The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.
Protein Displacement by DExH/D "RNA Helicases" Without Duplex Unwinding
Abstract
Members of the DExH/D superfamily of nucleic acid–activated nucleotide triphosphatases are essential for virtually all aspects of RNA metabolism, including pre–messenger RNA splicing, RNA interference, translation, and nucleocytoplasmic trafficking. Physiological substrates for these enzymes are thought to be regions of double-stranded RNA, because several DExH/D proteins catalyze strand separation in vitro. These “RNA helicases” can also disrupt RNA-protein interactions, but it is unclear whether this activity is coupled to duplex unwinding. Here we demonstrate that two unrelated DExH/D proteins catalyze protein displacement independently of duplex unwinding. Therefore, the essential functions of DExH/D proteins are not confined to RNA duplexes but can be exerted on a wide range of ribonucleoprotein substrates.
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Cites
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How introns influence and enhance eukaryotic gene expression
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Active Disruption of an RNA-Protein Interaction by a DExH/D RNA Helicase
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Self-citationComposition and Functional Characterization of the Yeast Spliceosomal Penta-snRNP
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Cited by
The Nuclear Pore Complex and Nuclear Transport
Wente, S. R., & Rout, M. P. (2010) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a000562 · Cited by 686
Structural Basis for RNA Unwinding by the DEAD-Box Protein Drosophila Vasa
Sengoku, T., Nureki, O., Nakamura, A., Kobayashi, S., & Yokoyama, S. (2006) · Cell · doi:10.1016/j.cell.2006.01.054 · Cited by 573
Translocation and Unwinding Mechanisms of RNA and DNA Helicases
Pyle, A. M. (2008) · Annual Review of Biophysics · doi:10.1146/annurev.biophys.37.032807.125908 · Cited by 517
Structure of the Exon Junction Core Complex with a Trapped DEAD-Box ATPase Bound to RNA
Andersen, C. B. F., Ballut, L., Johansen, J. S., Chamieh, H., Nielsen, K. H., Oliveira, C. L. P., Pedersen, J. S., Séraphin, B., Hir, H. L., & Andersen, G. R. (2006) · Science · doi:10.1126/science.1131981 · Cited by 438
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Metadata
- Authors
- Fairman, M. E., Maroney, P. A., Wang, W., Bowers, H. A., Gollnick, P., Nilsen, T. W., & Jankowsky, E.
- Venue
- Science
- Published
- 2004-04-30
- Volume
- 304
- Issue
- 5671
- Pages
- 730-734
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2051537724
- Cited by
- 260
- References
- 19
- FWCI
- 9.73
- Type
- journal article
- Language
- en
- Open access
- closed
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- Fairman, M. E., Maroney, P. A., Wang, W., Bowers, H. A., Gollnick, P., Nilsen, T. W., & Jankowsky, E. (2004). Protein Displacement by DExH/D "RNA Helicases" Without Duplex Unwinding. Science. https://doi.org/10.1126/science.1095596
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