The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
Integrins, Rafts, Rac, and Rho
Abstract
It is known that processes such as cell migration involve adhesion of cells to the extracellular matrix via integrins. However, the integrin-mediated signaling events that help to regulate various cellular functions are still being elucidated. In his Perspective, Guan discusses new work ( del Pozo et al .; Palazzo et al .) demonstrating that integrins use plasma membrane lipid rafts to regulate the targeting of Rac and Rho GTPases to the plasma membrane and their coupling to downstream effector molecules.
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“Active GTP-bound Rac proteins are localized in plasma membrane domains, such as lipid rafts, to associate and activate downstream effector proteins.14,24,38,39”
From Cross-talk between RhoH and Rac1 in regulation of actin cytoskeleton and chemotaxis of hematopoietic progenitor cells (2008) · cites this paper as [39]
Citations
Cites
Hynes (2002) · doi:10.1016/s0092-8674(02)00971-6 · Cited by 8,606
Rho GTPases and the Actin Cytoskeleton
Hall, A. (1998) · Science · doi:10.1126/science.279.5350.509 · Cited by 6,193
Lipid rafts and signal transduction
Simons, K., & Toomre, D. (2000) · Nature Reviews Molecular Cell Biology · doi:10.1038/35036052 · Cited by 5,371
Structure and Function of Sphingolipid- and Cholesterol-rich Membrane Rafts
Brown, D. A., & London, E. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.r000005200 · Cited by 2,344
Focal adhesion kinase: the first ten years
Parsons, J. T. (2003) · Journal of Cell Science · doi:10.1242/jcs.00373 · Cited by 1,373
Sensing the environment: a historical perspective on integrin signal transduction
Miranti, C. K., & Brugge, J. S. (2002) · Nature Cell Biology · doi:10.1038/ncb0402-e83 · Cited by 877
mDia mediates Rho-regulated formation and orientation of stable microtubules
Palazzo, A. F., Cook, T. A., Alberts, A. S., & Gundersen, G. G. (2001) · Nature Cell Biology · doi:10.1038/35087035 · Cited by 611
Integrins Regulate Rac Targeting by Internalization of Membrane Domains
del Pozo, M. A., Alderson, N. B., Kiosses, W. B., Chiang, H.-H., Anderson, R. G. W., & Schwartz, M. A. (2004) · Science · doi:10.1126/science.1092571 · Cited by 475
del Pozo, M. Á., Price, L., Alderson, N. B., Ren, X., & Schwartz, M. A. (2000) · The EMBO Journal · doi:10.1093/emboj/19.9.2008 · Cited by 452
Localized Stabilization of Microtubules by Integrin- and FAK-Facilitated Rho Signaling
Palazzo, A. F., Eng, C. H., Schlaepfer, D. D., Marcantonio, E. E., & Gundersen, G. G. (2004) · Science · doi:10.1126/science.1091325 · Cited by 430
Cited by
Chae, H.-D., Lee, K. E., Williams, D. A., & Gu, Y. (2008) · Blood · doi:10.1182/blood-2007-06-093237 · Cited by 81
Isozyme-specific stimulation of phospholipase C-γ2 by Rac GTPases
Piechulek, T., Rehlen, T., Walliser, C., Vatter, P., Moepps, B., & Gierschik, P. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m509396200 · Cited by 80
Metadata
- Authors
- Guan, J.-L.
- Affiliations
- The author is in the Department of Molecular Medicine, Cornell University, Ithaca, NY 14853, USA.
- Venue
- Science
- Published
- 2004-02-06
- Volume
- 303
- Issue
- 5659
- Pages
- 773-774
- ISSN
- 0036-8075
- 1095-9203
- Cited by
- 58
- References
- 14
- Language
- en
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
