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Hematotoxicity in Workers Exposed to Low Levels of Benzene
Open accessAbstract
Benzene is known to have toxic effects on the blood and bone marrow, but its impact at levels below the U.S. occupational standard of 1 part per million (ppm) remains uncertain. In a study of 250 workers exposed to benzene, white blood cell and platelet counts were significantly lower than in 140 controls, even for exposure below 1 ppm in air. Progenitor cell colony formation significantly declined with increasing benzene exposure and was more sensitive to the effects of benzene than was the number of mature blood cells. Two genetic variants in key metabolizing enzymes, myeloperoxidase and NAD(P)H:quinone oxidoreductase, influenced susceptibility to benzene hematotoxicity. Thus, hematotoxicity from exposure to benzene occurred at air levels of 1 ppm or less and may be particularly evident among genetically susceptible subpopulations.
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Cited by
Dinkova-Kostova, A. T., & Talalay, P. (2010) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2010.03.019 · Cited by 718
HOU, Y., WU, L., WANG, X., DING, Z., LI, Z., & FU, X. (2007) · Journal of Catalysis · doi:10.1016/j.jcat.2007.05.012 · Cited by 285
Current understandings and perspectives on non-cancer health effects of benzene: A global concern
Bahadar, H., Mostafalou, S., & Abdollahi, M. (2014) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2014.02.012 · Cited by 269
Loomis, D., Guyton, K. Z., Grosse, Y., El Ghissassi, F., Bouvard, V., Benbrahim-Tallaa, L., Guha, N., Vilahur, N., Mattock, H., & Straif, K. (2017) · The Lancet Oncology · doi:10.1016/s1470-2045(17)30832-x · Cited by 266
Therapy-related leukemia and myelodysplasia: susceptibility and incidence
Leone, G., Pagano, L., Ben-Yehuda, D., & Voso, M. T. (2007) · Haematologica · doi:10.3324/haematol.11034 · Cited by 236
Metadata
- Authors
- Lan, Q., Zhang, L., Li, G., Vermeulen, R., Weinberg, R. S., Dosemeci, M., Rappaport, S. M., Shen, M., Alter, B. P., Wu, Y., Kopp, W., Waidyanatha, S., Rabkin, C., Guo, W., Chanock, S., Hayes, R. B., Linet, M., Kim, S., Yin, S., Rothman, N., & Smith, M. T.
- Venue
- Science
- Published
- 2004-12-03
- Volume
- 306
- Issue
- 5702
- Pages
- 1774-1776
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2138876243
- Cited by
- 647
- References
- 0
- FWCI
- 9.92
- Type
- journal article
- Language
- en
- Open access
- green
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- Lan, Q., Zhang, L., Li, G., Vermeulen, R., Weinberg, R. S., Dosemeci, M., Rappaport, S. M., Shen, M., Alter, B. P., Wu, Y., Kopp, W., Waidyanatha, S., Rabkin, C., Guo, W., Chanock, S., Hayes, R. B., Linet, M., Kim, S., Yin, S., . . . Smith, M. T. (2004). Hematotoxicity in Workers Exposed to Low Levels of Benzene. Science. https://doi.org/10.1126/science.1102443
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