The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.
Apolipoprotein L-I Promotes Trypanosome Lysis by Forming Pores in Lysosomal Membranes
Abstract
Apolipoprotein L-I is the trypanolytic factor of human serum. Here we show that this protein contains a membrane pore-forming domain functionally similar to that of bacterial colicins, flanked by a membrane-addressing domain. In lipid bilayer membranes, apolipoprotein L-I formed anion channels. In Trypanosoma brucei , apolipoprotein L-I was targeted to the lysosomal membrane and triggered depolarization of this membrane, continuous influx of chloride, and subsequent osmotic swelling of the lysosome until the trypanosome lysed.
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Cites
X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death
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Apolipoprotein L-I is the trypanosome lytic factor of human serum
Vanhamme, L., Paturiaux-Hanocq, F., Poelvoorde, P., Nolan, D. P., Lins, L., Van Den Abbeele, J., Pays, A., Tebabi, P., Van Xong, H., Jacquet, A., et al. (2003) · Nature · doi:10.1038/nature01461 · Cited by 500
Self-citationApolipoprotein L, a New Human High Density Lipoprotein Apolipoprotein Expressed by the Pancreas
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Real-time optical imaging of naturally evoked electrical activity in intact frog brain
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The Human Apolipoprotein L Gene Cluster: Identification, Classification, and Sites of Distribution
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Evidence for a Trypanosoma brucei Lipoprotein Scavenger Receptor
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Cited by
Association of Trypanolytic ApoL1 Variants with Kidney Disease in African Americans
Genovese, G., Friedman, D. J., Ross, M. D., Lecordier, L., Uzureau, P., Freedman, B. I., Bowden, D. W., Langefeld, C. D., Oleksyk, T. K., Uscinski Knob, A. L., et al. (2010) · Science · doi:10.1126/science.1193032 · Cited by 2,028
Self-citationDetecting Natural Selection in Genomic Data
Vitti, J. J., Grossman, S. R., & Sabeti, P. C. (2013) · Annual Review of Genetics · doi:10.1146/annurev-genet-111212-133526 · Cited by 694
The trypanosome flagellar pocket
Field, M. C., & Carrington, M. (2009) · Nature Reviews Microbiology · doi:10.1038/nrmicro2221 · Cited by 277
Brites, F., Martin, M., Guillas, I., & Kontush, A. (2017) · BBA Clinical · doi:10.1016/j.bbacli.2017.07.002 · Cited by 265
Hwang, Y., Kim, J., Shin, J.-Y., Kim, J.-I., Seo, J.-S., Webster, M. J., Lee, D., & Kim, S. (2013) · Translational Psychiatry · doi:10.1038/tp.2013.94 · Cited by 189
Metadata
- Authors
- Pérez-Morga, D., Vanhollebeke, B., Paturiaux-Hanocq, F., Nolan, D. P., Lins, L., Homblé, F., Vanhamme, L., Tebabi, P., Pays, A., Poelvoorde, P., Jacquet, A., Brasseur, R., & Pays, E.
- Venue
- Science
- Published
- 2005-07-15
- Volume
- 309
- Issue
- 5733
- Pages
- 469-472
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2149616337
- Cited by
- 339
- References
- 19
- FWCI
- 8.07
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Apolipoprotein L-I Promotes Trypanosome Lysis by Forming Pores in Lysosomal Membranes. https://app.cochat.ai/papers/10.1126/science.1114566
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- Pérez-Morga, D., Vanhollebeke, B., Paturiaux-Hanocq, F., Nolan, D. P., Lins, L., Homblé, F., Vanhamme, L., Tebabi, P., Pays, A., Poelvoorde, P., Jacquet, A., Brasseur, R., & Pays, E. (2005). Apolipoprotein L-I Promotes Trypanosome Lysis by Forming Pores in Lysosomal Membranes. Science. https://doi.org/10.1126/science.1114566
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