Cited by 352Protein Structure and DynamicsGenomics and Chromatin DynamicsBiochemical and Structural Characterization

Linear motifs: Evolutionary interaction switches

Neduva, Victor, Russell, Robert B.·2005·FEBS Letters

Abstract

Linear motifs are short sequence patterns associated with a particular function. They differ fundamentally from longer, globular protein domains in terms of their binding affinities, evolution and in how they are found experimentally or computationally. In this Minireview, we discuss various aspects of these critically important functional regions.

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Crossref · 10.1016/j.febslet.2005.04.005

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  • Docking motifs are evolutionarily plastic solutions for forming new connections between signaling proteins because they can emerge in unstructured regions and their kinase binding specificity can be easily changed.

    “They are evolutionarily plastic solutions for forming new connections between signaling proteins because they may freely emerge in unstructured protein regions and their binding specificity for kinases may also be easily changed (49).”
  • Linear motifs are frequently found in unstructured regions.

    “Because linear motifs often occur in unstructured regions (49), we used DisEMBL 1.5 (61) to computationally predict amino acids belonging to an unstructured or disordered protein region.”

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Authors
Neduva, V., & Russell, R. B.
Affiliations
European Molecular Biology Laboratory (DE)
Corresponding author
Russell, Robert B.
Venue
FEBS Letters
Publisher
Wiley
Published
2005-04-18
Volume
579
Issue
15
Pages
3342-3345
ISSN
  • 0014-5793 (ISSN-L)
  • 1873-3468
OpenAlex
W1984164188
Cited by
352
References
40
Citations by year
2026: 10 · 2025: 5 · 2024: 7 · 2023: 9 · 2022: 17 · 2021: 9 · 2020: 7 · 2019: 12 · 2018: 22 · 2017: 10 · 2016: 17 · 2015: 16 · 2014: 19 · 2013: 24 · 2012: 27
FWCI
1.32
Type
journal article
Language
en
Open access
closed
Locations
  • FEBS Letters (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Structure and Dynamics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Biochemical and Structural Characterization
Keywords
linear motifs, protein-protein interaction, protein evolution, sequence motifs, binding affinity, protein domains, protein function
MeSH terms
Amino Acid Sequence, Animals, Humans, Molecular Sequence Data, Nucleic Acids, Evolution, Molecular, Amino Acid Motifs

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