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Genetic Regulation: The Lac Control Region: The nucleotide sequence of the lac control region containing the promoter and operator is presented.
Abstract
The nucleotide sequence of the lac promoter-operator region has been determined. The 122 base pairs comprising this region include the recognition sites for RNA polymerase, the positive regulatory protein, CAP, and the negative regulatory protein, the repressor. Identification of mutant variants of the sequence combined with the in vitro biochemical studies of others has allowed us to tentatively identify the recognition site for each of these proteins, and to suggest how CAP might act at a distance to affect the interaction of RNA polymerase with the promoter.
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Cited by
Yanisch-Perron, C., Vieira, J., & Messing, J. (1985) · Gene · doi:10.1016/0378-1119(85)90120-9 · Cited by 15,041
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Simons, R. W., Houman, F., & Kleckner, N. (1987) · Gene · doi:10.1016/0378-1119(87)90095-3 · Cited by 1,518
Linkage map of Escherichia coli K-12, edition 6
Bachmann, B., & Low, K. B. (1980) · Microbiological Reviews · doi:10.1128/mmbr.44.1.1-56.1980 · Cited by 938
Expression in Escherichia coli of a Chemically Synthesized Gene for the Hormone Somatostatin
Itakura, K., Hirose, T., Crea, R., Riggs, A. D., Heyneker, H. L., Bolivar, F., & Boyer, H. W. (1977) · Science · doi:10.1126/science.412251 · Cited by 853
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Hasty, J., Pradines, J., Dolnik, M., & Collins, J. J. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.040411297 · Cited by 607
Metadata
- Authors
- Dickson, R. C., Abelson, J., Barnes, W. M., & Reznikoff, W. S.
- Venue
- Science
- Published
- 1975-01-10
- Volume
- 187
- Issue
- 4171
- Pages
- 27-35
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2020586816
- Cited by
- 516
- References
- 0
- FWCI
- 49.52
- Type
- journal article
- Language
- en
- Open access
- closed
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- Dickson, R. C., Abelson, J., Barnes, W. M., & Reznikoff, W. S. (1975). Genetic Regulation: The Lac Control Region: The nucleotide sequence of the lac control region containing the promoter and operator is presented. Science. https://doi.org/10.1126/science.1088926
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