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Nanos Maintains Germline Stem Cell Self-Renewal by Preventing Differentiation
Abstract
Despite much progress in understanding how extrinsic signaling regulates stem cell self-renewal, little is known about how cell-autonomous gene regulation controls this process. In Drosophila ovaries, germline stem cells (GSCs) divide asymmetrically to produce daughter GSCs and cystoblasts, the latter of which develop into germline cysts. Here, we show that removing the translational repressor Nanos from either GSCs or their precursors, the primordial germ cells (PGCs), causes both cell types to differentiate into germline cysts. Thus, Nanos is essential for both establishing and maintaining GSCs by preventing their precocious entry into oogenesis. These functions are likely achieved by repressing the translation of differentiation factors in PGCs and GSCs.
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Cited by
Enhanced self-renewal of hematopoietic stem cells mediated by the polycomb gene product Bmi-1
Iwama, A., Oguro, H., Negishi, M., Kato, Y., Morita, Y., Tsukui, H., Ema, H., Kamijo, T., Katoh-Fukui, Y., Koseki, H., et al. (2004) · Immunity · doi:10.1016/j.immuni.2004.11.004 · Cited by 515
The RETINOBLASTOMA-RELATED Gene Regulates Stem Cell Maintenance in Arabidopsis Roots
Wildwater, M., Campilho, A., Perez-Perez, J. M., Heidstra, R., Blilou, I., Korthout, H., Chatterjee, J., Mariconti, L., Gruissem, W., & Scheres, B. (2005) · Cell · doi:10.1016/j.cell.2005.09.042 · Cited by 395
The RNA-Binding Protein NANOS2 Is Required to Maintain Murine Spermatogonial Stem Cells
Sada, A., Suzuki, A., Suzuki, H., & Saga, Y. (2009) · Science · doi:10.1126/science.1172645 · Cited by 305
Azlan, A., & Fukunaga, R. (2025) · PLOS Genetics · doi:10.1371/journal.pgen.1011792
(2025) · doi:10.7554/elife.103828.4
Metadata
- Authors
- Wang, Z., & Lin, H.
- Venue
- Science
- Published
- 2004-03-26
- Volume
- 303
- Issue
- 5666
- Pages
- 2016-2019
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2049255037
- Cited by
- 239
- References
- 0
- FWCI
- 6.01
- Type
- journal article
- Language
- en
- Open access
- closed
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- Wang, Z., & Lin, H. (2004). Nanos Maintains Germline Stem Cell Self-Renewal by Preventing Differentiation. Science. https://doi.org/10.1126/science.1093983
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