Nfix is a novel regulator of murine hematopoietic stem and progenitor cell survival
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Key Points: HSPCs fail to persist in the bone marrow of lethally irradiated recipients in the absence of Nfix. Nfix-deficient HSPCs display increased apoptosis during ex vivo culture and in recipient marrow.
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Although their loci are not very near to each other, Nfia, Nfib and Nfix regulate cell-type differentiation in many tissues, function as homo- or heterodimers, and bind to largely common targets.
“Although their loci are not very near to each other, Nfia, Nfib and Nfix regulate cell-type differentiation in many tissues94–96, function as homo- or heterodimers, and bind to largely common targets97.”
From A high-resolution transcriptomic and spatial atlas of cell types in the whole mouse brain (2023) · cites this paper as [95]
The Introduction (page unavailable) reports roles for Nfix in muscle and neural development and for Nfia in a blood-cell lineage switch; it also describes a lung-development defect in Nfib-deficient mice. This supports a broad developmental role for the family, but does not establish that all three genes regulate cell-type differentiation across many tissues. The separate citation attached to dimerization and common targets is not attributed to this paper. (LLM, conf=0.83)
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A high-resolution transcriptomic and spatial atlas of cell types in the whole mouse brain
Yao, Z., van Velthoven, C. T. J., Kunst, M., Zhang, M., McMillen, D., Lee, C., Jung, W., Goldy, J., Abdelhak, A., Aitken, M., et al. (2023) · Nature · doi:10.1038/s41586-023-06812-z · Cited by 1,194 · see citing works
Self-citation
- Authors
- Holmfeldt, P., Pardieck, J., Saulsberry, A. C., Nandakumar, S. K., Finkelstein, D., Gray, J. T., Persons, D. A., & McKinney-Freeman, S.
- Affiliations
- Department of Hematology and
- St. Jude Children's Research Hospital (US)
- ORCID
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2013-10-24
- Volume
- 122
- Issue
- 17
- Pages
- 2987-2996
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- PMC
- PMC3811173
- OpenAlex
- W1972259419
- Cited by
- 55
- References
- 32
- Citations by year
- 2026: 4 · 2025: 8 · 2024: 4 · 2023: 5 · 2022: 2 · 2021: 8 · 2020: 3 · 2019: 1 · 2018: 4 · 2017: 4 · 2016: 2 · 2015: 5 · 2014: 5
- FWCI
- 2.87
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Blood (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Cancer Institute (P30CA021765)
- National Institute of Diabetes and Digestive and Kidney Diseases (R03DK093731, K01DK080846)
- Topics
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Blood disorders and treatments
- Keywords
- NFIX, nuclear factor I, hematopoietic stem and progenitor cells, cell survival, apoptosis, bone marrow, transcription factors, ERG, MECOM, MPL, hematopoietic stem cell transplantation, gene expression profiling
- MeSH terms
- Transcriptional Regulator ERG, Animals, Antigens, Ly, Bone Marrow Cells, Cell Survival, Gene Expression Regulation, Hematopoiesis, Hematopoietic Stem Cells, Membrane Proteins, Transcription Factors, Signal Transduction, Oncogene Proteins, Apoptosis, Hematopoietic Stem Cell Transplantation, Proto-Oncogene Proteins c-kit, Gene Expression Profiling, RNA, Small Interfering, Mice, NFI Transcription Factors, Receptors, Thrombopoietin, Adult Stem Cells
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