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One-Way Control of FWA Imprinting in Arabidopsis Endosperm by DNA Methylation
Abstract
The Arabidopsis FWA gene was initially identified from late-flowering epigenetic mutants that show ectopic FWA expression associated with heritable hypomethylation of repeats around transcription starting sites. Here, we show that wild-type FWA displays imprinted (maternal origin–specific) expression in endosperm. The FWA imprint depends on the maintenance DNA methyltransferase MET1, as is the case in mammals. Unlike mammals, however, the FWA imprint is not established by allele-specific de novo methylation. It is established by maternal gametophyte–specific gene activation, which depends on a DNA glycosylase gene, DEMETER . Because endosperm does not contribute to the next generation, the activated FWA gene need not be silenced again. Double fertilization enables plants to use such “one-way” control of imprinting and DNA methylation in endosperm.
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Citations
Cited by
Transposable elements and the epigenetic regulation of the genome
Slotkin, R. K., & Martienssen, R. (2007) · Nature Reviews Genetics · doi:10.1038/nrg2072 · Cited by 2,044
Manning, K., Tör, M., Poole, M., Hong, Y., Thompson, A. J., King, G. J., Giovannoni, J. J., & Seymour, G. B. (2006) · Nature Genetics · doi:10.1038/ng1841 · Cited by 1,310
Role of transposable elements in heterochromatin and epigenetic control
Lippman, Z., Gendrel, A.-V., Black, M., Vaughn, M. W., Dedhia, N., Richard McCombie, W., Lavine, K., Mittal, V., May, B., Kasschau, K. D., et al. (2004) · Nature · doi:10.1038/nature02651 · Cited by 1,065
Gardening the genome: DNA methylation in Arabidopsis thaliana
Chan, S. W.-L., Henderson, I. R., & Jacobsen, S. E. (2005) · Nature Reviews Genetics · doi:10.1038/nrg1601 · Cited by 891
Self-citationEpigenetic inheritance in plants
Henderson, I. R., & Jacobsen, S. E. (2007) · Nature · doi:10.1038/nature05917 · Cited by 835
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Metadata
- Authors
- Kinoshita, T., Miura, A., Choi, Y., Kinoshita, Y., Cao, X., Jacobsen, S. E., Fischer, R. L., & Kakutani, T.
- Venue
- Science
- Published
- 2004-01-23
- Volume
- 303
- Issue
- 5657
- Pages
- 521-523
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2091601313
- Cited by
- 551
- References
- 0
- FWCI
- 13.90
- Type
- journal article
- Language
- en
- Open access
- closed
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- Kinoshita, T., Miura, A., Choi, Y., Kinoshita, Y., Cao, X., Jacobsen, S. E., Fischer, R. L., & Kakutani, T. (2004). One-Way Control of FWA Imprinting in Arabidopsis Endosperm by DNA Methylation. Science. https://doi.org/10.1126/science.1089835
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