Cited by 652Phosphodiesterase function and regulationSchizophrenia research and treatmentProtein Tyrosine Phosphatases

The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.

DISC1 and PDE4B Are Interacting Genetic Factors in Schizophrenia That Regulate cAMP Signaling

Millar, J. Kirsty, Pickard, Benjamin S., Mackie, Shaun, James, Rachel, Christie, Sheila, Buchanan, Sebastienne R., Malloy, M. Pat, Chubb, Jennifer E., Huston, Elaine, Baillie, George S., Thomson, Pippa A., Hill, Elaine V., Brandon, Nicholas J., Rain, Jean-Christophe, Camargo, L. Miguel, Whiting, Paul J., Houslay, Miles D., Blackwood, Douglas H. R., Muir, Walter J., Porteous, David J.·2005·Science

DOI 10.1126/science.1112915

Open this paper in CoChat — free account

Abstract

The disrupted in schizophrenia 1 ( DISC1 ) gene is a candidate susceptibility factor for schizophrenia, but its mechanistic role in the disorder is unknown. Here we report that the gene encoding phosphodiesterase 4B ( PDE4B ) is disrupted by a balanced translocation in a subject diagnosed with schizophrenia and a relative with chronic psychiatric illness. The PDEs inactivate adenosine 3′,5′-monophosphate (cAMP), a second messenger implicated in learning, memory, and mood. We show that DISC1 interacts with the UCR2 domain of PDE4B and that elevation of cellular cAMP leads to dissociation of PDE4B from DISC1 and an increase in PDE4B activity. We propose a mechanistic model whereby DISC1 sequesters PDE4B in resting cells and releases it in an activated state in response to elevated cAMP.

Integrity signals

Registry

Crossref · 10.1126/science.1112915

Cites

20 of 20 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Schizophrenia genes, gene expression, and neuropathology: on the matter of their convergence
Harrison, P. J., & Weinberger, D. R. (2005) · Molecular Psychiatry · doi:10.1038/sj.mp.4001558 · Cited by 2,020
Disruption of two novel genes by a translocation co-segregating with schizophrenia
Millar, J. K. (2000) · Human Molecular Genetics · doi:10.1093/hmg/9.9.1415 · Cited by 1,254
Self-citation
PDE4 cAMP phosphodiesterases: modular enzymes that orchestrate signalling cross-talk, desensitization and compartmentalization
Houslay, M. D., & Adams, D. R. (2003) · Biochemical Journal · doi:10.1042/bj20021698 · Cited by 768
Self-citation
Schizophrenia and Affective Disorders—Cosegregation with a Translocation at Chromosome 1q42 That Directly Disrupts Brain-Expressed Genes: Clinical and P300 Findings in a Family
Blackwood, D., Fordyce, A., Walker, M. T., Clair, D. M. S., Porteous, D. J., & Muir, W. J. (2001) · The American Journal of Human Genetics · doi:10.1086/321969 · Cited by 734
Self-citation
Phosphorylation and Activation of a cAMP-specific Phosphodiesterase by the cAMP-dependent Protein Kinase
Sette, C., & Conti, M. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.28.16526 · Cited by 412
Disrupted-In-Schizophrenia 1, a candidate gene for schizophrenia, participates in neurite outgrowth
Miyoshi, K., Honda, A., Baba, K., Taniguchi, M., Oono, K., Fujita, T., Kuroda, S., Katayama, T., & Tohyama, M. (2003) · Molecular Psychiatry · doi:10.1038/sj.mp.4001352 · Cited by 314
Antidepressant effects of inhibitors of cAMP phosphodiesterase (PDE4)
O’Donnell, J. M., & Zhang, H. (2004) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2004.01.003 · Cited by 307
Long PDE4 cAMP specific phosphodiesterases are activated by protein kinase A‐mediated phosphorylation of a single serine residue in Upstream Conserved Region 1 (UCR1)
MacKenzie, S. J., Baillie, G. S., McPhee, I., MacKenzie, C., SEAMONS, R. A., McSorley, T., Millen, J. E., Beard, M., Heeke, G. V., & Houslay, M. D. (2002) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0704743 · Cited by 261
Self-citation
Antidepressant-like Profile and Reduced Sensitivity to Rolipram in Mice Deficient in the PDE4D Phosphodiesterase Enzyme
Zhang, H. (2002) · Neuropsychopharmacology · doi:10.1016/s0893-133x(02)00344-5 · Cited by 228
Disrupted in Schizophrenia 1 and Nudel form a neurodevelopmentally regulated protein complex: implications for schizophrenia and other major neurological disorders
Brandon, N. J., Handford, E. J., Schurov, I., Rain, J., Pelling, M., Duran-Jimenez, B., Camargo, L. M., Oliver, K. R., Beher, D., Shearman, M. S., et al. (2003) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2003.09.009 · Cited by 224
Self-citation

Flagged first, then by citations

Show all 20 references

Research works printed but not linked: 2

C. P. Austin, L. Ma, B. Ky, J. A. Morris, P. J. Shugrue, Neuroreport14, 951 (2003).
H. T. Zhang et al., Neuropsychopharmacology27, 587 (2002).

Sorted by citations

Items 301–400 of 652

Associating schizophrenia, long non-coding RNAs and neurostructural dynamics
Merelo, V., Durand, D., Lescallette, A. R., Vrana, K. E., Hong, L. E., Faghihi, M. A., & Bellon, A. (2015) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2015.00057 · Cited by 38
Therapeutic benefits of phosphodiesterase 4B inhibition after traumatic brain injury
Wilson, N. M., Gurney, M. E., Dietrich, W. D., & Atkins, C. M. (2017) · PLoS ONE · doi:10.1371/journal.pone.0178013 · Cited by 38
FBXW7 regulates DISC1 stability via the ubiquitin-proteosome system
Yalla, K., Elliott, C., Day, J., Findlay, J., Barratt, S., Hughes, Z., Wilson, L., Whiteley, E., Popiolek, M., Li, Y., et al. (2017) · Molecular Psychiatry · doi:10.1038/mp.2017.138 · Cited by 34
Self-citation
Group Sparse Joint Non-Negative Matrix Factorization on Orthogonal Subspace for Multi-Modal Imaging Genetics Data Analysis
Peng, P., Zhang, Y., Ju, Y., Wang, K., Li, G., Calhoun, V. D., & Wang, Y. (2020) · IEEE Transactions on Computational Biology and Bioinformatics · doi:10.1109/tcbb.2020.2999397 · Cited by 37
Phosphodiesterase-4A expression is reduced in cerebella of patients with bipolar disorder
Fatemi, S. H., Reutiman, T. J., Folsom, T. D., & Lee, S. S. (2008) · Psychiatric Genetics · doi:10.1097/ypg.0b013e3283060fb8 · Cited by 36
The PDE4 cAMP-Specific Phosphodiesterases: Targets for Drugs with Antidepressant and Memory-Enhancing Action
Bolger, G. B. (2017) · Advances in neurobiology · doi:10.1007/978-3-319-58811-7_4 · Cited by 37
Unique Molecular Regulation of Higher-Order Prefrontal Cortical Circuits: Insights into the Neurobiology of Schizophrenia
Datta, D., & Arnsten, A. F. T. (2018) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.7b00505 · Cited by 38
Phosphodiesterases as Targets for Modulating T-Cell Responses
Bjørgo, E., Moltu, K., & Taskén, K. (2011) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-17969-3_15 · Cited by 36
Dopamine Receptor Excess and Mouse Madness
Snyder, S. H. (2006) · Neuron · doi:10.1016/j.neuron.2006.02.002 · Cited by 36
PDE Inhibitors for the Treatment of Schizophrenia
Snyder, G. L., & Vanover, K. E. (2017) · Advances in neurobiology · doi:10.1007/978-3-319-58811-7_14 · Cited by 35
PC12 cell model of inducible expression of mutant DISC1: new evidence for a dominant-negative mechanism of abnormal neuronal differentiation.
Pletnikov, M., Xu, Y.-Q., Ovanesov, M., Kamiya, A., Sawa, A., & Ross, C. (2007) · Neurosciences research · doi:10.1016/j.neures.2007.03.003 · Cited by 39
Disrupted-in-Schizophrenia-1 is essential for normal hypothalamic-pituitary-interrenal (HPI) axis function
Eachus, H., Bright, C., Cunliffe, V. T., Placzek, M., Wood, J., & Watt, P. J. (2017) · Human Molecular Genetics · doi:10.1093/hmg/ddx076 · Cited by 36
Currently recognized genes for schizophrenia: High‐resolution chromosome ideogram representation
Butler, M. G., McGuire, A., Masoud, H., & Manzardo, A. M. (2015) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.32391 · Cited by 35
Association of VSNL1 with schizophrenia, frontal cortical function, and biological significance for its gene product as a modulator of cAMP levels and neuronal morphology
Braunewell, K. H., Dwary, A. D., Richter, F., Trappe, K., Zhao, C., Giegling, I., Schönrath, K., & Rujescu, D. (2011) · Translational Psychiatry · doi:10.1038/tp.2011.20 · Cited by 36
Gene expression and association analyses of the phosphodiesterase 4B (PDE4B) gene in major depressive disorder in the Japanese population
Numata, S., Iga, J., Nakataki, M., Tayoshi, S., Taniguchi, K., Sumitani, S., Tomotake, M., Tanahashi, T., Itakura, M., Kamegaya, Y., et al. (2008) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30852 · Cited by 36
Ndel1, Nudel ( Noodle): Flexible in the cell?
Chansard, M., Hong, J., Park, Y., Park, S. K., & Nguyen, M. D. (2011) · Cytoskeleton · doi:10.1002/cm.20532 · Cited by 33
Sonic hedgehog functions upstream ofdisrupted-in-schizophrenia 1(disc1): implications for mental illness
Boyd, P. J., Cunliffe, V. T., Roy, S., & Wood, J. (2015) · Biology Open · doi:10.1242/bio.012005 · Cited by 34
NDE1 and GSK3β Associate with TRAK1 and Regulate Axonal Mitochondrial Motility: Identification of Cyclic AMP as a Novel Modulator of Axonal Mitochondrial Trafficking
Ogawa, F., Murphy, L. C., Malavasi, E. L. V., O’Sullivan, S. T., Torrance, H. S., Porteous, D. J., & Millar, J. K. (2016) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.5b00255 · Cited by 35
Self-citation
Endogenous Cell Type-Specific DISC1 Interactomes Reveal Protein Networks Associated to Neurodevelopmental Disorders
Wilkinson, B., Evgrafov, O., Zheng, D.-Q., Hartel, N. G., Knowles, J., Graham, N., Ichida, J., & Coba, M. (2018) · Biological Psychiatry · doi:10.1016/j.biopsych.2018.05.009 · Cited by 29
Altered phosphorylation, electrophysiology, and behavior on attenuation of PDE4B action in hippocampus
Campbell, S. L., van Groen, T., Kadish, I., Smoot, L. H. M., & Bolger, G. B. (2017) · BMC Neuroscience · doi:10.1186/s12868-017-0396-6 · Cited by 33
Primate disrupted-in-schizophrenia-1 (DISC1): High divergence of a gene for major mental illnesses in recent evolutionary history
Bord, L., Wheeler, J., Paek, M. J., Saleh, M., Lyons-Warren, A. M., Ross, C. A., Sawamura, N., & Sawa, A. (2006) · Neuroscience Research · doi:10.1016/j.neures.2006.07.010 · Cited by 34
Molecular mechanism of schizophrenia with reference to disrupted-in-schizophrenia 1 (DISC1)
Matsuzaki, S., & Tohyama, M. (2007) · Neurochemistry International · doi:10.1016/j.neuint.2007.06.018 · Cited by 34
Statistical epistasis and progressive brain change in schizophrenia: an approach for examining the relationships between multiple genes
Andreasen, N. C., Wilcox, M., Ho, B., Epping, E. A., Ziebell, S., Zeien, E., Weiss, B., & Wassink, T. H. (2011) · Molecular Psychiatry · doi:10.1038/mp.2011.108 · Cited by 34
Host–parasite interaction associated with major mental illness
Kano, S., Hodgkinson, C. A., Jones‐Brando, L. V., Eastwood, S. L., Ishizuka, K., Niwa, M., Choi, E. Y., Chang, D. J., Chen, Y., Velivela, S. D., et al. (2018) · Molecular Psychiatry · doi:10.1038/s41380-018-0217-z · Cited by 32
Novel N-indolylmethyl substituted olanzapine derivatives: their design, synthesis and evaluation as PDE4B inhibitors
Gorja, D. R., Mukherjee, S., Meda, C. L. T., Deora, G. S., Kumar, K. L., Jain, A., Chaudhari, G. H., Chennubhotla, K. S., Banote, R. K., Kulkarni, P., et al. (2013) · Organic & Biomolecular Chemistry · doi:10.1039/c3ob27424a · Cited by 33
Phosphodiesterase-4 inhibitors ameliorates cognitive deficits in deoxycorticosterone acetate induced hypertensive rats via cAMP/CREB signaling system
Sugin Lal Jabaris, S., Sumathy, H., Girish, R., Narayanan, S., Sugumar, M., Babu, C. S., Thanikachalam, S., & Thanikachalam, M. (2015) · Brain Research · doi:10.1016/j.brainres.2015.07.003 · Cited by 33
How has DISC1 enabled drug discovery?
Wang, Q., Jaaro-Peled, H., Sawa, A., & Brandon, N. (2008) · Molecular and cellular neurosciences · doi:10.1016/j.mcn.2007.10.006 · Cited by 36
Self-citation
The TRAX, DISC1, and GSK3 complex in mental disorders and therapeutic interventions
Weng, Y., Chien, T., Kuan, I., & Chern, Y. (2018) · Journal of Biomedical Science · doi:10.1186/s12929-018-0473-x · Cited by 32
Closing the translational gap between mutant mouse models and the clinical reality of psychotic illness
O’Tuathaigh, C. M. P., & Waddington, J. L. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2015.01.016 · Cited by 31
Cyclic nucleotide phosphodiesterases: potential therapeutic targets for alcohol use disorder
Wen, R.-T., Zhang, F.-F., & Zhang, H. (2018) · Psychopharmacology · doi:10.1007/s00213-018-4895-7 · Cited by 31
Phosphodiesterase-4D Knockdown in the Prefrontal Cortex Alleviates Memory Deficits and Synaptic Failure in Mouse Model of Alzheimer’s Disease
Shi, Y., Lv, J., Ling, C., Luo, G., Tao, M., Pan, J., Hu, X., Sheng, J., Zhang, S., Zhou, M., et al. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.722580 · Cited by 31
Phenotypic characterization of C57BL/6J mice carrying the Disc1 gene from the 129S6/SvEv strain
Juan, L.-W., Liao, C., Lai, W., Chang, C., Pei, J.-C., Wong, W.-R., Liu, C., Hwu, H., & Lee, L. (2013) · Brain Structure and Function · doi:10.1007/s00429-013-0577-8 · Cited by 34
Phosphodiesterase genes and antidepressant treatment response: A review
Esposito, K. F., Reierson, G. W., Luo, H. R., Wu, G. S., Licinio, J., & Wong, M. (2008) · Annals of Medicine · doi:10.1080/07853890802441169 · Cited by 31
Phosphodiesterase and psychiatric disorders: a two-sample Mendelian randomization study
Jiang, M., Yan, W., Zhang, Y., Lu, Z., Lu, T., Zhang, D., Li, J., & Wang, L. (2023) · Journal of Translational Medicine · doi:10.1186/s12967-023-04368-0 · Cited by 29
Differential function of phosphodiesterase families in the brain: gaining insights through the use of genetically modified animals
Kelly, M. P., & Brandon, N. J. (2009) · Progress in brain research · doi:10.1016/s0079-6123(09)17908-6 · Cited by 30
Self-citation
DISC 1 regulates expression of the neurotrophin VGF through the PI 3K/ AKT / CREB pathway
Rodríguez‐Seoane, C., Ramos, A., Korth, C., & Requena, J. R. (2015) · Journal of Neurochemistry · doi:10.1111/jnc.13258 · Cited by 30
Disrupted in Schizophrenia 1 Modulates Medial Prefrontal Cortex Pyramidal Neuron Activity Through cAMP Regulation of Transient Receptor Potential C and Small-Conductance K+ Channels
El-Hassar, L., Simen, A. A., Duque, A., Patel, K. D., Kaczmarek, L. K., Arnsten, A. F. T., & Yeckel, M. F. (2014) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.12.019 · Cited by 30
Phosphodiesterase‑4 inhibitors: a review of current developments (2013–2021)
Liu, Z., Liu, M., Cao, Z., Qiu, P., & Song, G. (2022) · Expert Opinion on Therapeutic Patents · doi:10.1080/13543776.2022.2026328 · Cited by 30
Comorbidity of substance abuse with other psychiatric disorders
Palomo, T., Archer, T., Kostrzewa, R. M., & Beninger, R. J. (2007) · Neurotoxicity Research · doi:10.1007/bf03033898 · Cited by 30
Risk genes for schizophrenia: Translational opportunities for drug discovery
Winchester, C. L., Pratt, J. A., & MORRIS, B. J. (2014) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2014.02.003 · Cited by 32
iCLIP identifies novel roles for SAFB1 in regulating RNA processing and neuronal function
Rivers, C. A., Idris, J., Scott, H. L., Rogers, M. F., Lee, Y., Gaunt, J. R., Phylactou, L. A., Curk, T., Campbell, C., Ule, J., et al. (2015) · BMC Biology · doi:10.1186/s12915-015-0220-7 · Cited by 28
Mitochondrial roles of the psychiatric disease risk factor DISC1.
Norkett, R., Modi, S., & Kittler, J. (2017) · Schizophrenia Research · doi:10.1016/j.schres.2016.12.025 · Cited by 25
β-Catenin Promoter ChIP-Chip Reveals Potential Schizophrenia and Bipolar Disorder Gene Network
Pedrosa, E., Shah, A., Tenore, C., Capogna, M., Villa, C., Guo, X., Zheng, D., & Lachman, H. M. (2010) · Journal of Neurogenetics · doi:10.3109/01677063.2010.495182 · Cited by 31
Molecular Characterization of Disrupted in Schizophrenia-1 Risk Variant S704C Reveals the Formation of Altered Oligomeric Assembly
Narayanan, S., Arthanari, H., Wolfe, M. S., & Wagner, G. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.271593 · Cited by 29
Mitotic activation of the DISC1-inducible cyclic AMP phosphodiesterase-4D9 (PDE4D9), through multi-site phosphorylation, influences cell cycle progression
Sheppard, C. L., Lee, L. C. Y., Hill, E. V., Henderson, D., Anthony, D. F., Houslay, D. M., Yalla, K. C., Cairns, L. S., Dunlop, A. J., Baillie, G. S., et al. (2014) · Cellular Signalling · doi:10.1016/j.cellsig.2014.04.023 · Cited by 28
Self-citation
The role of selective transport in neuronal polarization
Namba, T., Nakamuta, S., Funahashi, Y., & Kaibuchi, K. (2011) · Developmental Neurobiology · doi:10.1002/dneu.20876 · Cited by 30
Bassoon controls synaptic vesicle release via regulation of presynaptic phosphorylation and cAMP
Montenegro‐Venegas, C., Guhathakurta, D., Pina-Fernández, E., Andres‐Alonso, M., Plattner, F., Lazarevic, V., Gundelfinger, E. D., & Fejtová, A. (2022) · EMBO Reports · doi:10.15252/embr.202153659 · Cited by 28
Dissecting DISC1 function through protein-protein interactions.
Brandon, N. (2007) · Biochemical Society Transactions · doi:10.1042/bst0351283 · Cited by 27
Self-citation
Abnormal behavior in mice mutant for the Disc1 binding partner, Dixdc1
Kivimäe, S., Martin, P.-M., Kapfhamer, D., Ruan, Y., Heberlein, U., Rubenstein, J. L. R., & Cheyette, B. N. R. (2011) · Translational Psychiatry · doi:10.1038/tp.2011.41 · Cited by 27
Novel treatment strategies for schizophrenia from improved understanding of genetic risk
Morris, B., & Pratt, J. A. (2014) · Clinical Genetics · doi:10.1111/cge.12485 · Cited by 29
Now You See It, Now You Don't—Closing in on Allostasis and Developmental Basis of Psychiatric Disorders
Thompson, B. L., & Levitt, P. R. (2010) · Neuron · doi:10.1016/j.neuron.2010.02.010 · Cited by 27
Regulation of the cytoskeleton by Disrupted-in-Schizophrenia 1 (DISC1)
Wang, Q., & Brandon, N. J. (2011) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2011.06.004 · Cited by 29
Self-citation
Role of the PACAP–PAC1–DISC1 and PACAP–PAC1–Stathmin1 Systems in Schizophrenia and Bipolar Disorder: Novel Treatment Mechanisms?
Katayama, T., Hattori, T., Yamada, K., Matsuzaki, S., & Tohyama, M. (2009) · Pharmacogenomics · doi:10.2217/pgs.09.147 · Cited by 27
The neurobiology of schizophrenia: new leads and avenues for treatment
Bray, N. J., Leweke, F. M., Kapur, S., & Meyer‐Lindenberg, A. (2010) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2010.09.008 · Cited by 26
Expression of DISC1-Interactome Members Correlates with Cognitive Phenotypes Related to Schizophrenia
Rampino, A., Walker, R., Torrance, H., Anderson, S. M., Fazio, L., Giorgio, A. D., Taurisano, P., Gelao, B., Romano, R., Masellis, R., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0099892 · Cited by 29
Self-citation
Role of DISC1 Interacting Proteins in Schizophrenia Risk from Genome‐Wide Analysis of Missense SNPs
Costas, J., Suárez-Rama, J. J., Carrera, N., Paz, E., Páramo, M., Agra, S., Brenlla, J., Ramos‐Ríos, R., & Arrojo, M. (2013) · Annals of Human Genetics · doi:10.1111/ahg.12037 · Cited by 26
Genomic regions affecting backfat thickness and cannon bone circumference identified by genome-wide association study in a Duroc pig population
Okumura, N., Matsumoto, T., Hayashi, T., Hirose, K., Fukawa, K., Itou, T., Uenishi, H., Mikawa, S., & Awata, T. (2012) · Animal Genetics · doi:10.1111/age.12018 · Cited by 26
Missense mutation in DISC1 C-terminal coiled-coil has GSK3β signaling and sex-dependent behavioral effects in mice
Dachtler, J., Elliott, C., Rodgers, R., Baillie, G. S., & Clapcote, S. (2016) · Scientific Reports · doi:10.1038/srep18748 · Cited by 26
Self-citation
DISC1 regulates N-methyl-D-aspartate receptor dynamics: abnormalities induced by a Disc1 mutation modelling a translocation linked to major mental illness
Malavasi, E. L. V., Economides, K. D., Grünewald, E., Makedonopoulou, P., Gautier, P. E., Mackie, S., Murphy, L. C., Murdoch, H., Crummie, D., Ogawa, F., et al. (2018) · Translational Psychiatry · doi:10.1038/s41398-018-0228-1 · Cited by 26
Self-citation
Chronic Nicotine Doses Down-Regulate PDE4 Isoforms that Are Targets of Antidepressants in Adolescent Female Rats
Polesskaya, O., Smith, R. F., & Fryxell, K. J. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.03.038 · Cited by 26
1,2,3-Triazoles derived from olanzapine: their synthesis via an ultrasound assisted CuAAC method and evaluation as inhibitors of PDE4B
Nallapati, S. B., Sreenivas, B. Y., Bankala, R., Parsa, K. V. L., Shivashankar, S., Mukkanti, K., & Pal, M. (2015) · RSC Advances · doi:10.1039/c5ra20380e · Cited by 25
Abnormal wake/sleep pattern in a novel gain-of-function model of DISC1
Jaaro-Peled, H., Altimus, C. M., LeGates, T. A., Cash-Padgett, T. V., Zoubovsky, S. P., Hikida, T., Ishizuka, K., Hattar, S. S., Mongrain, V., & Sawa, A. (2016) · Neuroscience Research · doi:10.1016/j.neures.2016.06.006 · Cited by 25
Copy number variation detection using SNP genotyping arrays in three Chinese pig breeds
Dong, K., Pu, Y., Yao, N., Shu, G., Liu, X., He, X., Zhao, Q., Guan, W., & Ma, Y. (2015) · Animal Genetics · doi:10.1111/age.12247 · Cited by 26
Following the genes: a framework for animal modeling of psychiatric disorders
Mitchell, K. J., Huang, Z. J., Moghaddam, B., & Sawa, A. (2011) · BMC Biology · doi:10.1186/1741-7007-9-76 · Cited by 27
Genetic Association of Phosphodiesterases With Human Cognitive Performance
Gurney, M. E. (2019) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2019.00022 · Cited by 25
Disc1 Variation Leads to Specific Alterations in Adult Neurogenesis
Chandran, J. S., Kazanis, I., Clapcote, S. J., Ogawa, F., Millar, J. K., Porteous, D. J., & ffrench‐Constant, C. (2014) · PLoS ONE · doi:10.1371/journal.pone.0108088 · Cited by 24
Self-citation
Reshaping cAMP nanodomains through targeted disruption of compartmentalised phosphodiesterase signalosomes
Blair, C. M., & Baillie, G. S. (2019) · Biochemical Society Transactions · doi:10.1042/bst20190252 · Cited by 24
Self-citation
Phosphodiesterase-4 Inhibition in Parkinson’s Disease: Molecular Insights and Therapeutic Potential
Roy, D., Balasubramanian, S., Krishnamurthy, P. T., Sola, P., & Rymbai, E. (2023) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-023-01349-1 · Cited by 24
DISC1 Pathway in Brain Development: Exploring Therapeutic Targets for Major Psychiatric Disorders
Kamiya, A., Sedlak, T. W., & Pletnikov, M. V. (2012) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2012.00025 · Cited by 24
Co-ordinated action of DISC1, PDE4B and GSK3β in modulation of cAMP signalling
Carlyle, B. C., Mackie, S., CHRISTIE, S., Millar, J. K., & Porteous, D. J. (2011) · Molecular Psychiatry · doi:10.1038/mp.2011.17 · Cited by 24
Self-citation
Schizophrenia risk genes: Implications for future drug development and discovery
O’Connell, G., Lawrie, S. M., McIntosh, A. M., & Hall, J. (2010) · Biochemical Pharmacology · doi:10.1016/j.bcp.2010.11.009 · Cited by 24
Chemical informatics uncovers a new role for moexipril as a novel inhibitor of cAMP phosphodiesterase-4 (PDE4)
Cameron, R. T., Coleman, R. G., Day, J. P., Yalla, K. C., Houslay, M. D., Adams, D. R., Shoichet, B. K., & Baillie, G. S. (2013) · Biochemical Pharmacology · doi:10.1016/j.bcp.2013.02.026 · Cited by 23
Self-citation
DISC1 Protein Regulates γ-Aminobutyric Acid, Type A (GABAA) Receptor Trafficking and Inhibitory Synaptic Transmission in Cortical Neurons*
Wei, J., Graziane, N., Gu, Z.-L., & Yan, Z. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.656173 · Cited by 22
Chromosome abnormalities, mental retardation and the search for genes in bipolar disorder and schizophrenia
Blackwood, D., Thiagarajah, T., Malloy, P., Pickard, B. S., & Muir, W. J. (2008) · Neurotoxicity Research · doi:10.1007/bf03033803 · Cited by 24
Self-citation
DISCopathies: Brain Disorders Related to DISC1 Dysfunction
Korth, C. (2009) · Reviews in the Neurosciences · doi:10.1515/revneuro.2009.20.5-6.321 · Cited by 29
The effects of DISC1 risk variants on brain activation in controls, patients with bipolar disorder and patients with schizophrenia.
Chakirova, G., Whalley, H., Thomson, P., Hennah, W., Moorhead, T. W., Welch, K., Giles, S., Hall, J., Johnstone, E., Lawrie, S., et al. (2011) · Psychiatry Research · doi:10.1016/j.pscychresns.2011.01.015 · Cited by 28
Self-citation
Stem Cell-Derived Neurons in the Development of Targeted Treatment for Schizophrenia and Bipolar Disorder
Watmuff, B., Liu, B., & Karmacharya, R. (2017) · Pharmacogenomics · doi:10.2217/pgs-2016-0187 · Cited by 22
Nde1 and Ndel1: Outstanding Mysteries in Dynein-Mediated Transport
Garrott, S. R., Gillies, J. P., & DeSantis, M. E. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.871935 · Cited by 21
Associations of ATF4 gene polymorphisms with schizophrenia in male patients
Qu, M., Tang, F.-L., Wang, L.-F., Yan, H., Han, Y.-H., Yan, J., Yue, W., & Zhang, D. (2008) · American Journal of Medical Genetics Part B: Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30675 · Cited by 23
Venlafaxine increases cell proliferation and regulates DISC1, PDE4B and NMDA receptor 2B expression in the hippocampus in chronic mild stress mice
Zhang, X., Li, X., Li, M., Ren, J., Yun, K., An, Y., Lin, L., & Zhang, H. (2015) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2015.02.044 · Cited by 24
A competitive PCR assay confirms the association of a copy number variation in the VIPR2 gene with schizophrenia in Han Chinese
Yuan, J., Jin, C., Sha, W., Zhou, Z., Zhang, F., Wang, M., Wang, J., Li, J., Feng, X., Yu, S., et al. (2014) · Schizophrenia Research · doi:10.1016/j.schres.2014.04.004 · Cited by 23
Strong Evidence for a Novel Schizophrenia Risk Locus on Chromosome 1p31.1 in Homogeneous Pedigrees From Tamil Nadu, India
Holliday, E. G., Nyholt, D. R., Tirupati, S., John, S., Ramachandran, P., Mangala, R., Ramadoss, A. J., Jeyagurunathan, A., Kottiswaran, S., Smith, H. J., et al. (2008) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2008.08030442 · Cited by 22
Evidence of association of the DISC1 interactome gene set with schizophrenia from GWAS
Facal, F., & Costas, J. (2019) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2019.109729 · Cited by 22
DNA sequence-level analyses reveal potential phenotypic modifiers in a large family with psychiatric disorders
Ryan, N., Lihm, J., Kramer, M., McCarthy, S., Morris, S. W., Arnau‐Soler, A., Davies, G., Duff, B. J., Ghiban, E., Hayward, C., et al. (2018) · Molecular Psychiatry · doi:10.1038/s41380-018-0087-4 · Cited by 22
Self-citation
Dysregulated Signaling at Postsynaptic Density: A Systematic Review and Translational Appraisal for the Pathophysiology, Clinics, and Antipsychotics’ Treatment of Schizophrenia
de Bartolomeis, A., Vellucci, L., Simone, G. D., Mazza, B., Barone, A., & Ciccarelli, M. (2023) · Cells · doi:10.3390/cells12040574 · Cited by 22
No association of Disrupted‐in‐Schizophrenia‐1 variation with prefrontal function in patients with schizophrenia and bipolar disorder
Prata, D., Mechelli, A., Picchioni, M., Fu, C. H. Y., Kane, F., Kalidindi, S., Mcdonald, C., Kravariti, E., Toulopoulou, T., Bramon, E., et al. (2011) · Genes, Brain and Behavior · doi:10.1111/j.1601-183x.2010.00665.x · Cited by 24
Serotonergic hyperinnervation and effective serotonin blockade in an FGF receptor developmental model of psychosis
Klejbor, I., Kucinski, A. J., Wersinger, S. R., Corso, T. D., Spodnik, J. H., Dziewíatkowski, J., Moryś, J., Hesse, R. A., Rice, K. C., Miletich, R. S., et al. (2009) · Schizophrenia Research · doi:10.1016/j.schres.2009.06.006 · Cited by 21
Phosphodiesterase signaling system is disrupted in the cerebella of subjects with schizophrenia, bipolar disorder, and major depression
Fatemi, S. H., Folsom, T. D., Reutiman, T. J., & Vazquez, G. (2010) · Schizophrenia Research · doi:10.1016/j.schres.2010.02.1055 · Cited by 21
Quantitative Proteomics of Synaptosomal Fractions in a Rat Overexpressing Human DISC1 Gene Indicates Profound Synaptic Dysregulation in the Dorsal Striatum
Sialana, F. J., Wang, A.-L., Fazari, B., Kristofova, M., Smidak, R., Trossbach, S. V., Korth, C., Huston, J., Silva, M. A. D. S., & Lubec, G. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00026 · Cited by 19
Chapter 1 Potential CNS Applications for Phosphodiesterase Enzyme Inhibitors
Brandon, N. J., & Rotella, D. P. (2007) · Annual reports in medicinal chemistry · doi:10.1016/s0065-7743(07)42001-2 · Cited by 21
Self-citation
N termini of apPDE4 isoforms are responsible for targeting the isoforms to different cellular membranesPreprint
Jang, D., Park, S., Lee, J.-A., Lee, C., Chae, Y.-S., Park, H., Kim, M., Choi, S.-L., Lee, N., Kim, H., et al. (2010) · Learning & Memory · doi:10.1101/lm.1899410 · Cited by 21
Antipsychotic Induced Alteration of Growth and Proteome of Rat Neural Stem Cells
Ahmed, E. U., Ahmed, S., Ukai, W., Matsumoto, I., Kemp, A. H., McGregor, I. S., & Kashem, M. A. (2012) · Neurochemical Research · doi:10.1007/s11064-012-0768-3 · Cited by 20
Inherited balanced translocation t(9;17)(q33.2;q25.3) concomitant with a 16p13.1 duplication in a patient with schizophrenia
Fullston, T., Gabb, B., Callen, D. F., Ullmann, R., Woollatt, E., Bain, S. M., Ropers, H. H., Cooper, M. N., Chandler, D., Carter, K. W., et al. (2011) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.31157 · Cited by 23
Structure and evolutionary history of DISC1
Sánchez‐Pulido, L., & Ponting, C. P. (2011) · Human Molecular Genetics · doi:10.1093/hmg/ddr374 · Cited by 20
Phosphodiesterase Inhibition to Target the Synaptic Dysfunction in Alzheimer’s Disease
Bales, K. R., Plath, N., Svenstrup, N., & Menniti, F. S. (2010) · Topics in medicinal chemistry · doi:10.1007/7355_2010_8 · Cited by 22
The Shock of the New: Progress in Schizophrenia Genomics
Moore, S., Kelleher, E., & Corvin, A. P. (2011) · Current Genomics · doi:10.2174/138920211797904089 · Cited by 21
A Disrupted-in-Schizophrenia 1 Gene Variant is Associated with Clinical Symptomatology in Patients with First-Episode Psychosis
Vázquez-Bourgon, J., Mata, I., Roiz-Santiañez, R., Ayesa-Arriola, R., Suárez-Pinilla, P., Tordesillas-Gutiérrez, D., Vázquez-Barquero, J., & Crespo-Facorro, B. (2014) · Psychiatry Investigation · doi:10.4306/pi.2014.11.2.186 · Cited by 20
Towards a virtual fly brain
Armstrong, J. D., & Hemert, J. I. V. (2009) · Philosophical Transactions of the Royal Society A Mathematical Physical and Engineering Sciences · doi:10.1098/rsta.2008.0308 · Cited by 19
Brain function, structure and genomic data are linked but show different sensitivity to duration of illness and disease stage in schizophrenia
Luo, N., Tian, L., Calhoun, V. D., Chen, J., Lin, D., Vergara, V. M., Rao, S., Yang, J., Zhuo, C., Xu, Y. J., et al. (2019) · NeuroImage Clinical · doi:10.1016/j.nicl.2019.101887 · Cited by 20
Neuregulin-1 Regulates Cortical Inhibitory Neuron Dendrite and Synapse Growth through DISC1
Unda, B. K., Kwan, V., & Singh, K. K. (2016) · Neural Plasticity · doi:10.1155/2016/7694385 · Cited by 19

Authors: Millar, J. K., Pickard, B. S., Mackie, S., James, R., Christie, S., Buchanan, S. R., Malloy, M. P., Chubb, J. E., Huston, E., Baillie, G. S., Thomson, P. A., Hill, E. V., Brandon, N. J., Rain, J.-C., Camargo, L. M., Whiting, P. J., Houslay, M. D., Blackwood, D. H. R., Muir, W. J., & Porteous, D. J.
Affiliations: Royal Edinburgh Hospital (GB)
Medical Genetics Section, Molecular Medicine Centre, University of Edinburgh, Edinburgh EH4 2XU, UK.
Corresponding author: Millar, J. Kirsty
ORCID: James, Rachel
Baillie, George S.
Thomson, Pippa A.
Brandon, Nicholas J.
Rain, Jean-Christophe
Camargo, L. Miguel
Whiting, Paul J.
Houslay, Miles D.
Blackwood, Douglas H. R.
Porteous, David J.
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 2005-11-18
Volume: 310
Issue: 5751
Pages: 1187-1191
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.1112915
OpenAlex: W2105051672
Cited by: 648
References: 20
Citations by year: 2026: 7 · 2025: 7 · 2024: 12 · 2023: 11 · 2022: 14 · 2021: 13 · 2020: 14 · 2019: 19 · 2018: 21 · 2017: 24 · 2016: 28 · 2015: 47 · 2014: 39 · 2013: 24 · 2012: 35
FWCI: 20.82
Type: journal article
Language: en
Open access: closed
Locations: Science (publishedVersion)
PubMed (publishedVersion)
UCL Discovery (University College London) (submittedVersion)
Funders: Wellcome Trust
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Phosphodiesterase function and regulation
Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Tyrosine Phosphatases
Keywords: DISC1, PDE4B, schizophrenia, cAMP signaling, phosphodiesterase 4, balanced translocation, protein-protein interaction, second messengers, genetic susceptibility, chronic mental illness
MeSH terms: Cyclic AMP, Adult, Affective Disorders, Psychotic, Animals, Cell Line, Chromosomes, Human, Pair 1, Chromosomes, Human, Pair 16, Enzyme Activation, Humans, Male, Nerve Tissue Proteins, Protein Binding, Schizophrenia, Translocation, Genetic, 3',5'-Cyclic-AMP Phosphodiesterases, Signal Transduction, Cadherins, Genetic Predisposition to Disease, Rats, Cyclic Nucleotide Phosphodiesterases, Type 4

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

DISC1 and PDE4B Are Interacting Genetic Factors in Schizophrenia That Regulate cAMP Signaling

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks