The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.
How Obesity Causes Diabetes: Not a Tall Tale
Abstract
The epidemic of obesity-associated diabetes is a major crisis in modern societies, in which food is plentiful and exercise is optional. The biological basis of this problem has been explored from evolutionary and mechanistic perspectives. Evolutionary theories, focusing on the potential survival advantages of “thrifty” genes that are now maladaptive, are of great interest but are inherently speculative and difficult to prove. Mechanistic studies have revealed numerous fat-derived molecules and a link to inflammation that, together, are hypothesized to underlie the obesity-diabetes connection and thereby represent prospective targets for therapeutic intervention.
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Citations
Cites
1 retracted
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Cited by
TOR signaling in growth and metabolism
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Identification and Importance of Brown Adipose Tissue in Adult Humans
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EDC-2: the endocrine society's second scientific statement on endocrine-disrupting chemicals
Gore, A. C., Chappell, V. A., Fenton, S. E., Flaws, J. A., Nadal, A., Prins, G. S., Toppari, J., & Zoeller, R. T. (2015) · Endocrine Reviews · doi:10.1210/er.2015-1010 · Cited by 2,407
Muscle as an Endocrine Organ: Focus on Muscle-Derived Interleukin-6
Pedersen, B. K., & Febbraio, M. A. (2008) · Physiological Reviews · doi:10.1152/physrev.90100.2007 · Cited by 2,388
Macrophage-specific PPARγ controls alternative activation and improves insulin resistance
Odegaard, J. I., Ricardo-Gonzalez, R. R., Goforth, M. H., Morel, C. R., Subramanian, V., Mukundan, L., Eagle, A. R., Vats, D., Brombacher, F., Ferrante, A. W., et al. (2007) · Nature · doi:10.1038/nature05894 · Cited by 2,107
Metadata
- Authors
- Lazar, M. A.
- Venue
- Science
- Published
- 2005-01-21
- Volume
- 307
- Issue
- 5708
- Pages
- 373-375
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2130684278
- Cited by
- 568
- References
- 18
- FWCI
- 35.99
- Type
- journal article
- Language
- en
- Open access
- closed
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- Lazar, M. A. (2005). How Obesity Causes Diabetes: Not a Tall Tale. Science. https://doi.org/10.1126/science.1104342
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
