Cited by 407Developmental Biology and Gene RegulationMarine Invertebrate Physiology and EcologyPlanarian Biology and Electrostimulation

The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.

Origins of Bilateral Symmetry: Hox and Dpp Expression in a Sea Anemone

Finnerty, John R., Pang, Kevin, Burton, Pat, Paulson, Dave, Martindale, Mark Q.·2004·Science

Abstract

Over 99% of modern animals are members of the evolutionary lineage Bilateria. The evolutionary success of Bilateria is credited partly to the origin of bilateral symmetry. Although animals of the phylum Cnidaria are not within the Bilateria, some representatives, such as the sea anemone Nematostella vectensis, exhibit bilateral symmetry. We show that Nematostella uses homologous genes to achieve bilateral symmetry: Multiple Hox genes are expressed in a staggered fashion along its primary body axis, and the transforming growth factor-beta gene decapentaplegic (dpp) is expressed in an asymmetric fashion about its secondary body axis. These data suggest that bilateral symmetry arose before the evolutionary split of Cnidaria and Bilateria.

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Crossref · 10.1126/science.1091946

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Research works printed but not linked: 7

  1. M. F. Glaessner, M. Wade, Palaeontology9, 599 (1966).
  2. 10.1017/S000632310000548X · DOI · Paper page
  3. J. R. Finnerty, Am. Zool.41, 608 (2001).
  4. E. Haeckel, Q. J. Microsc. Sci.14, 142 (1874).
  5. R. Siewing, Zool. Jahrb. Abt. Syst. Oekol. Geogr. Tiere103, 439 (1980).
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Metadata

Authors
Finnerty, J. R., Pang, K., Burton, P., Paulson, D., & Martindale, M. Q.
Affiliations
  • Boston University (US)
  • Department of Biology, Boston University, 5 Cummington Street, Boston, MA 02215, USA.
Corresponding author
Finnerty, John R.
Venue
Science
Published
2004-05-28
Volume
304
Issue
5675
Pages
1335-1337
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
OpenAlex
W2030545022
Cited by
407
References
28
Citations by year
2026: 6 · 2025: 8 · 2024: 14 · 2023: 6 · 2022: 16 · 2021: 11 · 2020: 6 · 2019: 16 · 2018: 12 · 2017: 11 · 2016: 14 · 2015: 24 · 2014: 18 · 2013: 10 · 2012: 16
FWCI
16.02
Type
journal article
Language
en
Open access
closed
Locations
  • Science (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
  • Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Marine Invertebrate Physiology and Ecology
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Planarian Biology and Electrostimulation
Keywords
bilateral symmetry, Nematostella vectensis, sea anemone, Hox genes, decapentaplegic, DPP, TGF-beta, body axis patterning, Cnidaria, homologous genes
MeSH terms
Amino Acid Sequence, Animals, Endoderm, Genes, Genes, Homeobox, Larva, Molecular Sequence Data, Phylogeny, Sea Anemones, In Situ Hybridization, Gene Expression Regulation, Developmental, Body Patterning, Gene Duplication, Gene Expression Profiling

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