The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Axonal Neuregulin-1 Regulates Myelin Sheath Thickness
Abstract
In the nervous system of vertebrates, myelination is essential for rapid and accurate impulse conduction. Myelin thickness depends on axon fiber size. We use mutant and transgenic mouse lines to show that axonal Neuregulin-1 (Nrg1) signals information about axon size to Schwann cells. Reduced Nrg1 expression causes hypomyelination and reduced nerve conduction velocity. Neuronal overexpression of Nrg1 induces hypermyelination and demonstrates that Nrg1 type III is the responsible isoform. We suggest a model by which myelin-forming Schwann cells integrate axonal Nrg1 signals as a biochemical measure of axon size.
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Citations
Cites
Determinants of conduction velocity in myelinated nerve fibers
Waxman, S. G. (1980) · Muscle & Nerve · doi:10.1002/mus.880030207 · Cited by 629
Cited by
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Harrison, P. J., & Weinberger, D. R. (2005) · Molecular Psychiatry · doi:10.1038/sj.mp.4001558 · Cited by 2,020
Remyelination in the CNS: from biology to therapy
Franklin, R. J. M., & ffrench-Constant, C. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2480 · Cited by 1,544
Prenatal Infection and Schizophrenia: A Review of Epidemiologic and Translational Studies
Brown, A. S., & Derkits, E. J. (2010) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2009.09030361 · Cited by 1,269
Myelination and support of axonal integrity by glia
Nave, K.-A. (2010) · Nature · doi:10.1038/nature09614 · Cited by 1,062
Self-citationNeuregulin 1 in neural development, synaptic plasticity and schizophrenia
Mei, L., & Xiong, W.-C. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2392 · Cited by 1,030
Metadata
- Authors
- Michailov, G. V., Sereda, M. W., Brinkmann, B. G., Fischer, T. M., Haug, B., Birchmeier, C., Role, L., Lai, C., Schwab, M. H., & Nave, K.-A.
- Venue
- Science
- Published
- 2004-04-30
- Volume
- 304
- Issue
- 5671
- Pages
- 700-703
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2113404473
- Cited by
- 946
- References
- 1
- FWCI
- 15.52
- Type
- journal article
- Language
- en
- Open access
- closed
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- Michailov, G. V., Sereda, M. W., Brinkmann, B. G., Fischer, T. M., Haug, B., Birchmeier, C., Role, L., Lai, C., Schwab, M. H., & Nave, K.-A. (2004). Axonal Neuregulin-1 Regulates Myelin Sheath Thickness. Science. https://doi.org/10.1126/science.1095862
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
