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Structure of the ABC Transporter MsbA in Complex with ADP·Vanadate and Lipopolysaccharide
Abstract
Select members of the adenosine triphosphate (ATP)-binding cassette (ABC) transporter family couple ATP binding and hydrolysis to substrate efflux and confer multidrug resistance. We have determined the x-ray structure of MsbA in complex with magnesium, adenosine diphosphate, and inorganic vanadate (Mg·ADP·V i ) and the rough-chemotype lipopolysaccharide, Ra LPS. The structure supports a model involving a rigid-body torque of the two transmembrane domains during ATP hydrolysis and suggests a mechanism by which the nucleotide-binding domain communicates with the transmembrane domain. We propose a lipid “flip-flop” mechanism in which the sugar groups are sequestered in the chamber while the hydrophobic tails are dragged through the lipid bilayer.
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Innate Immunity: The Virtues of a Nonclonal System of Recognition
Medzhitov, R., & Janeway, C. A. (1997) · Cell · doi:10.1016/s0092-8674(00)80412-2 · Cited by 2,434
Smith, P. C., Karpowich, N., Millen, L., Moody, J. E., Rosen, J., Thomas, P. J., & Hunt, J. F. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00576-2 · Cited by 773
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Deeley, R. G., Westlake, C., & Cole, S. P. C. (2006) · Physiological Reviews · doi:10.1152/physrev.00035.2005 · Cited by 761
Wza the translocon for E. coli capsular polysaccharides defines a new class of membrane protein
Dong, C., Beis, K., Nesper, J., Brunkan-LaMontagne, A. L., Clarke, B. R., Whitfield, C., & Naismith, J. H. (2006) · Nature · doi:10.1038/nature05267 · Cited by 373
ABC Transporters Involved in Export of Cell Surface Glycoconjugates
Cuthbertson, L., Kos, V., & Whitfield, C. (2010) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00009-10 · Cited by 198
3‐D structural and functional characterization of the purified KATP channel complex Kir6.2–SUR1
Mikhailov, M. V., Campbell, J. D., de Wet, H., Shimomura, K., Zadek, B., Collins, R. F., Sansom, M. S., Ford, R. C., & Ashcroft, F. M. (2005) · The EMBO Journal · doi:10.1038/sj.emboj.7600877 · Cited by 168
Metadata
- Authors
- Reyes, C. L., & Chang, G.
- Venue
- Science
- Published
- 2005-05-13
- Volume
- 308
- Issue
- 5724
- Pages
- 1028-1031
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1629774220
- Cited by
- 161
- References
- 2
- FWCI
- 15.55
- Type
- journal article
- Language
- en
- Status
- Retracted
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
