The DOI matches its Crossref record.
Modulation of Hematopoietic Stem Cell Homing and Engraftment by CD26
Abstract
Hematopoietic stem cell homing and engraftment are crucial to transplantation efficiency, and clinical engraftment is severely compromised when donor-cell numbers are limiting. The peptidase CD26 (DPPIV/dipeptidylpeptidase IV) removes dipeptides from the amino terminus of proteins. We present evidence that endogenous CD26 expression on donor cells negatively regulates homing and engraftment. By inhibition or deletion of CD26, it was possible to increase greatly the efficiency of transplantation. These results suggest that hematopoietic stem cell engraftment is not absolute, as previously suggested, and indicate that improvement of bone marrow transplant efficiency may be possible in the clinic.
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“the inhibition of CD26 by short term exposure of the donor cells to Diprotin A in vitro has been shown to increase transplantation efficiency in syngeneic murine and human xenotransplantation models[91,92].”
From Finding the needle in the hay stack: Hematopoietic stem cells in Fanconi anemia (2009) · cites this paper as [92]
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Research works printed but not linked: 30
- 10.1073/pnas.86.10.3828 · DOI
- 10.1056/NEJM198910263211707 · DOI
- H. E. Broxmeyer, F. Smith, in Thomas' Hematopoietic Cell Transplantation, K. G. Blume, S. J. Forman, F. R. Appelbaum, Eds. (Blackwell Science, Oxford; Malden, MA, 2004), chap. 43, pp. 550–564.
- 10.1053/bbmt.2002.v8.pm12171483 · DOI
- 10.1182/blood-2001-12-0290 · DOI
- 10.1016/S1074-7613(04)00002-0 · DOI
- 10.1038/ni940 · DOI
- 10.1016/S1074-7613(03)00354-6 · DOI
- 10.4049/jimmunol.169.12.7000 · DOI · Paper page
- 10.1182/blood-2002-12-3893 · DOI · Paper page
- 10.1016/S0301-472X(03)00256-X · DOI
- 10.1126/science.2898810 · DOI
- 10.1182/blood.V55.1.77.77 · DOI
- 10.1074/jbc.M309546200 · DOI
- 10.1084/jem.20011284 · DOI
- 10.1182/blood.V97.11.3354 · DOI
- H. E. Broxmeyer et al., Blood100, 609a (abstr. no. 2397) (2002).
- 10.1182/blood-2003-02-0663 · DOI
- 10.1126/science.283.5403.845 · DOI · Paper page
- 10.1007/BF02982544 · DOI
- 10.1016/S1074-7613(03)00201-2 · DOI
- 10.1182/blood.V91.1.100 · DOI
- 10.4049/jimmunol.170.1.421 · DOI
- 10.1189/jlb.1002495 · DOI · Paper page
- 10.1182/blood-2002-02-0564 · DOI
- D. E. Harrison, C. T. Jordan, R. K. Zhong, C. M. Astle, Exp. Hematol.21, 206 (1993).
- 10.1182/blood.V92.8.2641 · DOI
- 10.1182/blood-2002-07-1995 · DOI
- 10.1182/blood-2002-09-2782 · DOI
- 10.1038/nm886 · DOI
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Holmfeldt, P., Pardieck, J., Saulsberry, A. C., Nandakumar, S. K., Finkelstein, D., Gray, J. T., Persons, D. A., & McKinney-Freeman, S. (2013) · Blood · doi:10.1182/blood-2013-04-493973 · Cited by 55
Blood on the tracks: hematopoietic stem cell-endothelial cell interactions in homing and engraftment
Perlin, J. R., Sporrij, A., & Zon, L. I. (2017) · Journal of Molecular Medicine · doi:10.1007/s00109-017-1559-8 · Cited by 52
Insights into replicative senescence of human testicular peritubular cells
Schmid, N., Flenkenthaler, F., Stöckl, J. B., Dietrich, K.-G., Köhn, F. M., Schwarzer, J. U., Kunz, L., Luckner, M., Wanner, G., Arnold, G. J., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-51380-w · Cited by 49
Finding the needle in the hay stack: Hematopoietic stem cells in Fanconi anemia
Müller, L. U. W., & Williams, D. A. (2009) · Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis · doi:10.1016/j.mrfmmm.2009.03.010 · Cited by 31
Zhang, X., Tian, L., Majumdar, A., & Scheller, E. L. (2024) · Comprehensive Physiology · doi:10.1002/j.2040-4603.2024.tb00300.x · Cited by 18
Metadata
- Authors
- Christopherson, K. W., Hangoc, G., Mantel, C. R., & Broxmeyer, H. E.
- Affiliations
- Department of Microbiology and Immunology and the Walther Oncology Center, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
- Venue
- Science
- Published
- 2004-08-13
- Volume
- 305
- Issue
- 5686
- Pages
- 1000-1003
- ISSN
- 0036-8075
- 1095-9203
- Cited by
- 452
- References
- 0
- Language
- en
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