Linear motifs: Evolutionary interaction switches
Abstract
Linear motifs are short sequence patterns associated with a particular function. They differ fundamentally from longer, globular protein domains in terms of their binding affinities, evolution and in how they are found experimentally or computationally. In this Minireview, we discuss various aspects of these critically important functional regions.
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Docking motifs are evolutionarily plastic solutions for forming new connections between signaling proteins because they can emerge in unstructured regions and their kinase binding specificity can be easily changed.
“They are evolutionarily plastic solutions for forming new connections between signaling proteins because they may freely emerge in unstructured protein regions and their binding specificity for kinases may also be easily changed (49).”
From Specificity of Linear Motifs That Bind to a Common Mitogen-Activated Protein Kinase Docking Groove (2012) · cites this paper as [49]
Linear motifs are frequently found in unstructured regions.
“Because linear motifs often occur in unstructured regions (49), we used DisEMBL 1.5 (61) to computationally predict amino acids belonging to an unstructured or disordered protein region.”
From Specificity of Linear Motifs That Bind to a Common Mitogen-Activated Protein Kinase Docking Groove (2012) · cites this paper as [49]
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- Authors
- Neduva, V., & Russell, R. B.
- Affiliations
- European Molecular Biology Laboratory (DE)
- Corresponding author
- Russell, Robert B.
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 2005-04-18
- Volume
- 579
- Issue
- 15
- Pages
- 3342-3345
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W1984164188
- Cited by
- 352
- References
- 40
- Citations by year
- 2026: 10 · 2025: 5 · 2024: 7 · 2023: 9 · 2022: 17 · 2021: 9 · 2020: 7 · 2019: 12 · 2018: 22 · 2017: 10 · 2016: 17 · 2015: 16 · 2014: 19 · 2013: 24 · 2012: 27
- FWCI
- 1.32
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- FEBS Letters (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Structure and Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Biochemical and Structural Characterization
- Keywords
- linear motifs, protein-protein interaction, protein evolution, sequence motifs, binding affinity, protein domains, protein function
- MeSH terms
- Amino Acid Sequence, Animals, Humans, Molecular Sequence Data, Nucleic Acids, Evolution, Molecular, Amino Acid Motifs
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