The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
A Host-Targeting Signal in Virulence Proteins Reveals a Secretome in Malarial Infection
Abstract
Malaria parasites secrete proteins across the vacuolar membrane into the erythrocyte, inducing modifications linked to disease and parasite survival. We identified an 11–amino acid signal required for the secretion of proteins from the Plasmodium falciparum vacuole to the human erythrocyte. Bioinformatics predicted a secretome of >320 proteins and conservation of the signal across parasite species. Functional studies indicated the predictive value of the signal and its role in targeting virulence proteins to the erythrocyte and implicated its recognition by a receptor/transporter. Erythrocyte modification by the parasite may involve plasmodial heat shock proteins and be vastly more complex than hitherto realized.
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Adherence of Plasmodium falciparum to Chondroitin Sulfate A in the Human Placenta
Fried, M., & Duffy, P. E. (1996) · Science · doi:10.1126/science.272.5267.1502 · Cited by 1,108
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Regev-Rudzki, N., Wilson, D. W., Carvalho, T. G., Sisquella, X., Coleman, B. M., Rug, M., Bursac, D., Angrisano, F., Gee, M., Hill, A. F., et al. (2013) · Cell · doi:10.1016/j.cell.2013.04.029 · Cited by 545
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Neduva, V., & Russell, R. B. (2005) · FEBS Letters · doi:10.1016/j.febslet.2005.04.005 · Cited by 352
Dou, D., Kale, S. D., Wang, X., Chen, Y., Wang, Q., Wang, X., Jiang, R. H. Y., Arredondo, F. D., Anderson, R. G., Thakur, P. B., et al. (2008) · The Plant Cell · doi:10.1105/tpc.107.057067 · Cited by 339
Metadata
- Authors
- Hiller, N. L., Bhattacharjee, S., van Ooij, C., Liolios, K., Harrison, T., Lopez-Estraño, C., & Haldar, K.
- Venue
- Science
- Published
- 2004-12-10
- Volume
- 306
- Issue
- 5703
- Pages
- 1934-1937
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2097432311
- Cited by
- 838
- References
- 2
- FWCI
- 43.72
- Type
- journal article
- Language
- en
- Open access
- closed
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- Hiller, N. L., Bhattacharjee, S., van Ooij, C., Liolios, K., Harrison, T., Lopez-Estraño, C., & Haldar, K. (2004). A Host-Targeting Signal in Virulence Proteins Reveals a Secretome in Malarial Infection. Science. https://doi.org/10.1126/science.1102737
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