The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Aconitase Couples Metabolic Regulation to Mitochondrial DNA Maintenance
Abstract
Mitochondrial DNA (mtDNA) is essential for cells to maintain respiratory competency and is inherited as a protein-DNA complex called the nucleoid. We have identified 22 mtDNA-associated proteins in yeast, among which is mitochondrial aconitase (Aco1p). We show that this Krebs-cycle enzyme is essential for mtDNA maintenance independent of its catalytic activity. Regulation of ACO1 expression by the HAP and retrograde metabolic signaling pathways directly affects mtDNA maintenance. When constitutively expressed, Aco1p can replace the mtDNA packaging function of the high-mobility-group protein Abf2p. Thus, Aco1p may integrate metabolic signals and mtDNA maintenance.
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Cites
Genome-wide responses to mitochondrial dysfunction
Epstein, C. B., Waddle, J. A., Hale, W., Davé, V., Thornton, J., Macatee, T. L., Garner, H. R., & Butow, R. A. (2001) · Molecular Biology of the Cell · doi:10.1091/mbc.12.2.297 · Cited by 389
Self-citationClinical, biochemical and molecular genetic correlations in Friedreich's ataxia
Bradley, J. L. (2000) · Human Molecular Genetics · doi:10.1093/hmg/9.2.275 · Cited by 339
Liu, Z., & Butow, R. A. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.10.6720 · Cited by 290
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Cited by
Mitochondrial retrograde signaling
Liu, Z., & Butow, R. A. (2006) · Annual Review of Genetics · doi:10.1146/annurev.genet.40.110405.090613 · Cited by 680
Self-citationHogan, D. J., Riordan, D. P., Gerber, A. P., Herschlag, D., & Brown, P. O. (2008) · PLoS Biology · doi:10.1371/journal.pbio.0060255 · Cited by 609
Oxidative stress and pulmonary fibrosis
Cheresh, P., Kim, S.-J., Tulasiram, S., & Kamp, D. W. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2012.11.021 · Cited by 530
Kaufman, B. A., Durisic, N., Mativetsky, J. M., Costantino, S., Hancock, M. A., Grutter, P., & Shoubridge, E. A. (2007) · Molecular Biology of the Cell · doi:10.1091/mbc.e07-05-0404 · Cited by 427
Self-citationMoonlighting proteins: an intriguing mode of multitasking
Huberts, D. H. E. W., & van der Klei, I. J. (2010) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2010.01.022 · Cited by 405
Metadata
- Authors
- Chen, X. J., Wang, X., Kaufman, B. A., & Butow, R. A.
- Venue
- Science
- Published
- 2005-02-04
- Volume
- 307
- Issue
- 5710
- Pages
- 714-717
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2165988320
- Cited by
- 314
- References
- 3
- FWCI
- 9.56
- Type
- journal article
- Language
- en
- Open access
- closed
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- Chen, X. J., Wang, X., Kaufman, B. A., & Butow, R. A. (2005). Aconitase Couples Metabolic Regulation to Mitochondrial DNA Maintenance. Science. https://doi.org/10.1126/science.1106391
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