Regulation of SREBP Processing and Membrane Lipid Production by Phospholipids in Drosophila
Abstract
Animal cells exert exquisite control over the physical and chemical properties of their membranes, but the mechanisms are obscure. We show that phosphatidylethanolamine, the major phospholipid in Drosophila , controls the release of sterol regulatory element–binding protein (SREBP) from Drosophila cell membranes, exerting feedback control on the synthesis of fatty acids and phospholipids. The finding that SREBP processing is controlled by different lipids in mammals and flies (sterols and phosphatidylethanolamine, respectively) suggests that an essential function of SREBP is to monitor cell membrane composition and to adjust lipid synthesis accordingly.
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D. melanogaster is a cholesterol auxotroph and activation of SREBP is regulated by reduced levels of palmitate and/or phospholipids.
“D. melanogaster is a cholesterol auxotroph and activation of SREBP is regulated by reduced levels of palmitate and/or phospholipids.”
From Expression of miR-33 from an SREBP2 Intron Inhibits Cholesterol Export and Fatty Acid Oxidation* (2010) · cites this paper as [39]
Homologs of SREBPs do not respond to changes in cholesterol, but rather changes in palmitate and/or phospholipids.
“It has been previously shown that the homologs of SREBPs do not respond to changes in cholesterol, but rather changes in palmitate and/or phospholipids (39,40).”
From Expression of miR-33 from an SREBP2 Intron Inhibits Cholesterol Export and Fatty Acid Oxidation* (2010) · cites this paper as [39]
Cites
The SREBP Pathway in Drosophila
Seegmiller, A. C., Dobrosotskaya, I., Goldstein, J. L., Ho, Y. K., Brown, M. S., & Rawson, R. B. (2002) · Developmental Cell · doi:10.1016/s1534-5807(01)00119-8 · Cited by 194 · see citing works
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The Opposing Effects of N-3 and n-6 Fatty Acids
Schmitz, G., & Ecker, J. (2008) · Progress in Lipid Research · doi:10.1016/j.plipres.2007.12.004 · Cited by 1,245 · see citing works
Glial Lipid Droplets and ROS Induced by Mitochondrial Defects Promote Neurodegeneration
Liu, L., Zhang, K., Sandoval, H., Yamamoto, S., Jaiswal, M., Sanz, E., Li, Z., Hui, J., Graham, B. H., Quintana, A., et al. (2015) · Cell · doi:10.1016/j.cell.2014.12.019 · Cited by 876 · see citing works
Regulation of Sterol Synthesis in Eukaryotes
Espenshade, P. J., & Hughes, A. L. (2007) · Annual Review of Genetics · doi:10.1146/annurev.genet.41.110306.130315 · Cited by 593 · see citing works
Sestrin as a feedback inhibitor of TOR that prevents age-related pathologies
Lee, J. H., Budanov, A. V., Park, E. J., Birse, R., Kim, T. E., Perkins, G. A., Ocorr, K., Ellisman, M. H., Bodmer, R., Bier, E., et al. (2010) · Science · doi:10.1126/science.1182228 · Cited by 570 · see citing works
Expression of miR-33 from an SREBP2 Intron Inhibits Cholesterol Export and Fatty Acid Oxidation*
Gerin, I., Clerbaux, L.-A., Haumont, O., Lanthier, N., Das, A. K., Burant, C. F., Leclercq, I. A., MacDougald, O. A., & Bommer, G. T. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.152090 · Cited by 382 · see citing works
SREBP pathway responds to sterols and functions as an oxygen sensor in fission yeast.
Hughes, A. L., Todd, B. L., & Espenshade, P. J. (2005) · Cell · doi:10.1016/j.cell.2005.01.012 · Cited by 320 · see citing works
Regulation of fatty acid and cholesterol synthesis: co-operation or competition?
Gibbons, G. F. (2003) · Progress in Lipid Research · doi:10.1016/s0163-7827(03)00034-1 · Cited by 51 · see citing works
- Authors
- Dobrosotskaya, I. Y., Seegmiller, A. C., Brown, M. S., Goldstein, J. L., & Rawson, R. B.
- Affiliations
- The University of Texas Southwestern Medical Center (US)
- Corresponding author
- Dobrosotskaya, I. Y.
- Seegmiller, A. C.
- Brown, M. S.
- Goldstein, J. L.
- Venue
- Science
- Published
- 2002-05-03
- Volume
- 296
- Issue
- 5569
- Pages
- 879-883
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2115670301
- Cited by
- 318
- References
- 1
- Citations by year
- 2026: 5 · 2025: 8 · 2024: 10 · 2023: 9 · 2022: 12 · 2021: 10 · 2020: 7 · 2019: 13 · 2018: 8 · 2017: 14 · 2016: 6 · 2015: 13 · 2014: 9 · 2013: 6 · 2012: 15
- FWCI
- 13.54
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Heart, Lung, and Blood Institute (HL-20948, P01HL020948)
- National Institute of General Medical Sciences (GM-08014, T32GM008014)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Lipids, and Metabolism
- Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
- Keywords
- SREBP, phosphatidylethanolamine, phospholipids, membrane lipid composition, fatty acid synthesis, lipid synthesis regulation, feedback control, Drosophila, sterols
- MeSH terms
- Animals, Cell Membrane, Cell Nucleus, Ceramides, Cholesterol, DNA-Binding Proteins, Drosophila, Enzyme Inhibitors, Fatty Acids, Fatty Acids, Monounsaturated, Membrane Lipids, Membrane Proteins, Palmitates, Phosphatidylcholines, Phosphatidylethanolamines, Phospholipids, RNA, Messenger, Transcription Factors, Gene Silencing, RNA, Untranslated, CCAAT-Enhancer-Binding Proteins, Feedback, Physiological, Drosophila Proteins, RNA, Small Interfering, Intracellular Signaling Peptides and Proteins, Sterol Regulatory Element Binding Protein 1
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