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Regeneration of Male Germline Stem Cells by Spermatogonial Dedifferentiation in Vivo
Abstract
Although the ability of engrafted stem cells to regenerate tissue has received much attention, the molecular mechanisms controlling regeneration are poorly understood. In the Drosophila male germline, local activation of the Janus kinase–signal transducer and activator of transcription (Jak-STAT) pathway maintains stem cells; germline stem cells lacking Jak-STAT signaling differentiate into spermatogonia without self-renewal. By conditionally manipulating Jak-STAT signaling, we find that spermatogonia that have initiated differentiation and are undergoing limited mitotic (transit-amplifying) divisions can repopulate the niche and revert to stem cell identity. Thus, in the appropriate microenvironment, transit-amplifying cells dedifferentiate, becoming functional stem cells during tissue regeneration.
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Cited by
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Beachy, P. A., Karhadkar, S. S., & Berman, D. M. (2004) · Nature · doi:10.1038/nature03100 · Cited by 1,208
The adult human testis transcriptional cell atlas
Guo, J., Grow, E. J., Mlcochova, H., Maher, G. J., Lindskog, C., Nie, X., Guo, Y., Takei, Y., Yun, J., Cai, L., et al. (2018) · Cell Research · doi:10.1038/s41422-018-0099-2 · Cited by 710
The Germline Stem Cell Niche Unit in Mammalian Testes
Oatley, J. M., & Brinster, R. L. (2012) · Physiological Reviews · doi:10.1152/physrev.00025.2011 · Cited by 513
Adult cell plasticity in vivo: de-differentiation and transdifferentiation are back in style
Merrell, A. J., & Stanger, B. Z. (2016) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2016.24 · Cited by 369
Decline in Self-Renewal Factors Contributes to Aging of the Stem Cell Niche in the Drosophila Testis
Boyle, M., Wong, C., Rocha, M., & Jones, D. L. (2007) · Cell Stem Cell · doi:10.1016/j.stem.2007.08.002 · Cited by 268
Metadata
- Authors
- Brawley, C., & Matunis, E.
- Venue
- Science
- Published
- 2004-05-28
- Volume
- 304
- Issue
- 5675
- Pages
- 1331-1334
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1993076246
- Cited by
- 402
- References
- 0
- FWCI
- 20.20
- Type
- journal article
- Language
- en
- Open access
- closed
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