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NOBOX Deficiency Disrupts Early Folliculogenesis and Oocyte-Specific Gene Expression
Abstract
Primordial ovarian follicles in mice form when somatic cells surround individual oocytes. We show that lack of Nobox , an oocyte-specific homeobox gene, accelerates postnatal oocyte loss and abolishes the transition from primordial to growing follicles in mice. Follicles are replaced by fibrous tissue in female mice lacking Nobox in a manner similar to nonsyndromic ovarian failure in women. Genes preferentially expressed in oocytes, including Oct4 and Gdf9 , are down-regulated in Nobox –/– mice, whereas ubiquitous genes such as Bmp4, Kit , and Bax remain unaffected. Therefore, Nobox is critical for specifying an oocyte-restricted gene expression pattern essential for postnatal follicle development.
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Cited by
Oocyte formation by mitotically active germ cells purified from ovaries of reproductive-age women
White, Y. A. R., Woods, D. C., Takai, Y., Ishihara, O., Seki, H., & Tilly, J. L. (2012) · Nature Medicine · doi:10.1038/nm.2669 · Cited by 719
The ovary: basic biology and clinical implications
Richards, J. S., & Pangas, S. A. (2010) · Journal of Clinical Investigation · doi:10.1172/jci41350 · Cited by 561
Self-citationGenetics of primary ovarian insufficiency: new developments and opportunities
Qin, Y., Jiao, X., Simpson, J. L., & Chen, Z.-J. (2015) · Human Reproduction Update · doi:10.1093/humupd/dmv036 · Cited by 554
Molecular Mechanisms Underlying the Activation of Mammalian Primordial Follicles
Adhikari, D., & Liu, K. (2009) · Endocrine Reviews · doi:10.1210/er.2008-0048 · Cited by 481
Zhang, H., & Liu, K. (2015) · Human Reproduction Update · doi:10.1093/humupd/dmv037 · Cited by 274
Metadata
- Authors
- Rajkovic, A., Pangas, S. A., Ballow, D., Suzumori, N., & Matzuk, M. M.
- Venue
- Science
- Published
- 2004-08-20
- Volume
- 305
- Issue
- 5687
- Pages
- 1157-1159
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2089111937
- Cited by
- 569
- References
- 0
- FWCI
- 20.43
- Type
- journal article
- Language
- en
- Open access
- closed
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- Rajkovic, A., Pangas, S. A., Ballow, D., Suzumori, N., & Matzuk, M. M. (2004). NOBOX Deficiency Disrupts Early Folliculogenesis and Oocyte-Specific Gene Expression. Science. https://doi.org/10.1126/science.1099755
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