The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.
Insulin Signaling in Health and Disease
Abstract
The signaling pathways used by insulin have been identified [M. White, Insulin Signaling Pathway, Sci. STKE (Connections Map, as seen November 2003), http://stke.sciencemag.org/cgi/cm/cmp_12069]. Now our challenge is to understand how the failure of these signals is associated with obesity and the progressive failure of pancreatic beta cells that leads to diabetes. Whether better management of chronic inflammation can improve insulin action is an important area of investigation. Drugs that stimulate IRS2 (insulin receptor substrate protein 2) synthesis or signaling might be a good starting point. This knowledge will lead to rational strategies that prevent or cure diabetes.
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“Physiologically, IRS-1 is phosphorylated at tyrosine residues by the tyrosine kinase activity of the IR, which activates downstream signaling in the insulin pathway (Araki et al., 1994; White, 2003).”
From The Aβ oligomer hypothesis for synapse failure and memory loss in Alzheimer’s disease (2011) · cites this paper as White, 2003
Citations
Cites
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Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein
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Self-citationInsulin-regulated hepatic gluconeogenesis through FOXO1–PGC-1α interaction
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Insulin stimulates tyrosine phosphorylation of the insulin receptor in a cell-free system
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Insulin rapidly stimulates tyrosine phosphorylation of a Mr-185,000 protein in intact cells
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cAMP promotes pancreatic β-cell survival via CREB-mediated induction of IRS2Preprint
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Imaging Sites of Receptor Dephosphorylation by PTP1B on the Surface of the Endoplasmic Reticulum
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Upregulation of insulin receptor substrate-2 in pancreatic β cells prevents diabetes
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Flagged first, then by citations
Research works printed but not linked: 3
- M. White Insulin Signaling Pathway Sci. STKE (Connections Map as seen November 2003) http://stke.sciencemag.org/cgi/cm/cmp_12069.
- G. S. Hotamisligil, B. M. Spiegelman, Science259, 87 (1999).
- D. L. Krebs, D. J. Hilton, Sci. STKE.2003, E6 (2003).
Cited by
Sorted by citations
Mechanisms of type-I- and type-II-interferon-mediated signalling
Platanias, L. C. (2005) · Nature reviews. Immunology · doi:10.1038/nri1604 · Cited by 3,631
“These tyrosine residues are present in specific motifs such that, when phosphorylated, they function as binding sites for various signalling proteins that contain SH2 domains, including the p85 regulatory subunit of PI3”
BackgroundGlucagon-like peptide 1 (GLP-1)
Müller, T. D., Finan, B., Bloom, S. R., D'Alessio, D., Drucker, D. J., Flatt, P. R., Fritsche, A., Gribble, F., Grill, H. J., Habener, J. F., et al. (2019) · Molecular Metabolism · doi:10.1016/j.molmet.2019.09.010 · Cited by 1,868
“Consistent with this role of Irs2, increased expression of Irs2 in b-cells improves insulin secretion in obese mice and protects against STZ-induced b-cell destruction (as reviewed in [547]).”
BackgroundThe JNK signal transduction pathway
Weston, C. R. (2002) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(01)00258-1 · Cited by 1,551
Beyond PTEN mutations: the PI3K pathway as an integrator of multiple inputs during tumorigenesis
Cully, M., You, H., Levine, A. J., & Mak, T. W. (2006) · Nature reviews. Cancer · doi:10.1038/nrc1819 · Cited by 1,267
“For example, the inappropriate inhibition of the PI3K pathway has been associated with diseases as diverse as diabetes and schizophreni”
BackgroundDiabetes mellitus: The epidemic of the century
Kharroubi, A. (2015) · World Journal of Diabetes · doi:10.4239/wjd.v6.i6.850 · Cited by 1,352
Metadata
- Authors
- White, M. F.
- Affiliations
- Joslin Diabetes Center (US)
- Corresponding author
- White, Morris F.
- ORCID
- White, Morris F.
- Venue
- Science
- Published
- 2003-12-05
- Volume
- 302
- Issue
- 5651
- Pages
- 1710-1711
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2115177689
- Cited by
- 733
- References
- 19
- Citations by year
- 2026: 7 · 2025: 17 · 2024: 13 · 2023: 21 · 2022: 24 · 2021: 35 · 2020: 32 · 2019: 30 · 2018: 36 · 2017: 35 · 2016: 39 · 2015: 47 · 2014: 35 · 2013: 39 · 2012: 50
- FWCI
- 9.65
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- insulin signaling, insulin resistance, obesity, type 2 diabetes, pancreatic beta-cell failure, chronic inflammation, insulin receptor substrate 2
- MeSH terms
- Animals, Diabetes Mellitus, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2, Humans, Inflammation, Insulin, Insulin Resistance, Islets of Langerhans, Models, Biological, Obesity, Phosphoproteins, Phosphorylation, Receptor, Insulin, Somatomedins, Signal Transduction, Cytokines, Intracellular Signaling Peptides and Proteins, Mice, Insulin Receptor Substrate Proteins
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