The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Amplification of Acetylcholine-Binding Catenanes from Dynamic Combinatorial Libraries
Abstract
Directed chemical synthesis can produce a vast range of molecular structures, but the intended product must be known at the outset. In contrast, evolution in nature can lead to efficient receptors and catalysts whose structures defy prediction. To access such unpredictable structures, we prepared dynamic combinatorial libraries in which reversibly binding building blocks assemble around a receptor target. We selected for an acetylcholine receptor by adding the neurotransmitter to solutions of dipeptide hydrazones [proline-phenylalanine or proline-(cyclohexyl)alanine], which reversibly combine through hydrazone linkages. At thermodynamic equilibrium, the dominant receptor structure was an elaborate [2]-catenane consisting of two interlocked macrocyclic trimers. This complex receptor with a 100 nM affinity for acetylcholine could be isolated on a preparative scale in 67% yield.
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Rowan, S. J., Cantrill, S. J., Cousins, G. R. L., Sanders, J. K. M., & Stoddart, J. F. (2002) · Angewandte Chemie International Edition · doi:10.1002/1521-3773(20020315)41:6<898::aid-anie898>3.0.co;2-e · Cited by 2,588
Self-citationDynamic Combinatorial Chemistry
Corbett, P. T., Leclaire, J., Vial, L., West, K. R., Wietor, J.-L., Sanders, J. K. M., & Otto, S. (2006) · Chemical Reviews · doi:10.1021/cr020452p · Cited by 1,922
Self-citationRuhland, K. (2020) · Catalysis from A to Z · doi:10.1002/9783527809080.cataz06077 · Cited by 1,724
Drug discovery by dynamic combinatorial libraries
Ramström, O., & Lehn, J.-M. (2002) · Nature Reviews Drug Discovery · doi:10.1038/nrd704 · Cited by 511
Dynamic Combinatorial Chemistry
Lehn, J.-M., & Eliseev, A. V. (2001) · Science · doi:10.1126/science.1060066 · Cited by 403
Selection and Amplification of Hosts From Dynamic Combinatorial Libraries of Macrocyclic Disulfides
Otto, S., Furlan, R. L. E., & Sanders, J. K. M. (2002) · Science · doi:10.1126/science.1072361 · Cited by 386
Self-citationOtto, S., & Kubik, S. (2003) · Journal of the American Chemical Society · doi:10.1021/ja0351589 · Cited by 191
Self-citationSelection and Amplification of a Catalyst from a Dynamic Combinatorial Library
Brisig, B., Sanders, J. K. M., & Otto, S. (2003) · Angewandte Chemie International Edition · doi:10.1002/anie.200390326 · Cited by 164
Self-citationCorbett, P. T., Otto, S., & Sanders, J. K. M. (2004) · Chemistry - A European Journal · doi:10.1002/chem.200400300 · Cited by 120
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Dynamic Combinatorial Chemistry
Corbett, P. T., Leclaire, J., Vial, L., West, K. R., Wietor, J.-L., Sanders, J. K. M., & Otto, S. (2006) · Chemical Reviews · doi:10.1021/cr020452p · Cited by 1,922
Self-citationPrebiotic Systems Chemistry: New Perspectives for the Origins of Life
Ruiz-Mirazo, K., Briones, C., & de la Escosura, A. (2014) · Chemical Reviews · doi:10.1021/cr2004844 · Cited by 930
Functional behaviour from controlled self-assembly: challenges and prospects
Ward, M. D., & Raithby, P. R. (2013) · Chem. Soc. Rev. · doi:10.1039/c2cs35123d · Cited by 444
Prebiotic Peptides: Molecular Hubs in the Origin of Life
Frenkel-Pinter, M., Samanta, M., Ashkenasy, G., & Leman, L. J. (2020) · Chemical Reviews · doi:10.1021/acs.chemrev.9b00664 · Cited by 354
Herrmann, A. (2014) · Chem. Soc. Rev. · doi:10.1039/c3cs60336a · Cited by 351
Metadata
- Authors
- Lam, R. T. S., Belenguer, A., Roberts, S. L., Naumann, C., Jarrosson, T., Otto, S., & Sanders, J. K. M.
- Venue
- Science
- Published
- 2005-04-29
- Volume
- 308
- Issue
- 5722
- Pages
- 667-669
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2142177769
- Cited by
- 299
- References
- 9
- FWCI
- 13.89
- Type
- journal article
- Language
- en
- Open access
- closed
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- Lam, R. T. S., Belenguer, A., Roberts, S. L., Naumann, C., Jarrosson, T., Otto, S., & Sanders, J. K. M. (2005). Amplification of Acetylcholine-Binding Catenanes from Dynamic Combinatorial Libraries. Science. https://doi.org/10.1126/science.1109999
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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