The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Intracellular transcription of G-rich DNAs induces formation of G-loops, novel structures containing G4 DNA
Open accessAbstract
We show that intracellular transcription of G-rich regions produces novel DNA structures, visible by electron microscopy as large (150–500 bp) loops. These G-loops are formed cotranscriptionally, and they contain G4 DNA on one strand and a stable RNA/DNA hybrid on the other. G-loop formation requires a G-rich nontemplate strand and reflects the unusual stability of the rG/dC base pair. G-loops and G4 DNA form efficiently within plasmid genomes transcribed in vitro or in Escherichia coli. These results establish that G4 DNA can form in vivo, a finding with implications for stability and maintenance of all G-rich genomic regions.
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Cites
Thermodynamic parameters to predict stability of RNA/DNA hybrid duplexes
Sugimoto, N., Nakano, S.-I., Katoh, M., Matsumura, A., Nakamuta, H., Ohmichi, T., Yoneyama, M., & Sasaki, M. (1995) · Biochemistry · doi:10.1021/bi00035a029 · Cited by 697 · cited 2×
“A hybrid of G-rich RNA and C-rich DNA would be predicted to be quite stable, reflecting the high stability of the rG/dC base pair and stacking of adjacent guanines in the RNA (Sugimoto et al. 1995).”
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Metadata
- Authors
- Duquette, M. L., Handa, P., Vincent, J. A., Taylor, A. F., & Maizels, N.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2004-07-01
- Volume
- 18
- Issue
- 13
- Pages
- 1618-1629
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W2100440853
- Cited by
- 553
- References
- 1
- Type
- posted content
- Language
- en
- Open access
- diamond
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- Duquette, M. L., Handa, P., Vincent, J. A., Taylor, A. F., & Maizels, N. (2004). Intracellular transcription of G-rich DNAs induces formation of G-loops, novel structures containing G4 DNA. Genes & Development. https://doi.org/10.1101/gad.1200804
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