and magnifies the virulent properties of Campylobacter jejuni.
“In vitro norepinephrine stimulates the growth of several strains of enteric pathogens (reviewed elsewhere34) and magnifies the virulent properties of Campylobacter jejuni.36”
From Principles and clinical implications of the brain-gut-enteric microbiota axis (2009) · cites this paper as [34]
The best-characterized microbial signaling system is analogous to the eukaryotic noradrenergic signaling system and involves autoinducer 3 and the bacterial QseC receptor.
“Perhaps the best-characterized microbial signaling system is analogous to the eukaryotic, noradrenergic signaling system and involves autoinducer 3—a molecule produced by the microbiota and the bacterial QseC receptor.34,44”
From Principles and clinical implications of the brain-gut-enteric microbiota axis (2009) · cites this paper as [34]
Both norepinephrine and dynorphins are thought to be released into the gut lumen during perturbation of homeostasis.
“Both norepinephrine and dynorphins are thought to be released into the gut lumen during perturbation of homeostasis.34”
From Principles and clinical implications of the brain-gut-enteric microbiota axis (2009) · cites this paper as [34]
Similar host-to-enteric-bacteria signaling mechanisms are likely to apply to molecules such as serotonin, somatostatin, cholecystokinin or corticotropin-releasing hormone.
“Even though such host to enteric bacteria signaling has only been character ized in detail for pathogenic organisms, and only for some molecules (such as norepinephrine, dynorphins and cytokines),34 similar mechanisms are likely to apply to molecules such as serotonin, somato statin, cholecysto kinin or corticotropin-releasing hormone.”
From Principles and clinical implications of the brain-gut-enteric microbiota axis (2009) · cites this paper as [34]
Signaling via α-2 adrenergic receptors has been suggested as a mechanism by which certain pathogenic bacteria could inhibit intestinal secretion, and thereby compromise the host's ability to expel the pathogen.
“Signaling via α-2 adrenergic receptors has been suggested as a mechanism by which certain pathogenic bacteria could inhibit intestinal secretion, and thereby compromise the host’s ability to expel the pathogen.34”
From Principles and clinical implications of the brain-gut-enteric microbiota axis (2009) · cites this paper as [34]
That signaling molecules are released by the host into the lumen of the gastrointestinal tract during stress and that receptors and intercellular signaling mechanisms for these same molecules are present on certain luminal microbes strongly suggests that the nervous system can also directly modulate microbial behavior.
“That signaling molecules are released by the host into the lumen of the gastrointestinal tract during stress and that receptors and intercellular signaling mechanisms for these same molecules are present on certain luminal microbes34 strongly suggests that the nervous system can also directly modulate microbial behavior.”
From Principles and clinical implications of the brain-gut-enteric microbiota axis (2009) · cites this paper as [34]
Stress-induced increases in norepinephrine levels in the lumen of the gut may result in increased virulence of certain pathogenic organisms, including Campylobacter jejuni, Salmonella and E. coli, which result in a prolongation of the symptoms of enteritis.
“As discussed above, stress-induced increases in norepi nephrine levels in the lumen of the gut may result in increased virulence of certain pathogenic organisms, including Campylobacter jejuni,36Salmonella82 and E. coli,34 which result in a prolongation of the symptoms of enteritis.”
From Principles and clinical implications of the brain-gut-enteric microbiota axis (2009) · cites this paper as [34]
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Cites
Commensal Host-Bacterial Relationships in the Gut
Hooper, L. V., & Gordon, J. I. (2001) · Science · doi:10.1126/science.1058709 · Cited by 2,362 · see citing works
Quorum-sensing signals indicate that cystic fibrosis lungs are infected with bacterial biofilms
Singh, P. K., Schaefer, A. L., Parsek, M. R., Moninger, T. O., Welsh, M. J., & Greenberg, E. P. (2000) · Nature · doi:10.1038/35037627 · Cited by 1,519 · see citing works
Cellular Control of the Synthesis and Activity of the Bacterial Luminescent System
Nealson, K. H., Platt, T., & Hastings, J. W. (1970) · Journal of Bacteriology · doi:10.1128/jb.104.1.313-322.1970 · Cited by 1,301 · see citing works
Enteropathogenic E. coli (EPEC) transfers its receptor for intimate adherence into mammalian cells.
Kenny, B., Devinney, R., Stein, M., Reinscheid, D., Frey, E., & Finlay, B. (1997) · Cell · doi:10.1016/s0092-8674(00)80437-7 · Cited by 1,258 · see citing works
A genetic locus of enterocyte effacement conserved among diverse enterobacterial pathogens.
McDaniel, T. K., Jarvis, K. G., Donnenberg, M. S., & Kaper, J. B. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.5.1664 · Cited by 1,247 · see citing works
Fuqua, C., Winans, S. C., & Greenberg, E. P. (1996) · Annual Review of Microbiology · doi:10.1146/annurev.micro.50.1.727 · Cited by 1,217 · see citing works
Jerse, A. E., Yu, J., Tall, B. D., & Kaper, J. B. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.20.7839 · Cited by 1,125 · see citing works
Molecular Basis of Symbiotic Promiscuity
Perret, X., Staehelin, C., & Broughton, W. J. (2000) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.64.1.180-201.2000 · Cited by 1,040 · see citing works
The PAS Superfamily: Sensors of Environmental and Developmental Signals
Gu, Y.-Z., Hogenesch, J. B., & Bradfield, C. A. (2000) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.40.1.519 · Cited by 1,023 · see citing works
Bacteria–host communication: the language of hormones
Sperandio, V., Torres, A. G., Jarvis, B., Nataro, J. P., & Kaper, J. B. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1537100100 · Cited by 902 · see citing works
Self-citationTypes of neurons in the enteric nervous system
Furness, J. B. (2000) · Journal of the Autonomic Nervous System · doi:10.1016/s0165-1838(00)00127-2 · Cited by 855 · see citing works
Moon, H. W., Whipp, S. C., Argenzio, R. A., Levine, M. M., & Giannella, R. A. (1983) · Infection and Immunity · doi:10.1128/iai.41.3.1340-1351.1983 · Cited by 846 · see citing works
Structural Basis of a Phototropin Light Switch
Harper, S. M., Neil, L. C., & Gardner, K. H. (2003) · Science · doi:10.1126/science.1086810 · Cited by 768 · see citing works
Draganov, D. I., Teiber, J. F., Speelman, A., Osawa, Y., Sunahara, R. K., & Du, B. N. L. (2005) · Journal of Lipid Research · doi:10.1194/jlr.m400511-jlr200 · Cited by 716 · see citing works
Jarvis, K. G., Girón, J. A., Jerse, A. E., McDaniel, T. K., Donnenberg, M. S., & Kaper, J. B. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.17.7996 · Cited by 626 · see citing works
The QseC sensor kinase: A bacterial adrenergic receptor
Clarke, M. B., Hughes, D. T., Zhu, C., Boedeker, E. C., & Sperandio, V. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0604343103 · Cited by 621 · see citing works
Self-citationHalogenated furanones inhibit quorum sensing through accelerated LuxR turnover
Manefield, M. J., Rasmussen, T. B., Henzter, M., Andersen, J. B., Steinberg, P. D., Kjelleberg, S. J., & Givskov, M. (2002) · Microbiology · doi:10.1099/00221287-148-4-1119 · Cited by 598 · see citing works
Pseudomonas aeruginosa Anaerobic Respiration in Biofilms
Yoon, S. S., Hennigan, R. F., Hilliard, G. M., Ochsner, U. A., Parvatiyar, K., Kamani, M. C., Allen, H. L., Dekievit, T., Gardner, P. R., Schwab, U. E., et al. (2002) · Developmental Cell · doi:10.1016/s1534-5807(02)00295-2 · Cited by 587 · see citing works
Lamont, I. L., Beare, P. A., Ochsner, U., Vasil, A. I., & Vasil, M. L. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.092016999 · Cited by 584 · see citing works
Recognition of Antimicrobial Peptides by a Bacterial Sensor Kinase
Bader, M. W., Sanowar, S., Daley, M. E., Schneider, A. R., Cho, U., Xu, W., Klevit, R. E., Moual, H. L., & Miller, S. I. (2005) · Cell · doi:10.1016/j.cell.2005.05.030 · Cited by 554 · see citing works
Extensive and specific responses of a eukaryote to bacterial quorum-sensing signals
Mathesius, U., Mulders, S., Gao, M., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.262672599 · Cited by 535 · see citing works
Bottomley, M. J., Muraglia, E., Bazzo, R., et al. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m700556200 · Cited by 461 · see citing works
Structure−Reactivity Studies of Serum Paraoxonase PON1 Suggest that Its Native Activity Is Lactonase
Khersonsky, O., & Tawfik, D. S. (2005) · Biochemistry · doi:10.1021/bi047440d · Cited by 459 · see citing works
Structure of a bacterial quorum-sensing transcription factor complexed with pheromone and DNA
Zhang, R., Pappas, K. M., Brace, J. L., et al. (2002) · Nature · doi:10.1038/nature00833 · Cited by 447 · see citing works
DiMango, E., Zar, H. J., Bryan, R. A., et al. (1995) · Journal of Clinical Investigation · doi:10.1172/jci118275 · Cited by 435 · see citing works
Quorum sensing: the many languages of bacteria
Reading, N. C., & Sperandio, V. (2005) · FEMS Microbiology Letters · doi:10.1111/j.1574-6968.2005.00001.x · Cited by 434 · see citing works
Self-citationNPAS2: A Gas-Responsive Transcription Factor
Dioum, E. M., Rutter, J. P., Tuckerman, J. R., Gonzalez, G., Gilles‐Gonzalez, M., & McKnight, S. L. (2002) · Science · doi:10.1126/science.1078456 · Cited by 432 · see citing works
Telford, G., Wheeler, D., Williams, P. M., et al. (1998) · Infection and Immunity · doi:10.1128/iai.66.1.36-42.1998 · Cited by 425 · see citing works
Quorum Sensing Is a Global Regulatory Mechanism in Enterohemorrhagic Escherichia coli O157:H7
Sperandio, V., Torres, A. G., Girón, J. A., et al. (2001) · Journal of Bacteriology · doi:10.1128/jb.183.17.5187-5197.2001 · Cited by 416 · see citing works
Self-citationCatecholamine induced growth of gram negative bacteria
Lyte, M., & Ernst, S. (1992) · Life Sciences · doi:10.1016/0024-3205(92)90273-r · Cited by 396 · see citing works
The crystal structure of the quorum sensing protein TraR bound to its autoinducer and target DNA
Vannini, A., Volpari, C., Gargioli, C., et al. (2002) · The EMBO Journal · doi:10.1093/emboj/cdf459 · Cited by 356 · see citing works
Smith, R. S., Harris, S. G., Phipps, R. P., et al. (2002) · Journal of Bacteriology · doi:10.1128/jb.184.4.1132-1139.2002 · Cited by 352 · see citing works
Tateda, K., Ishii, Y., Horikawa, M., Matsumoto, T., Miyairi, S., Pechère, J. C., Standiford, T. J., Ishiguro, M., & Yamaguchi, K. (2003) · Infection and Immunity · doi:10.1128/iai.71.10.5785-5793.2003 · Cited by 347 · see citing works
Pineal Serotonin N -Acetyltransferase: Expression Cloning and Molecular Analysis
Coon, S. L., Roseboom, P. H., Baler, R., et al. (1995) · Science · doi:10.1126/science.270.5242.1681 · Cited by 344 · see citing works
Structure of the GAF domain, a ubiquitous signaling motif and a new class of cyclic GMP receptor
Ho, Y. S. J., Burden, L. M., & Hurley, J. H. (2000) · The EMBO Journal · doi:10.1093/emboj/19.20.5288 · Cited by 333 · see citing works
Recognition of Host Immune Activation by Pseudomonas aeruginosa
Wu, L., Estrada, O., Zaborina, O. Y., Bains, M., Shen, L., Kohler, J. E., Patel, N. J., Musch, M. W., Chang, E. B., Fu, Y., et al. (2005) · Science · doi:10.1126/science.1112422 · Cited by 330 · see citing works
Multiple positive and negative regulators of signaling by the EGF-receptor
Moghal, N., & Sternberg, P. W. (1999) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(99)80025-8 · Cited by 326 · see citing works
In vivo negative selection screen identifies genes required for Francisella virulence
Weiss, D. S., Brotcke, A., Henry, T., Margolis, J. J., Chan, K., & Monack, D. M. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0609675104 · Cited by 317 · see citing works
Inactivation of a Pseudomonas aeruginosa quorum-sensing signal by human airway epithelia
Chun, C. K., Ozer, E. A., Welsh, M. J., Zabner, J., & Greenberg, E. P. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0308750101 · Cited by 287 · see citing works
Igo, M. M., Ninfa, A. J., Stock, J. B., & Silhavy, T. J. (1989) · Genes & Development · doi:10.1101/gad.3.11.1725 · Cited by 277 · see citing works
Smith, R. S., Fedyk, E. R., Springer, T. A., Mukaida, N., Iglewski, B. H., & Phipps, R. P. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.167.1.366 · Cited by 274 · see citing works
Plant responses to bacterial quorum sensing signals
Bauer, W., & Mathesius, U. (2004) · Current Opinion in Plant Biology · doi:10.1016/j.pbi.2004.05.008 · Cited by 263 · see citing works
GABA controls the level of quorum-sensing signal in Agrobacterium tumefaciens
Chevrot, R., Rosen, R., Haudecoeur, E., Beury-Cirou, A., Shelp, B. J., Ron, E. Z., & Faure, D. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0600313103 · Cited by 259 · see citing works
Targeting of an enteropathogenic Escherichia coli (EPEC) effector protein to host mitochondria
Kenny, B., & Jepson, M. A. (2000) · Cellular Microbiology · doi:10.1046/j.1462-5822.2000.00082.x · Cited by 257 · see citing works
Chhabra, S. R., Harty, C., Hooi, D. S. W., Daykin, M., Williams, P. M., Telford, G., Pritchard, D., & Bycroft, B. W. (2002) · Journal of Medicinal Chemistry · doi:10.1021/jm020909n · Cited by 247 · see citing works
Human and murine paraoxonase 1 are host modulators of Pseudomonas aeruginosa quorum-sensing
Ozer, E. A., Pezzulo, A. A., Shih, D. M., et al. (2005) · FEMS Microbiology Letters · doi:10.1016/j.femsle.2005.09.023 · Cited by 226 · see citing works
Persson, T., Hansen, T. H., Rasmussen, T. B., et al. (2004) · Organic & Biomolecular Chemistry · doi:10.1039/b415761c · Cited by 225 · see citing works
Interkingdom signaling: Deciphering the language of acyl homoserine lactones
Shiner, E. K., Rumbaugh, K. P., & Williams, S. C. (2005) · FEMS Microbiology Reviews · doi:10.1016/j.femsre.2005.03.001 · Cited by 222 · see citing works
Iyer, L. M., Aravind, L., Coon, S. L., Klein, D. C., & Koonin, E. V. (2004) · Trends in Genetics · doi:10.1016/j.tig.2004.05.007 · Cited by 219 · see citing works
The ins and outs of signalling
Downward, J. (2001) · Nature · doi:10.1038/35081138 · Cited by 212 · see citing works
Bearson, B. L., & Bearson, S. M. D. (2007) · Microbial Pathogenesis · doi:10.1016/j.micpath.2007.10.001 · Cited by 210 · see citing works
Freestone, P. P. E., Lyte, M., Neal, C. P., Maggs, A. F., Haigh, R., & WILLIAMS, P. H. (2000) · Journal of Bacteriology · doi:10.1128/jb.182.21.6091-6098.2000 · Cited by 210 · see citing works
Quorum quenching enzyme activity is widely conserved in the sera of mammalian species
Yang, F., Wang, L., Wang, J., et al. (2005) · FEBS Letters · doi:10.1016/j.febslet.2005.05.060 · Cited by 207 · see citing works
Alverdy, J., Holbrook, C., Rocha, F., Seiden, L., Licheng, R., Wu, Musch, M., Chang, E., Ohman, D., & Suh, S. (2000) · Annals of Surgery · doi:10.1097/00000658-200010000-00003 · Cited by 207 · see citing works
Dynorphin activates quorum sensing quinolone signaling in Pseudomonas aeruginosa
Zaborina, O., Lepine, F., Xiao, G., Valuckaite, V., Chen, Y., Li, T., Ciancio, M., Zaborin, A., Petroff, E., Turner, J. R., et al. (2007) · PLoS Pathogens · doi:10.1371/journal.ppat.0030035 · Cited by 207 · see citing works
ESCHERICHIA COLI CYTOTOXIN, HAEMOLYTIC-URAEMIC SYNDROME, AND HAEMORRHAGIC COLITIS
Karmali, M. A., Petrić, M., Lim, C., Fleming, P. C., & Steele, B. T. (1983) · The Lancet · doi:10.1016/s0140-6736(83)91167-4 · Cited by 202 · see citing works
AI-3 Synthesis Is Not Dependent onluxSinEscherichia coli
Walters, M. S., Sircili, M. P., & Sperandio, V. (2006) · Journal of Bacteriology · doi:10.1128/jb.00648-06 · Cited by 193 · see citing works
Self-citationYao, Y., Martinez‐Yamout, M. A., Dickerson, T. J., Brogan, A. P., Wright, P. E., & Dyson, H. J. (2005) · Journal of Molecular Biology · doi:10.1016/j.jmb.2005.10.041 · Cited by 180 · see citing works
The Pathogenesis of Hemorrhagic Colitis Caused by Escherichia coli O157:H7 in Gnotobiotic Piglets
Tzipori, S., Wachsmuth, I. K., Chapman, C., et al. (1986) · The Journal of Infectious Diseases · doi:10.1093/infdis/154.4.712 · Cited by 178 · see citing works
Elliott, S. J., Krejany, E. O., Mellies, J. L., Robins-Browne, R. M., Sasakawa, C., & Kaper, J. B. (2001) · Infection and Immunity · doi:10.1128/iai.69.6.4027-4033.2001 · Cited by 168 · see citing works
Tu, X., Nisan, I., Chen, Y., Hanski, E., & Rosenshine, I. (2003) · Molecular Microbiology · doi:10.1046/j.1365-2958.2003.03329.x · Cited by 165 · see citing works
Stevenson, L. G., Střı́šovský, K., Clemmer, K. M., Bhatt, S., Freeman, M., & Rather, P. N. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0608140104 · Cited by 163 · see citing works
The bacterial injection kit: Type III secretion systems
Mota, L. J., & Cornelis, G. R. (2005) · Annals of Medicine · doi:10.1080/07853890510037329 · Cited by 163 · see citing works
Pseudomonas aeruginosa autoinducer modulates host cell responses through calcium signalling
Shiner, E. K., Terentyev, D. A., Bryan, A., Sennoune, S. R., Martı́nez–Zaguilán, R., Li, G., Györke, S., Williams, S. C., & Rumbaugh, K. P. (2006) · Cellular Microbiology · doi:10.1111/j.1462-5822.2006.00734.x · Cited by 159 · see citing works
Walters, M., & Sperandio, V. (2006) · Infection and Immunity · doi:10.1128/iai.00099-06 · Cited by 158 · see citing works
Self-citationKnutton, S., Baldini, M. M., Kaper, J. B., et al. (1987) · Infection and Immunity · doi:10.1128/iai.55.1.78-85.1987 · Cited by 157 · see citing works
Transcriptional regulation of flhDC by QseBC and σ 28 (FliA) in enterohaemorrhagic Escherichia coli
Clarke, M. B., & Sperandio, V. (2005) · Molecular Microbiology · doi:10.1111/j.1365-2958.2005.04792.x · Cited by 156 · see citing works
Self-citationSmith, R. S., KELLY, R. W., Iglewski, B. H., & Phipps, R. P. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.5.2636 · Cited by 154 · see citing works
McNamara, B. P., & Donnenberg, M. S. (1998) · FEMS Microbiology Letters · doi:10.1111/j.1574-6968.1998.tb13185.x · Cited by 146 · see citing works
Paraoxonase-2 deficiency enhancesPseudomonas aeruginosaquorum sensing in murine tracheal epithelia
Stoltz, D. A., Ozer, E. A., Ng, C. J., et al. (2006) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00370.2006 · Cited by 144 · see citing works
Lyte, M., Arulanandam, B. P., & Frank, C. D. (1996) · Journal of Laboratory and Clinical Medicine · doi:10.1016/s0022-2143(96)80011-4 · Cited by 142 · see citing works
Reading, N. C., Torres, A. G., Kendall, M. M., Hughes, D. T., Yamamoto, K., & Sperandio, V. (2007) · Journal of Bacteriology · doi:10.1128/jb.01848-06 · Cited by 140 · see citing works
Self-citationLi, L., Hooi, D. S. W., Chhabra, S. R., Pritchard, D., & Shaw, P. E. (2004) · Oncogene · doi:10.1038/sj.onc.1207612 · Cited by 137 · see citing works
l -Canavanine Made byMedicago sativaInterferes with Quorum Sensing inSinorhizobium meliloti
Keshavan, N. D., Chowdhary, P. K., Haines, D. C., et al. (2005) · Journal of Bacteriology · doi:10.1128/jb.187.24.8427-8436.2005 · Cited by 137 · see citing works
Chemical Signaling among Bacteria and Its Inhibition
Lyon, G. J., & Muir, T. W. (2003) · Chemistry & Biology · doi:10.1016/j.chembiol.2003.11.003 · Cited by 132 · see citing works
Kendall, M. M., Rasko, D. A., & Sperandio, V. (2007) · Infection and Immunity · doi:10.1128/iai.00550-07 · Cited by 126 · see citing works
Self-citationFreddolino, L., Kalani, M. Y. S., Vaidehi, N., Floriano, W. B., Hall, S. E., Trabanino, R. J., Kam, V. W. T., & Goddard, W. A. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0308751101 · Cited by 124 · see citing works
Vlisidou, I., Lyte, M., van Diemen, P. M., Hawes, P. C., Monaghan, P., Wallis, T. S., & Stevens, M. P. (2004) · Infection and Immunity · doi:10.1128/iai.72.9.5446-5451.2004 · Cited by 117 · see citing works
Norepinephrine-Induced Expression of the K99 Pilus Adhesin of EnterotoxigenicEscherichia coli
Lyte, M., Erickson, A. K., Arulanandam, B. P., Frank, C. D., Crawford, M., & Francis, D. H. (1997) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1997.6356 · Cited by 114 · see citing works
Zimmermann, S., Wagner, C., Müller, W., et al. (2006) · Infection and Immunity · doi:10.1128/iai.01940-05 · Cited by 114 · see citing works
A conserved mechanism for extracellular signaling in eukaryotes and prokaryotes
Gallio, M., Sturgill, G. M., Rather, P. N., et al. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.192138799 · Cited by 113 · see citing works
Freestone, P. P. E., Haigh, R., WILLIAMS, P. H., & Lyte, M. (2003) · FEMS Microbiology Letters · doi:10.1016/s0378-1097(03)00243-x · Cited by 112 · see citing works
Burton, C. L., Chhabra, S. R., Swift, S., Baldwin, T. J., Withers, H. L., Hill, S. J., & Williams, P. M. (2002) · Infection and Immunity · doi:10.1128/iai.70.11.5913-5923.2002 · Cited by 111 · see citing works
Roychoudhury, S., Zielinski, N. A., Ninfa, A. J., et al. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.3.965 · Cited by 107 · see citing works
Ecological Behavior ofLactobacillus reuteri100-23 Is Affected by Mutation of theluxSGene
Tannock, G. W., Ghazally, S., Walter, J., Loach, D. M., Brooks, H. J. L., Cook, G. M., Surette, M. G., Simmers, C., Bremer, P. J., Bello, F. D., et al. (2005) · Applied and Environmental Microbiology · doi:10.1128/aem.71.12.8419-8425.2005 · Cited by 107 · see citing works
Ritchie, A. J., Yam, A. O. W., Tanabe, K. M., et al. (2003) · Infection and Immunity · doi:10.1128/iai.71.8.4421-4431.2003 · Cited by 106 · see citing works
Ritchie, A. J., Jansson, A., Stallberg, J., et al. (2005) · Infection and Immunity · doi:10.1128/iai.73.3.1648-1655.2005 · Cited by 96 · see citing works
Norepinephrine as a growth stimulating factor in bacteria—mechanistic studies
Kinney, K. S., Austin, C. E., Morton, D. S., & Sonnenfeld, G. (2000) · Life Sciences · doi:10.1016/s0024-3205(00)00891-2 · Cited by 95 · see citing works
Pseudomonas aeruginosa Autoinducer Enters and Functions in Mammalian Cells
Williams, S. C., Patterson, E. K., Carty, N. L., Griswold, J., Hamood, A. N., & Rumbaugh, K. P. (2004) · Journal of Bacteriology · doi:10.1128/jb.186.8.2281-2287.2004 · Cited by 86 · see citing works
Clarke, M. B., & Sperandio, V. (2005) · Molecular Microbiology · doi:10.1111/j.1365-2958.2005.04819.x · Cited by 85 · see citing works
Self-citationClonidine Reduces Diarrhea and Sodium Loss in Patients With Proximal Jejunostomy: A Controlled Study
Buchman, A. L., Fryer, J., Wallin, A., Ahn, C. W., Polensky, S., & Zaremba, K. (2006) · Journal of Parenteral and Enteral Nutrition · doi:10.1177/0148607106030006487 · Cited by 82 · see citing works
Kanack, K. J., Crawford, J. A., Tatsuno, I., Karmali, M. A., & Kaper, J. B. (2005) · Infection and Immunity · doi:10.1128/iai.73.7.4327-4337.2005 · Cited by 74 · see citing works
Nakano, M., Takahashi, A., Sakai, Y., & Nakaya, Y. (2007) · The Journal of Infectious Diseases · doi:10.1086/513275 · Cited by 74 · see citing works
Social stress increases fecal shedding of Salmonella typhimurium by early weaned piglets.
Callaway, T. R., Morrow, J. L., Edrington, T. S., Genovese, K. J., Dowd, S. E., Carroll, J. A., Dailey, J. W., Harvey, R. B., Poole, T. L., Anderson, R. C., et al. (2006) · PubMed · Cited by 70 · see citing works
Segment-specific effects of epinephrine on ion transport in the colon of the rat
Hörger, S., Schultheiß, G., & Diener, M. (1998) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1998.275.6.g1367 · Cited by 68 · see citing works
Rather, P. N., Ding, X., Baca-DeLancey, R. R., & Siddiqui, S. (1999) · Journal of Bacteriology · doi:10.1128/jb.181.23.7185-7191.1999 · Cited by 67 · see citing works
Convergence of hormones and autoinducers at the host/pathogen interface
Rumbaugh, K. P. (2006) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-006-0694-9 · Cited by 58 · see citing works
Characterization and distribution of alpha 2-adrenergic receptors in the human intestinal mucosa.
Valet, P., Senard, J. M., Devedjian, J. C., Planat, V, Salomon, R., Voisin, T., Drean, G., Couvineau, A., Daviaud, D., & Denis, C. (1993) · Journal of Clinical Investigation · doi:10.1172/jci116427 · Cited by 58 · see citing works
Kaper, J. B. (1998) · Japanese Journal of Medical Science and Biology · doi:10.7883/yoken1952.51.supplement1_s101 · Cited by 58 · see citing works
Rémaury, A., Larrouy, D., Daviaud, D., et al. (1993) · Biochemical Journal · doi:10.1042/bj2920283 · Cited by 57 · see citing works
The role of catecholamines in Gram-negative sepsis
Lyte, M. (1992) · Medical Hypotheses · doi:10.1016/0306-9877(92)90197-k · Cited by 54 · see citing works
Scheckelhoff, M., Telford, S. R., Wesley, M., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0607263104 · Cited by 47 · see citing works
Merighi, M., Carroll‐Portillo, A., Septer, A. N., Bhatiya, A., & Gunn, J. S. (2005) · Journal of Bacteriology · doi:10.1128/jb.188.1.141-149.2006 · Cited by 41 · see citing works
Horikawa, M., Tateda, K., Tuzuki, E., et al. (2006) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2006.01.054 · Cited by 40 · see citing works
DOPA, dopamine, and DOPAC concentrations in the rat gastrointestinal tract decrease during fasting
Eldrup, E., & Richter, E. A. (2000) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2000.279.4.e815 · Cited by 40 · see citing works
Rather, P. N., Parojcic, M. M., & Paradise, M. R. (1997) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.41.8.1749 · Cited by 34 · see citing works
PRITCHARD, D. I., Todd, I., Brown, A., et al. (2005) · Acta Diabetologica · doi:10.1007/s00592-005-0190-2 · Cited by 28 · see citing works
Flagged first, then by citations
Research works printed but not linked: 4
- [6]Molina PE. Endocrine Physiology. New York: The McGraw Hill Companies; 2006. [Google Scholar]
- [28]Purves D, et al. Neuroscience. New York: Sinauer Associates; 2001. [Google Scholar]
- [35]Kaper JB, O’Brien AD. Washington DC: ASM; 1998. Escherichia coli O157:H7 and other Shiga toxin-producing E. coli strains. [Google Scholar]
- [103]Lugtenberg B, Tikhonovich I, Provorov N, editors. Biology of Molecular Plant–Microbe Interactions. Vol. 4. Minnesota: IS-MPMI; 2004. [Google Scholar]
Cited by
Sorted by citations
Structure and functions of the bacterial microbiota of plants
Bulgarelli, D., Schlaeppi, K., Spaepen, S., van Themaat, E. V. L., & Schulze-Lefert, P. (2013) · Annual Review of Plant Biology · doi:10.1146/annurev-arplant-050312-120106 · Cited by 3,308 · see citing works
Gut feelings: the emerging biology of gut-brain communication
Mayer, E. A. (2011) · Nature Reviews Neuroscience · doi:10.1038/nrn3071 · Cited by 1,726 · see citing works
Gut/brain axis and the microbiota
Mayer, E. A., Tillisch, K., & Gupta, A. (2015) · Journal of Clinical Investigation · doi:10.1172/jci76304 · Cited by 1,503 · see citing works
Principles and clinical implications of the brain-gut-enteric microbiota axis
Rhee, S. H., Pothoulakis, C., & Mayer, E. A. (2009) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2009.35 · Cited by 1,342 · see citing works
“Both norepinephrine and dynorphins are thought to be released into the gut lumen during perturbation of homeostasis”
Martin, C. R., Osadchiy, V., Kalani, A., & Mayer, E. A. (2018) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2018.04.003 · Cited by 1,284 · see citing works
Indole as an intercellular signal in microbial communities
Lee, J.-H., & Lee, J. (2010) · FEMS Microbiology Reviews · doi:10.1111/j.1574-6976.2009.00204.x · Cited by 1,059 · see citing works
Genes and Molecules of Lactobacilli Supporting Probiotic Action
Lebeer, S., Vanderleyden, J., & De Keersmaecker, S. C. J. (2008) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00017-08 · Cited by 1,013 · see citing works
Asano, Y., Hiramoto, T., Nishino, R., Aiba, Y., Kimura, T., Yoshihara, K., Koga, Y., & Sudo, N. (2012) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00341.2012 · Cited by 659 · see citing works
Roles of indole as an interspecies and interkingdom signaling molecule
Lee, J.-H., Wood, T. K., & Lee, J. (2015) · Trends in Microbiology · doi:10.1016/j.tim.2015.08.001 · Cited by 516 · see citing works
Brain gut microbiome interactions and functional bowel disorders
Mayer, E. A., Savidge, T., & Shulman, R. J. (2014) · Gastroenterology · doi:10.1053/j.gastro.2014.02.037 · Cited by 496 · see citing works
Gut Bacteria and Neurotransmitters
Dicks, L. M. T. (2022) · Microorganisms · doi:10.3390/microorganisms10091838 · Cited by 482 · see citing works
Forsythe, P., Sudo, N., Dinan, T., Taylor, V. H., & Bienenstock, J. (2010) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2009.05.058 · Cited by 429 · see citing works
Commensal bacteria-dependent indole production enhances epithelial barrier function in the colon
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Dickson, R. P., Erb-Downward, J. R., & Huffnagle, G. B. (2014) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(14)70028-1 · Cited by 371 · see citing works
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Alegado, R. A., Brown, L. W., Cao, S., Dermenjian, R. K., Zuzow, R., Fairclough, S. R., Clardy, J., & King, N. (2012) · eLife · doi:10.7554/elife.00013 · Cited by 249 · see citing works
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Moreira, C. G., Weinshenker, D., & Sperandio, V. (2010) · Infection and Immunity · doi:10.1128/iai.01038-09 · Cited by 195 · see citing works
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“Specifically, in the GI tract, which is one of the most prominent sites in the human body where host/microbe associations are paramount, these neurotransmitters play important functions in gut homeostasis and physiology (19, 20, 71).”
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Daisley, B. A., Chanyi, R. M., Abdur-Rashid, K., Al, K. F., Gibbons, S., Chmiel, J. A., Wilcox, H., Reid, G., Anderson, A., Dewar, M., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-18649-5 · Cited by 128 · see citing works
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Hall, R. A., De Sordi, L., MacCallum, D. M., Topal, H., Eaton, R., Bloor, J. W., Robinson, G. K., Levin, L. R., Buck, J., Wang, Y., et al. (2010) · PLoS Pathogens · doi:10.1371/journal.ppat.1001193 · Cited by 126 · see citing works
Lam, Y., Maguire, S., Palacios, T., & Caterson, I. (2017) · Nutrients · doi:10.3390/nu9060602 · Cited by 86 · see citing works
Jan, C., Petersen, J. M., Werner, J., Teeling, H., Huang, S., Glöckner, F. O., Golyshina, O. V., Dubilier, N., Golyshin, P. N., Jebbar, M., et al. (2014) · Environmental Microbiology · doi:10.1111/1462-2920.12406 · Cited by 83 · see citing works
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Srivastava, R. K., Lutz, B., & Ruiz de Azua, I. (2022) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2022.867267 · Cited by 56 · see citing works
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Mani, S., Boelsterli, U. A., & Redinbo, M. R. (2014) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-011613-140007 · Cited by 48 · see citing works
Lyte, M., Villageliú, D. N., Crooker, B. A., & Brown, D. R. (2018) · Journal of Dairy Science · doi:10.3168/jds.2017-13589 · Cited by 38 · see citing works
Le Bloa, S., Durand, L., Cueff- Gauchard, V., Le Bars, J., Taupin, L., Marteau, C., Bazire, A., & Cambon-Bonavita, M.-A. (2017) · PLoS ONE · doi:10.1371/journal.pone.0174338 · Cited by 12 · see citing works
- Authors
- Hughes, D. T., & Sperandio, V.
- Affiliations
- The University of Texas Southwestern Medical Center (US)
- Corresponding author
- Sperandio, Vanessa
- Venue
- Nature Reviews Microbiology
- Published
- 2008-02
- Volume
- 6
- Issue
- 2
- Pages
- 111-120
- ISSN
- 1740-1526 (ISSN-L)
- 1740-1534
- PMC
- PMC2667375
- OpenAlex
- W2125448515
- Cited by
- 761
- References
- 107
- Citations by year
- 2026: 29 · 2025: 35 · 2024: 35 · 2023: 40 · 2022: 55 · 2021: 59 · 2020: 44 · 2019: 39 · 2018: 45 · 2017: 40 · 2016: 39 · 2015: 53 · 2014: 37 · 2013: 36 · 2012: 41
- FWCI
- 3.47
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Reviews Microbiology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Burroughs Wellcome Fund
- Ellison Medical Foundation
- National Institutes of Health
- National Institute of Allergy and Infectious Diseases (R01AI053067, U01AI077853, P01AI055637, R21AI054468)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bacterial biofilms and quorum sensing
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant-Microbe Interactions and Immunity
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Escherichia coli research studies
- Keywords
- quorum sensing, mutualistic relationships, microbial communities, cell-to-cell communication
- MeSH terms
- Bacteria, Eukaryotic Cells, Hormones, Plants, 4-Butyrolactone, Signal Transduction, Gene Expression Regulation, Bacterial, Acyl-Butyrolactones, Host-Pathogen Interactions
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