The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
How Enzymes Work: Analysis by Modern Rate Theory and Computer Simulations
Abstract
Advances in transition state theory and computer simulations are providing new insights into the sources of enzyme catalysis. Both lowering of the activation free energy and changes in the generalized transmission coefficient (recrossing of the transition state, tunneling, and nonequilibrium contributions) can play a role. A framework for understanding these effects is presented, and the contributions of the different factors, as illustrated by specific enzymes, are identified and quantified by computer simulations. The resulting understanding of enzyme catalysis is used to comment on alternative proposals of how enzymes work.
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Citations
Cites
Current Status of Transition-State Theory
Truhlar, D. G., Garrett, B. C., & Klippenstein, S. J. (1996) · The Journal of Physical Chemistry · doi:10.1021/jp953748q · Cited by 2,279
Self-citationTransition-state Ensemble in Enzyme Catalysis: Possibility, Reality, or Necessity?
MA, B., KUMAR, S., TSAI, C.-J., HU, Z., & NUSSINOV, R. (2000) · Journal of Theoretical Biology · doi:10.1006/jtbi.2000.1097 · Cited by 86
Cited by
Catalytically Active Nanomaterials: A Promising Candidate for Artificial Enzymes
Lin, Y., Ren, J., & Qu, X. (2014) · Accounts of Chemical Research · doi:10.1021/ar400250z · Cited by 1,252
The Moderately Efficient Enzyme: Evolutionary and Physicochemical Trends Shaping Enzyme Parameters
Bar-Even, A., Noor, E., Savir, Y., Liebermeister, W., Davidi, D., Tawfik, D. S., & Milo, R. (2011) · Biochemistry · doi:10.1021/bi2002289 · Cited by 1,050
Payne, C. M., Knott, B. C., Mayes, H. B., Hansson, H., Himmel, M. E., Sandgren, M., Ståhlberg, J., & Beckham, G. T. (2015) · Chemical Reviews · doi:10.1021/cr500351c · Cited by 855
Taking Ockham's razor to enzyme dynamics and catalysis
Glowacki, D. R., Harvey, J. N., & Mulholland, A. J. (2012) · Nature Chemistry · doi:10.1038/nchem.1244 · Cited by 232
Does quantum mechanics play a non-trivial role in life?
Davies, P. C. W. (2004) · Biosystems · doi:10.1016/j.biosystems.2004.07.001 · Cited by 187
Metadata
- Authors
- Garcia-Viloca, M., Gao, J., Karplus, M., & Truhlar, D. G.
- Venue
- Science
- Published
- 2004-01-09
- Volume
- 303
- Issue
- 5655
- Pages
- 186-195
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2096921126
- Cited by
- 1,171
- References
- 2
- FWCI
- 54.02
- Type
- journal article
- Language
- en
- Open access
- closed
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- Garcia-Viloca, M., Gao, J., Karplus, M., & Truhlar, D. G. (2004). How Enzymes Work: Analysis by Modern Rate Theory and Computer Simulations. Science. https://doi.org/10.1126/science.1088172
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
