The DOI matches its Crossref record.
Evidence of a Pluripotent Human Embryonic Stem Cell Line Derived from a Cloned Blastocyst
Abstract
Somatic cell nuclear transfer (SCNT) technology has recently been used to generate animals with a common genetic composition. In this study, we report the derivation of a pluripotent embryonic stem (ES) cell line (SCNT-hES-1) from a cloned human blastocyst. The SCNT-hES-1 cells displayed typical ES cell morphology and cell surface markers and were capable of differentiating into embryoid bodies in vitro and of forming teratomas in vivo containing cell derivatives from all three embryonic germ layers in severe combined immunodeficient mice. After continuous proliferation for more than 70 passages, SCNT-hES-1 cells maintained normal karyotypes and were genetically identical to the somatic nuclear donor cells. Although we cannot completely exclude the possibility that the cells had a parthenogenetic origin, imprinting analyses support a SCNT origin of the derived human ES cells.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
Retracted Science and the Retraction Index
Fang, F. C., & Casadevall, A. (2011) · Infection and Immunity · doi:10.1128/iai.05661-11 · Cited by 405
RetractedFrom teratocarcinomas to embryonic stem cells and beyond: a history of embryonic stem cell research
Solter, D. (2006) · Nature Reviews Genetics · doi:10.1038/nrg1827 · Cited by 326
Responsible Conduct of Research
Shamoo, A. E., & Resnik, D. B. (2022) · doi:10.1093/oso/9780197547090.001.0001 · Cited by 224
Kennedy, D. (2006) · Science · doi:10.1126/science.1124926 · Cited by 117
RetractedDigital images are data: and should be treated as such
Cromey, D. W. (2012) · Methods in Molecular Biology · doi:10.1007/978-1-62703-056-4_1 · Cited by 82
Metadata
- Authors
- Hwang, W. S., Ryu, Y. J., Park, J. H., Park, E. S., Lee, E. G., Koo, J. M., Jeon, H. Y., Lee, B. C., Kang, S. K., Kim, S. J., Ahn, C., Hwang, J. H., Park, K. Y., Cibelli, J. B., & Moon, S. Y.
- Venue
- Science
- Published
- 2004-03-12
- Volume
- 303
- Issue
- 5664
- Pages
- 1669-1674
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2155143410
- Cited by
- 726
- References
- 0
- FWCI
- 43.08
- Type
- journal article
- Language
- en
- Status
- Retracted
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Evidence of a Pluripotent Human Embryonic Stem Cell Line Derived from a Cloned Blastocyst. https://app.cochat.ai/papers/10.1126/science.1094515
- The paper
- Hwang, W. S., Ryu, Y. J., Park, J. H., Park, E. S., Lee, E. G., Koo, J. M., Jeon, H. Y., Lee, B. C., Kang, S. K., Kim, S. J., Ahn, C., Hwang, J. H., Park, K. Y., Cibelli, J. B., & Moon, S. Y. (2004). Evidence of a Pluripotent Human Embryonic Stem Cell Line Derived from a Cloned Blastocyst. Science. https://doi.org/10.1126/science.1094515
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
