The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.
The Ubiquitin Ligase SCF Fbw7 Antagonizes Apoptotic JNK Signaling
Abstract
Jun N-terminal kinases (JNKs) are essential for neuronal microtubule assembly and apoptosis. Phosphorylation of the activating protein 1 (AP1) transcription factor c-Jun, at multiple sites within its transactivation domain, is required for JNK-induced neurotoxicity. We report that in neurons the stability of c-Jun is regulated by the E3 ligase SCF Fbw7 , which ubiquitinates phosphorylated c-Jun and facilitates c-Jun degradation. Fbw7 depletion resulted in accumulation of phosphorylated c-Jun, stimulation of AP1 activity, and neuronal apoptosis. SCF Fbw7 therefore antagonizes the apoptotic c-Jun–dependent effector arm of JNK signaling, allowing neurons to tolerate potentially neurotoxic JNK activity.
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A System for Stable Expression of Short Interfering RNAs in Mammalian Cells
Brummelkamp, T. R., Bernards, R., & Agami, R. (2002) · Science · doi:10.1126/science.1068999 · Cited by 4,291
Signal transduction by the JNK group of MAP kinases
Davis, R. J. (2000) · Cell · doi:10.1016/s0092-8674(00)00116-1 · Cited by 4,237
AP-1 as a regulator of cell life and death
Shaulian, E., & Karin, M. (2002) · Nature Cell Biology · doi:10.1038/ncb0502-e131 · Cited by 2,961
Disruption of the glucocorticoid receptor gene in the nervous system results in reduced anxiety
Tronche, F., Kellendonk, C., Kretz, O., Gass, P., Anlag, K., Orban, P. C., Bock, R., Klein, R., & Schütz, G. (1999) · Nature Genetics · doi:10.1038/12703 · Cited by 1,838
SCF and Cullin/RING H2-Based Ubiquitin Ligases
Deshaies, R. J. (1999) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.15.1.435 · Cited by 1,242
Absence of excitotoxicity-induced apoptosis in the hippocampus of mice lacking the Jnk3 gene
Yang, D. D., Kuan, C.-Y., Whitmarsh, A. J., Rinócn, M., Zheng, T. S., Davis, R. J., Rakic, P., & Flavell, R. A. (1997) · Nature · doi:10.1038/39899 · Cited by 1,238
Cleavage of Cohesin by the CD Clan Protease Separin Triggers Anaphase in Yeast
Uhlmann, F., Wernic, D., Poupart, M.-A., Koonin, E. V., & Nasmyth, K. (2000) · Cell · doi:10.1016/s0092-8674(00)00130-6 · Cited by 798
Phosphorylation-Dependent Ubiquitination of Cyclin E by the SCF Fbw7 Ubiquitin Ligase
Koepp, D. M., Schaefer, L. K., Ye, X., Keyomarsi, K., Chu, C., Harper, J. W., & Elledge, S. J. (2001) · Science · doi:10.1126/science.1065203 · Cited by 762
Behrens, A., Sibilia, M., & Wagner, E. F. (1999) · Nature Genetics · doi:10.1038/6854 · Cited by 676
Self-citationStrohmaier, H., Spruck, C. H., Kaiser, P., Won, K.-A., Sangfelt, O., & Reed, S. I. (2001) · Nature · doi:10.1038/35095076 · Cited by 583
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Soucy, T. A., Smith, P. G., Milhollen, M. A., Berger, A. J., Gavin, J. M., Adhikari, S., Brownell, J. E., Burke, K. E., Cardin, D. P., Critchley, S., et al. (2009) · Nature · doi:10.1038/nature07884 · Cited by 1,990
Welcker, M., & Clurman, B. E. (2008) · Nature Reviews Cancer · doi:10.1038/nrc2290 · Cited by 1,084
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Mockaitis, K., & Estelle, M. (2008) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.23.090506.123214 · Cited by 651
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Metadata
- Authors
- Nateri, A. S., Riera-Sans, L., Costa, C. D., & Behrens, A.
- Venue
- Science
- Published
- 2004-02-27
- Volume
- 303
- Issue
- 5662
- Pages
- 1374-1378
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2138779676
- Cited by
- 339
- References
- 22
- FWCI
- 9.40
- Type
- journal article
- Language
- en
- Open access
- closed
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- Nateri, A. S., Riera-Sans, L., Costa, C. D., & Behrens, A. (2004). The Ubiquitin Ligase SCF Fbw7 Antagonizes Apoptotic JNK Signaling. Science. https://doi.org/10.1126/science.1092880
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
