Regulation of ecdysone production in Drosophila by neuropeptides and peptide hormones
Open accessAbstract
In both mammals and insects, steroid hormones play a major role in directing the animal's progression through developmental stages. To maximize fitness outcomes, steroid hormone production is regulated by the environmental conditions experienced by the animal. In insects, the steroid hormone ecdysone mediates transitions between developmental stages and is regulated in response to environmental factors such as nutrition. These environmental signals are communicated to the ecdysone-producing gland via the action of neuropeptide and peptide hormone signalling pathways. While some of these pathways have been well characterized, there is evidence to suggest more signalling pathways than has previously been thought function to control ecdysone production, potentially in response to a greater range of environmental conditions. Here, we review the neuropeptide and peptide hormone signalling pathways known to regulate the production of ecdysone in the model genetic insect Drosophila melanogaster , as well as what is known regarding the environmental signals that trigger these pathways. Areas for future research are highlighted that can further contribute to our overall understanding of the complex orchestration of environmental, physiological and developmental cues that together produce a functioning adult organism.
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20E is produced from cholesterol through a multi-step process that is not yet fully elucidated.
“20E is produced from cholesterol through a multi-step process that is not yet fully elucidated [7,11,12] (Figure 4).”
From Ecdysteroids (2021) · cites this paper as [7]
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Flagged first, then by citations
Cited by
Sorted by citations
Lafont, R., Balducci, C., & Dinan, L. (2021) · Encyclopedia · doi:10.3390/encyclopedia1040096 · Cited by 49 · see citing works
- Authors
- Kannangara, J. R., Mirth, C. K., & Warr, C. G.
- Affiliations
- Monash University (AU)
- University of Tasmania (AU)
- Corresponding author
- Warr, Coral G.
- Venue
- Open Biology
- Publisher
- The Royal Society
- Published
- 2021-02
- Volume
- 11
- Issue
- 2
- Pages
- 200373-200373
- ISSN
- 2046-2441 (ISSN-L)
- PMC
- PMC8103234
- OpenAlex
- W3129821944
- Cited by
- 84
- References
- 117
- Citations by year
- 2026: 18 · 2025: 21 · 2024: 13 · 2023: 15 · 2022: 8 · 2021: 9
- FWCI
- 1.70
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Open Biology (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- UTAS Research Repository (acceptedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Figshare (submittedVersion, cc-by)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Keywords
- neuropeptides, peptide hormones, Drosophila melanogaster, steroid hormone regulation, developmental transitions, environmental cues, nutrition, insect development
- MeSH terms
- Animals, Drosophila melanogaster, Ecdysone, Neuropeptides, Gene Expression Regulation, Developmental, Drosophila Proteins
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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