Cited by 1,084Ubiquitin and proteasome pathwaysCancer-related Molecular PathwaysProtein Degradation and Inhibitors

FBW7 ubiquitin ligase: a tumour suppressor at the crossroads of cell division, growth and differentiation

Welcker, Markus, Clurman, Bruce E.·2008·Nature Reviews Cancer

Abstract

FBW7 (F-box and WD repeat domain-containing 7) is the substrate recognition component of an evolutionary conserved SCF (complex of SKP1, CUL1 and F-box protein)-type ubiquitin ligase. SCF(FBW7) degrades several proto-oncogenes that function in cellular growth and division pathways, including MYC, cyclin E, Notch and JUN. FBW7 is also a tumour suppressor, the regulatory network of which is perturbed in many human malignancies. Numerous cancer-associated mutations in FBW7 and its substrates have been identified, and loss of FBW7 function causes chromosomal instability and tumorigenesis. This Review focuses on structural and functional aspects of FBW7 and its role in the development of cancer.

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Crossref · 10.1038/nrc2290

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  • FBXW7 ubiquitin ligase is a component of the SCF complex and mediates degradation of several cell cycle proteins.

    “FBXW7 ubiquitin ligase is a component of the SCF complex and mediates degradation of several cell cycle proteins,158 and its β-isoform is induced by p53.159”

    From Census and evaluation of p53 target genes (2017) · cites this paper as [158]

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Authors
Welcker, M., & Clurman, B. E.
Affiliations
  • Fred Hutch Cancer Center (US)
  • University of Washington (US)
Corresponding author
Welcker, Markus
Venue
Nature Reviews Cancer
Published
2008-02
Volume
8
Issue
2
Pages
83-93
ISSN
  • 1474-175X (ISSN-L)
  • 1474-1768
OpenAlex
W2142183096
Cited by
1,084
References
120
Citations by year
2026: 33 · 2025: 34 · 2024: 34 · 2023: 38 · 2022: 53 · 2021: 67 · 2020: 64 · 2019: 69 · 2018: 67 · 2017: 68 · 2016: 74 · 2015: 77 · 2014: 73 · 2013: 82 · 2012: 76
FWCI
2.91
Type
journal article
Language
en
Open access
closed
Locations
  • Nature reviews. Cancer (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Heart, Lung, and Blood Institute (P01HL084205)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ubiquitin and proteasome pathways
  • Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Degradation and Inhibitors
Keywords
FBXW7, SCF ubiquitin ligase, tumour suppressor, MYC degradation, cyclin E, notches, c-Jun, chromosomal instability, carcinogenesis, cancer-associated mutations, cell division, cell growth, cell differentiation
MeSH terms
F-Box-WD Repeat-Containing Protein 7, Animals, Cell Differentiation, Cell Division, Humans, Models, Biological, Mutation, Neoplasms, Gene Expression Regulation, Neoplastic, Cell Cycle Proteins, Dimerization, Cyclin E, Ubiquitin-Protein Ligases, F-Box Proteins, Cell Proliferation, Mice

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