The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.
The RNA-Binding Protein NANOS2 Is Required to Maintain Murine Spermatogonial Stem Cells
Open accessAbstract
Maintaining Germline Stem Cells: Spermatogonial stem cell pools in postnatal testes have to be maintained to continuously generate spermatozoa. It has been difficult to identify these stem cells in vivo, because of their small numbers and lack of appropriate molecular markers, but now Sada et al. (p. 1394 ) show that the RNA-binding protein NANOS2 is expressed in a small subset of spermatogonia that behave as self-renewing stem cells in intact testes. By a combinatorial use of loss- and gain-of-function studies, NANOS2 was found to be essential for the maintenance of the immature state of spermatogonial stem cells by supporting their self-renewing properties and by suppressing differentiation.
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Cites
Essential role of Plzf in maintenance of spermatogonial stem cells
Costoya, J. A., Hobbs, R. M., Barna, M., Cattoretti, G., Manova, K., Sukhwani, M., Orwig, K. E., Wolgemuth, D. J., & Pandolfi, P. P. (2004) · Nature Genetics · doi:10.1038/ng1367 · Cited by 952
Plzf is required in adult male germ cells for stem cell self-renewal
Buaas, F. W., Kirsh, A. L., Sharma, M., McLean, D. J., Morris, J. L., Griswold, M. D., de Rooij, D. G., & Braun, R. E. (2004) · Nature Genetics · doi:10.1038/ng1366 · Cited by 890
All You Wanted to Know About Spermatogonia but Were Afraid to Ask
DE ROOIJ, D. G., & RUSSELL, L. D. (2000) · Journal of Andrology · doi:10.1002/j.1939-4640.2000.tb03408.x · Cited by 875
Conserved Role of nanos Proteins in Germ Cell Development
Tsuda, M., Sasaoka, Y., Kiso, M., Abe, K., Haraguchi, S., Kobayashi, S., & Saga, Y. (2003) · Science · doi:10.1126/science.1085222 · Cited by 577
Self-citationRegulation of Spermatogonial Stem Cell Self-Renewal in Mammals
Oatley, J. M., & Brinster, R. L. (2008) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.24.110707.175355 · Cited by 550
Proliferation and differentiation of spermatogonial stem cells
de Rooij, D. G. (2001) · Reproduction · doi:10.1530/rep.0.1210347 · Cited by 537
Nakagawa, T., Nabeshima, Y.-I., & Yoshida, S. (2007) · Developmental Cell · doi:10.1016/j.devcel.2007.01.002 · Cited by 398
Naughton, C. K., Jain, S., Strickland, A. M., Gupta, A., & Milbrandt, J. (2006) · Biology of Reproduction · doi:10.1095/biolreprod.105.047365 · Cited by 390
Drosophila Brain Tumor is a translational repressor
Sonoda, J., & Wharton, R. P. (2001) · Genes & Development · doi:10.1101/gad.870801 · Cited by 329
Nanos Maintains Germline Stem Cell Self-Renewal by Preventing Differentiation
Wang, Z., & Lin, H. (2004) · Science · doi:10.1126/science.1093983 · Cited by 239
Cited by
Strategies for Homeostatic Stem Cell Self-Renewal in Adult Tissues
Simons, B. D., & Clevers, H. (2011) · Cell · doi:10.1016/j.cell.2011.05.033 · Cited by 489
Metadata
- Authors
- Sada, A., Suzuki, A., Suzuki, H., & Saga, Y.
- Venue
- Science
- Published
- 2009-09-11
- Volume
- 325
- Issue
- 5946
- Pages
- 1394-1398
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2057641163
- Cited by
- 305
- References
- 15
- FWCI
- 25.01
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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