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Essential Roles for Ecdysone Signaling During Drosophila Mid-Embryonic Development
Abstract
Although functions for the steroid hormone ecdysone during Drosophila metamorphosis have been well established, roles for the embryonic ecdysone pulse remain poorly understood. We show that the EcR-USP ecdysone receptor is first activated in the extraembryonic amnioserosa, implicating this tissue as a source of active ecdysteroids in the early embryo. Ecdysone signaling is required for germ band retraction and head involution, morphogenetic movements that shape the first instar larva. This mechanism for coordinating morphogenesis during Drosophila embryonic development parallels the role of ecdysone during metamorphosis. It also provides an intriguing parallel with the role of mammalian extraembryonic tissues as a critical source of steroid hormones during embryonic development.
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Cited by
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King-Jones, K., & Thummel, C. S. (2005) · Nature Reviews Genetics · doi:10.1038/nrg1581 · Cited by 586
Self-citationRusten, T. E., Lindmo, K., Juhász, G., Sass, M., Seglen, P. O., Brech, A., & Stenmark, H. (2004) · Developmental Cell · doi:10.1016/j.devcel.2004.07.005 · Cited by 490
Regulation of ecdysone production in Drosophila by neuropeptides and peptide hormones
Kannangara, J. R., Mirth, C. K., & Warr, C. G. (2021) · Open Biology · doi:10.1098/rsob.200373 · Cited by 84
Sex and stripping: The key to the intimate relationship between Wolbachia and host?
Negri, I., Pellecchia, M., Grève, P., Daffonchio, D., Bandi, C., & Alma, A. (2010) · Communicative & Integrative Biology · doi:10.4161/cib.3.2.10520 · Cited by 18
Metadata
- Authors
- Kozlova, T., & Thummel, C. S.
- Venue
- Science
- Published
- 2003-09-26
- Volume
- 301
- Issue
- 5641
- Pages
- 1911-1914
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1978383473
- Cited by
- 179
- References
- 0
- FWCI
- 3.32
- Type
- journal article
- Language
- en
- Open access
- closed
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