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The Complete Genome Sequence of Propionibacterium Acnes , a Commensal of Human Skin
Abstract
Propionibacterium acnes is a major inhabitant of adult human skin, where it resides within sebaceous follicles, usually as a harmless commensal although it has been implicated in acne vulgaris formation. The entire genome sequence of this Gram-positive bacterium encodes 2333 putative genes and revealed numerous gene products involved in degrading host molecules, including sialidases, neuraminidases, endoglycoceramidases, lipases, and pore-forming factors. Surface-associated and other immunogenic factors have been identified, which might be involved in triggering acne inflammation and other P. acnes –associated diseases.
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Citations
Cited by
Grice, E. A., & Segre, J. A. (2011) · Nature Reviews Microbiology · doi:10.1038/nrmicro2537 · Cited by 3,143
Byrd, A. L., Belkaid, Y., & Segre, J. A. (2018) · Nature Reviews Microbiology · doi:10.1038/nrmicro.2017.157 · Cited by 2,806
New developments in our understanding of acne pathogenesis and treatment
Kurokawa, I., Danby, F. W., Ju, Q., Wang, X., Xiang, L. F., Xia, L., Chen, W., Nagy, I., Picardo, M., Suh, D. H., et al. (2009) · Experimental Dermatology · doi:10.1111/j.1600-0625.2009.00890.x · Cited by 584
Nakatsuji, T., Kao, M. C., Fang, J.-Y., Zouboulis, C. C., Zhang, L., Gallo, R. L., & Huang, C.-M. (2009) · Journal of Investigative Dermatology · doi:10.1038/jid.2009.93 · Cited by 378
Nagy, I., Pivarcsi, A., Kis, K., Koreck, A., Bodai, L., McDowell, A., Seltmann, H., Patrick, S., Zouboulis, C. C., & Kemény, L. (2006) · Microbes and Infection · doi:10.1016/j.micinf.2006.04.001 · Cited by 375
Metadata
- Authors
- Brüggemann, H., Henne, A., Hoster, F., Liesegang, H., Wiezer, A., Strittmatter, A., Hujer, S., Dürre, P., & Gottschalk, G.
- Venue
- Science
- Published
- 2004-07-30
- Volume
- 305
- Issue
- 5684
- Pages
- 671-673
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2007128729
- Cited by
- 434
- References
- 0
- FWCI
- 21.19
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: The Complete Genome Sequence of Propionibacterium Acnes , a Commensal of Human Skin. https://app.cochat.ai/papers/10.1126/science.1100330
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- Brüggemann, H., Henne, A., Hoster, F., Liesegang, H., Wiezer, A., Strittmatter, A., Hujer, S., Dürre, P., & Gottschalk, G. (2004). The Complete Genome Sequence of Propionibacterium Acnes , a Commensal of Human Skin. Science. https://doi.org/10.1126/science.1100330
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.