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Early Asymmetry of Gene Transcription in Embryonic Human Left and Right Cerebral Cortex
Open accessAbstract
The human left and right cerebral hemispheres are anatomically and functionally asymmetric. To test whether human cortical asymmetry has a molecular basis, we studied gene expression levels between the left and right embryonic hemispheres using serial analysis of gene expression (SAGE). We identified and verified 27 differentially expressed genes, which suggests that human cortical asymmetry is accompanied by early, marked transcriptional asymmetries. LMO4 is consistently more highly expressed in the right perisylvian human cerebral cortex than in the left and is essential for cortical development in mice, suggesting that human left-right specialization reflects asymmetric cortical development at early stages.
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Cited by
Spatio-temporal transcriptome of the human brain
Kang, H. J., Kawasawa, Y. I., Cheng, F., Zhu, Y., Xu, X., Li, M., Sousa, A. M. M., Pletikos, M., Meyer, K. A., Sedmak, G., et al. (2011) · Nature · doi:10.1038/nature10523 · Cited by 2,084
Evolution of the neocortex: a perspective from developmental biology
Rakic, P. (2009) · Nature reviews. Neuroscience · doi:10.1038/nrn2719 · Cited by 1,565
Johnson, M. H. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1766 · Cited by 969
Molecular logic of neocortical projection neuron specification, development and diversity
Greig, L. C., Woodworth, M. B., Galazo, M. J., Padmanabhan, H., & Macklis, J. D. (2013) · Nature Reviews Neuroscience · doi:10.1038/nrn3586 · Cited by 863
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Sur, M., & Rubenstein, J. L. R. (2005) · Science · doi:10.1126/science.1112070 · Cited by 677
Metadata
- Authors
- Sun, T., Patoine, C., Abu-Khalil, A., Visvader, J., Sum, E., Cherry, T. J., Orkin, S. H., Geschwind, D. H., & Walsh, C. A.
- Venue
- Science
- Published
- 2005-06-17
- Volume
- 308
- Issue
- 5729
- Pages
- 1794-1798
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2049734059
- Cited by
- 352
- References
- 0
- FWCI
- 9.80
- Type
- journal article
- Language
- en
- Open access
- green
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- Sun, T., Patoine, C., Abu-Khalil, A., Visvader, J., Sum, E., Cherry, T. J., Orkin, S. H., Geschwind, D. H., & Walsh, C. A. (2005). Early Asymmetry of Gene Transcription in Embryonic Human Left and Right Cerebral Cortex. Science. https://doi.org/10.1126/science.1110324
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