The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.
Crystal Structure of Biotin Synthase, an S -Adenosylmethionine-Dependent Radical Enzyme
Open accessAbstract
The crystal structure of biotin synthase from Escherichia coli in complex with S- adenosyl- L -methionine and dethiobiotin has been determined to 3.4 angstrom resolution. This structure addresses how “AdoMet radical” or “radical SAM” enzymes use Fe 4 S 4 clusters and S- adenosyl- L -methionine to generate organic radicals. Biotin synthase catalyzes the radical-mediated insertion of sulfur into dethiobiotin to form biotin. The structure places the substrates between the Fe 4 S 4 cluster, essential for radical generation, and the Fe 2 S 2 cluster, postulated to be the source of sulfur, with both clusters in unprecedented coordination environments.
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The Structural and Biochemical Foundations of Thiamin Biosynthesis
Jurgenson, C. T., Begley, T. P., & Ealick, S. E. (2009) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.78.072407.102340 · Cited by 355
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Braakman, R., & Smith, E. (2012) · Physical Biology · doi:10.1088/1478-3975/10/1/011001 · Cited by 158
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Sirithanakorn, C., & Cronan, J. E. (2021) · FEMS Microbiology Reviews · doi:10.1093/femsre/fuab003 · Cited by 106
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Metadata
- Authors
- Berkovitch, F., Nicolet, Y., Wan, J. T., Jarrett, J. T., & Drennan, C. L.
- Venue
- Science
- Published
- 2004-01-02
- Volume
- 303
- Issue
- 5654
- Pages
- 76-79
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2164545938
- Cited by
- 423
- References
- 26
- FWCI
- 27.38
- Type
- journal article
- Language
- en
- Open access
- green
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- Berkovitch, F., Nicolet, Y., Wan, J. T., Jarrett, J. T., & Drennan, C. L. (2004). Crystal Structure of Biotin Synthase, an S -Adenosylmethionine-Dependent Radical Enzyme. Science. https://doi.org/10.1126/science.1088493
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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