The DOI matches its Crossref record.
Structural Basis of Transcription: Separation of RNA from DNA by RNA Polymerase II
Abstract
The structure of an RNA polymerase II–transcribing complex has been determined in the posttranslocation state, with a vacancy at the growing end of the RNA-DNA hybrid helix. At the opposite end of the hybrid helix, the RNA separates from the template DNA. This separation of nucleic acid strands is brought about by interaction with a set of proteins loops in a strand/loop network. Formation of the network must occur in the transition from abortive initiation to promoter escape.
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Citations
Cited by
Duquette, M. L., Handa, P., Vincent, J. A., Taylor, A. F., & Maizels, N. (2004) · Genes & Development · doi:10.1101/gad.1200804 · Cited by 553
Complete RNA Polymerase II Elongation Complex Structure and Its Interactions with NTP and TFIIS
Kettenberger, H., Armache, K.-J., & Cramer, P. (2004) · Molecular Cell · doi:10.1016/j.molcel.2004.11.040 · Cited by 437
DksA potentiates direct activation of amino acid promoters by ppGpp
Paul, B. J., Berkmen, M. B., & Gourse, R. L. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0501170102 · Cited by 326
Sequence-specific binding of single-stranded RNA: is there a code for recognition?
Auweter, S. D., Oberstrass, F. C., & Allain, F. H.-T. (2006) · Nucleic Acids Research · doi:10.1093/nar/gkl620 · Cited by 314
Structure of Eukaryotic RNA Polymerases
Cramer, P., Armache, K.-J., Baumli, S., Benkert, S., Brueckner, F., Buchen, C., Damsma, G. E., Dengl, S., Geiger, S. R., Jasiak, A. J., et al. (2008) · Annual Review of Biophysics · doi:10.1146/annurev.biophys.37.032807.130008 · Cited by 304
Metadata
- Authors
- Westover, K. D., Bushnell, D. A., & Kornberg, R. D.
- Venue
- Science
- Published
- 2004-02-13
- Volume
- 303
- Issue
- 5660
- Pages
- 1014-1016
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2044085514
- Cited by
- 256
- References
- 0
- FWCI
- 10.50
- Type
- journal article
- Language
- en
- Open access
- closed
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- Westover, K. D., Bushnell, D. A., & Kornberg, R. D. (2004). Structural Basis of Transcription: Separation of RNA from DNA by RNA Polymerase II. Science. https://doi.org/10.1126/science.1090839
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
