The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Niemann-Pick C1 Like 1 Protein Is Critical for Intestinal Cholesterol Absorption
Abstract
Dietary cholesterol consumption and intestinal cholesterol absorption contribute to plasma cholesterol levels, a risk factor for coronary heart disease. The molecular mechanism of sterol uptake from the lumen of the small intestine is poorly defined. We show that Niemann-Pick C1Like 1(NPC1L1) protein plays a critical role in the absorption of intestinal cholesterol. NPC1L1 expression is enriched in the small intestine and is in the brush border membrane of enterocytes. Although otherwise phenotypically normal, NPC1L1-deficient mice exhibit a substantial reduction in absorbed cholesterol, which is unaffected by dietary supplementation of bile acids. Ezetimibe, a drug that inhibits cholesterol absorption, had no effect in NPC1L1 knockout mice, suggesting that NPC1L1 resides in an ezetimibe-sensitive pathway responsible for intestinal cholesterol absorption.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Genetic ablation of NPC1L1 or EZ administration impairs cholesterol absorption (6).”
From Aster-dependent nonvesicular transport facilitates dietary cholesterol uptake (2023) · cites this paper as [6]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
START: a lipid-binding domain in StAR, HD-ZIP and signalling proteins
Ponting, C. P., & Aravind, L. (1999) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(99)01362-6 · Cited by 398
Research works printed but not linked: 29
- 10.1038/nrd1112 · DOI · Paper page
- 10.1073/pnas.97.8.4245 · DOI · Paper page
- 10.1053/gast.2001.23250 · DOI
- 10.1021/bi982404y · DOI · Paper page
- 10.1126/science.289.5484.1524 · DOI · Paper page
- 10.1074/jbc.M301311200 · DOI · Paper page
- 10.1016/S1388-1981(01)00190-1 · DOI
- 10.1126/science.290.5497.1771 · DOI · Paper page
- 10.1038/83799 · DOI · Paper page
- 10.1038/82153 · DOI · Paper page
- 10.1016/S0022-2275(20)37489-7 · DOI
- 10.1126/science.74.1928.579 · DOI
- 10.1093/oxfordjournals.bmb.a069688 · doi:10.1093/oxfordjournals.bmb.a069688
- 10.1021/jm970701f · DOI · Paper page
- 10.1126/science.274.5289.998 · DOI · Paper page
- 10.1016/S0092-8674(00)81362-8 · DOI · Paper page
- 10.1016/S0021-9258(18)45190-3 · DOI
- 10.1006/geno.2000.6151 · DOI · Paper page
- 10.1038/308613a0 · DOI · Paper page
- 10.1126/science.272.5268.1668 · DOI · Paper page
- 10.1126/science.277.5323.228 · DOI · Paper page
- 10.1126/science.277.5323.232 · DOI · Paper page
- 10.1146/annurev.nu.03.070183.000443 · DOI · Paper page
- 10.1172/JCI104100 · doi:10.1172/jci104100
- 10.1016/S0022-2275(20)32171-4 · DOI · Paper page
- 10.1074/jbc.M007653200 · DOI · Paper page
- 10.1016/S0960-894X(01)00750-8 · DOI
- 10.1016/S0960-894X(01)00752-1 · DOI
- 10.1016/S0021-9258(19)44141-0 · DOI · Paper page
Cited by
Intestinal microbiota metabolism of l-carnitine, a nutrient in red meat, promotes atherosclerosis
Koeth, R. A., Wang, Z., Levison, B. S., Buffa, J. A., Org, E., Sheehy, B. T., Britt, E. B., Fu, X., Wu, Y., Li, L., et al. (2013) · Nature Medicine · doi:10.1038/nm.3145 · Cited by 4,386
Progress and challenges in translating the biology of atherosclerosis
Libby, P., Ridker, P. M., & Hansson, G. K. (2011) · Nature · doi:10.1038/nature10146 · Cited by 4,010
Mechanisms and regulation of cholesterol homeostasis
Luo, J., Yang, H., & Song, B.-L. (2020) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-019-0190-7 · Cited by 1,980
Lipids and Lipid-Based Formulations: Optimizing the Oral Delivery of Lipophilic Drugs
Porter, C. J. H., Trevaskis, N. L., & Charman, W. N. (2007) · Nature Reviews Drug Discovery · doi:10.1038/nrd2197 · Cited by 1,824
Dyslipidemia in obesity: Mechanisms and potential targets
Klop, B., Elte, J., & Cabezas, M. (2013) · Nutrients · doi:10.3390/nu5041218 · Cited by 1,665
Metadata
- Authors
- Altmann, S. W., Davis, H. R., Zhu, L.-J., Yao, X., Hoos, L. M., Tetzloff, G., Iyer, S. P. N., Maguire, M., Golovko, A., Zeng, M., Wang, L., Murgolo, N., & Graziano, M. P.
- Affiliations
- Department of Cardiovascular/Endocrine Research, Schering-Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, NJ, 07033–0539, USA.
- Venue
- Science
- Published
- 2004-02-20
- Volume
- 303
- Issue
- 5661
- Pages
- 1201-1204
- ISSN
- 0036-8075
- 1095-9203
- Cited by
- 1,577
- References
- 1
- Language
- en
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Niemann-Pick C1 Like 1 Protein Is Critical for Intestinal Cholesterol Absorption. https://app.cochat.ai/papers/10.1126/science.1093131
- The paper
- Altmann, S. W., Davis, H. R., Zhu, L.-J., Yao, X., Hoos, L. M., Tetzloff, G., Iyer, S. P. N., Maguire, M., Golovko, A., Zeng, M., Wang, L., Murgolo, N., & Graziano, M. P. (2004). Niemann-Pick C1 Like 1 Protein Is Critical for Intestinal Cholesterol Absorption. Science. https://doi.org/10.1126/science.1093131
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
