The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.
Effects of Mosquito Genes on Plasmodium Development
Abstract
Malaria parasites must complete a complex developmental cycle in an Anopheles mosquito vector before transmission to a vertebrate host. Sexual development of the parasite in the midgut is initiated in the lumen immediately after the mosquito ingests infected blood, and the resulting ookinetes must traverse the surrounding epithelial layer before transforming into oocysts. The innate immune system of the mosquito is activated during midgut invasion, but to date, no evidence has been published identifying mosquito immune genes that affect parasite development. Here, we show by gene silencing that an Anopheles gambiae leucine rich-repeat protein acts as an antagonist and two C-type lectines act as protective agonists on the development of Plasmodium ookinetes to oocysts.
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Cites
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Self-citationThe leucine-rich repeat as a protein recognition motif
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Cited by
Implication of the Mosquito Midgut Microbiota in the Defense against Malaria Parasites
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Evolutionary Dynamics of Immune-Related Genes and Pathways in Disease-Vector Mosquitoes
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Self-citationHighly evolvable malaria vectors: The genomes of 16 Anopheles mosquitoes
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Self-citationInsect immunology and hematopoiesis
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Gene drive systems for insect disease vectors
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Metadata
- Authors
- Osta, M. A., Christophides, G. K., & Kafatos, F. C.
- Venue
- Science
- Published
- 2004-03-26
- Volume
- 303
- Issue
- 5666
- Pages
- 2030-2032
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2008716207
- Cited by
- 411
- References
- 18
- FWCI
- 39.26
- Type
- journal article
- Language
- en
- Open access
- closed
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
