The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Phospholipid Metabolism Regulated by a Transcription Factor Sensing Phosphatidic Acid
Abstract
Cells regulate the biophysical properties of their membranes by coordinated synthesis of different classes of lipids. Here, we identified a highly dynamic feedback mechanism by which the budding yeast Saccharomyces cerevisiae can regulate phospholipid biosynthesis. Phosphatidic acid on the endoplasmic reticulum directly bound to the soluble transcriptional repressor Opi1p to maintain it as inactive outside the nucleus. After the addition of the lipid precursor inositol, this phosphatidic acid was rapidly consumed, releasing Opi1p from the endoplasmic reticulum and allowing its nuclear translocation and repression of target genes. Thus, phosphatidic acid appears to be both an essential ubiquitous metabolic intermediate and a signaling lipid.
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Cites
Phosphatidic Acid-Mediated Mitogenic Activation of mTOR Signaling
Fang, Y., Vilella-Bach, M., Bachmann, R., Flanigan, A., & Chen, J. (2001) · Science · doi:10.1126/science.1066015 · Cited by 1,055
Schneiter, R., Brügger, B., Sandhoff, R., Zellnig, G., Leber, A., Lampl, M., Athenstaedt, K., Hrastnik, C., Eder, S., Daum, G., et al. (1999) · The Journal of Cell Biology · doi:10.1083/jcb.146.4.741 · Cited by 493
START: a lipid-binding domain in StAR, HD-ZIP and signalling proteins
Ponting, C. P., & Aravind, L. (1999) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(99)01362-6 · Cited by 398
Regulation of SREBP Processing and Membrane Lipid Production by Phospholipids in Drosophila
Dobrosotskaya, I. Y., Seegmiller, A. C., Brown, M. S., Goldstein, J. L., & Rawson, R. B. (2002) · Science · doi:10.1126/science.1071124 · Cited by 318
Cited by
Membrane recognition by phospholipid-binding domains
Lemmon, M. A. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2328 · Cited by 1,419
Signaling functions of phosphatidic acid
WANG, X., DEVAIAH, S., ZHANG, W., & WELTI, R. (2006) · Progress in Lipid Research · doi:10.1016/j.plipres.2006.01.005 · Cited by 757
Schuck, S., Prinz, W. A., Thorn, K. S., Voss, C., & Walter, P. (2009) · Journal of Cell Biology · doi:10.1083/jcb.200907074 · Cited by 580
Osh Proteins Regulate Phosphoinositide Metabolism at ER-Plasma Membrane Contact Sites
Stefan, C. J., Manford, A. G., Baird, D., Yamada-Hanff, J., Mao, Y., & Emr, S. D. (2011) · Cell · doi:10.1016/j.cell.2010.12.034 · Cited by 503
Molecular, cellular, and physiological responses to phosphatidic acid formation in plants
Testerink, C., & Munnik, T. (2011) · Journal of Experimental Botany · doi:10.1093/jxb/err079 · Cited by 409
Metadata
- Authors
- Loewen, C. J. R., Gaspar, M. L., Jesch, S. A., Delon, C., Ktistakis, N. T., Henry, S. A., & Levine, T. P.
- Venue
- Science
- Published
- 2004-06-11
- Volume
- 304
- Issue
- 5677
- Pages
- 1644-1647
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2011764708
- Cited by
- 491
- References
- 4
- FWCI
- 13.64
- Type
- journal article
- Language
- en
- Open access
- closed
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- Loewen, C. J. R., Gaspar, M. L., Jesch, S. A., Delon, C., Ktistakis, N. T., Henry, S. A., & Levine, T. P. (2004). Phospholipid Metabolism Regulated by a Transcription Factor Sensing Phosphatidic Acid. Science. https://doi.org/10.1126/science.1096083
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