The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.
Semaphorin 3E and Plexin-D1 Control Vascular Pattern Independently of Neuropilins
Abstract
The development of a patterned vasculature is essential for normal organogenesis. We found that signaling by semaphorin 3E (Sema3E) and its receptor plexin-D1 controls endothelial cell positioning and the patterning of the developing vasculature in the mouse. Sema3E is highly expressed in developing somites, where it acts as a repulsive cue for plexin-D1–expressing endothelial cells of adjacent intersomitic vessels. Sema3E–plexin-D1 signaling did not require neuropilins, which were previously presumed to be obligate Sema3 coreceptors. Moreover, genetic ablation of Sema3E or plexin-D1 but not neuropilin-mediated Sema3 signaling disrupted vascular patterning. These findings reveal an unexpected semaphorin signaling pathway and define a mechanism for controlling vascular patterning.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Soker, S., Takashima, S., Miao, H. Q., Neufeld, G., & Klagsbrun, M. (1998) · Cell · doi:10.1016/s0092-8674(00)81402-6 · Cited by 2,463
A requirement for neuropilin-1 in embryonic vessel formation
Kawasaki, T., Kitsukawa, T., Bekku, Y., Matsuda, Y., Sanbo, M., Yagi, T., & Fujisawa, H. (1999) · Development · doi:10.1242/dev.126.21.4895 · Cited by 827
Plexin-Neuropilin-1 Complexes Form Functional Semaphorin-3A Receptors
Takahashi, T., Fournier, A., Nakamura, F., Wang, L.-H., Murakami, Y., Kalb, R. G., Fujisawa, H., & Strittmatter, S. M. (1999) · Cell · doi:10.1016/s0092-8674(00)80062-8 · Cited by 817
Huber, A. B., Kolodkin, A. L., Ginty, D. D., & Cloutier, J.-F. (2003) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.26.010302.081139 · Cited by 719
Self-citationNeuropilin-1 Conveys Semaphorin and VEGF Signaling during Neural and Cardiovascular Development
Gu, C., Rodriguez, E. R., Reimert, D. V., Shu, T., Fritzsch, B., Richards, L. J., Kolodkin, A. L., & Ginty, D. D. (2003) · Developmental Cell · doi:10.1016/s1534-5807(03)00169-2 · Cited by 712
Self-citationClass 3 semaphorins control vascular morphogenesis by inhibiting integrin function
Serini, G., Valdembri, D., Zanivan, S., Morterra, G., Burkhardt, C., Caccavari, F., Zammataro, L., Primo, L., Tamagnone, L., Logan, M., et al. (2003) · Nature · doi:10.1038/nature01784 · Cited by 576
Plexin A Is a Neuronal Semaphorin Receptor that Controls Axon Guidance
Winberg, M. L., Noordermeer, J. N., Tamagnone, L., Comoglio, P. M., Spriggs, M. K., Tessier-Lavigne, M., & Goodman, C. S. (1998) · Cell · doi:10.1016/s0092-8674(00)81715-8 · Cited by 470
Semaphorins and their receptors in vertebrates and invertebrates
Raper, J. A. (2000) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(99)00057-4 · Cited by 459
The Semaphorin 4D receptor controls invasive growth by coupling with Met
Giordano, S., Corso, S., Conrotto, P., Artigiani, S., Gilestro, G., Barberis, D., Tamagnone, L., & Comoglio, P. M. (2002) · Nature Cell Biology · doi:10.1038/ncb843 · Cited by 444
PlexinD1 and Semaphorin Signaling Are Required in Endothelial Cells for Cardiovascular Development
Gitler, A. D., Lu, M. M., & Epstein, J. A. (2004) · Developmental Cell · doi:10.1016/j.devcel.2004.06.002 · Cited by 371
Cited by
Common mechanisms of nerve and blood vessel wiring
Carmeliet, P., & Tessier-Lavigne, M. (2005) · Nature · doi:10.1038/nature03875 · Cited by 1,085
Molecular control of endothelial cell behaviour during blood vessel morphogenesis
Herbert, S. P., & Stainier, D. Y. R. (2011) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3176 · Cited by 1,042
Daneman, R., Zhou, L., Agalliu, D., Cahoy, J. D., Kaushal, A., & Barres, B. A. (2010) · PLoS ONE · doi:10.1371/journal.pone.0013741 · Cited by 577
Dynamics of endothelial cell behavior in sprouting angiogenesis
Eilken, H. M., & Adams, R. H. (2010) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2010.08.010 · Cited by 561
Semaphorins and their Signaling Mechanisms
Alto, L. T., & Terman, J. R. (2017) · Methods in Molecular Biology · doi:10.1007/978-1-4939-6448-2_1 · Cited by 429
Metadata
- Authors
- Gu, C., Yoshida, Y., Livet, J., Reimert, D. V., Mann, F., Merte, J., Henderson, C. E., Jessell, T. M., Kolodkin, A. L., & Ginty, D. D.
- Venue
- Science
- Published
- 2005-01-14
- Volume
- 307
- Issue
- 5707
- Pages
- 265-268
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2092641793
- Cited by
- 543
- References
- 19
- FWCI
- 10.60
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Semaphorin 3E and Plexin-D1 Control Vascular Pattern Independently of Neuropilins. https://app.cochat.ai/papers/10.1126/science.1105416
- The paper
- Gu, C., Yoshida, Y., Livet, J., Reimert, D. V., Mann, F., Merte, J., Henderson, C. E., Jessell, T. M., Kolodkin, A. L., & Ginty, D. D. (2005). Semaphorin 3E and Plexin-D1 Control Vascular Pattern Independently of Neuropilins. Science. https://doi.org/10.1126/science.1105416
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
