Cited by 84Neurobiology and Insect Physiology ResearchNeuropeptides and Animal PhysiologyDevelopmental Biology and Gene Regulation

Regulation of ecdysone production in Drosophila by neuropeptides and peptide hormones

Open access
Kannangara, Jade R., Mirth, Christen K., Warr, Coral G.·2021·Open Biology

Abstract

In both mammals and insects, steroid hormones play a major role in directing the animal's progression through developmental stages. To maximize fitness outcomes, steroid hormone production is regulated by the environmental conditions experienced by the animal. In insects, the steroid hormone ecdysone mediates transitions between developmental stages and is regulated in response to environmental factors such as nutrition. These environmental signals are communicated to the ecdysone-producing gland via the action of neuropeptide and peptide hormone signalling pathways. While some of these pathways have been well characterized, there is evidence to suggest more signalling pathways than has previously been thought function to control ecdysone production, potentially in response to a greater range of environmental conditions. Here, we review the neuropeptide and peptide hormone signalling pathways known to regulate the production of ecdysone in the model genetic insect Drosophila melanogaster , as well as what is known regarding the environmental signals that trigger these pathways. Areas for future research are highlighted that can further contribute to our overall understanding of the complex orchestration of environmental, physiological and developmental cues that together produce a functioning adult organism.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1098/rsob.200373

Cites

117 of 117 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • 20E is produced from cholesterol through a multi-step process that is not yet fully elucidated.

    “20E is produced from cholesterol through a multi-step process that is not yet fully elucidated [7,11,12] (Figure 4).”

    From Ecdysteroids (2021) · cites this paper as [7]

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Kannangara, J. R., Mirth, C. K., & Warr, C. G.
Affiliations
  • Monash University (AU)
  • University of Tasmania (AU)
Corresponding author
Warr, Coral G.
Venue
Open Biology
Published
2021-02
Volume
11
Issue
2
Pages
200373-200373
ISSN
2046-2441 (ISSN-L)
OpenAlex
W3129821944
Cited by
84
References
117
Citations by year
2026: 18 · 2025: 21 · 2024: 13 · 2023: 15 · 2022: 8 · 2021: 9
FWCI
1.70
Type
journal article
Language
en
Open access
Locations
  • Open Biology (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • UTAS Research Repository (acceptedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • Figshare (submittedVersion, cc-by)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Keywords
neuropeptides, peptide hormones, Drosophila melanogaster, steroid hormone regulation, developmental transitions, environmental cues, nutrition, insect development
MeSH terms
Animals, Drosophila melanogaster, Ecdysone, Neuropeptides, Gene Expression Regulation, Developmental, Drosophila Proteins

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review