Cited by 189Schizophrenia research and treatmentTryptophan and brain disordersNeuroinflammation and Neurodegeneration Mechanisms

Gene expression profiling by mRNA sequencing reveals increased expression of immune/inflammation-related genes in the hippocampus of individuals with schizophrenia

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Hwang, Y, Kim, J, Shin, J-Y, Kim, J-II, Seo, J-S, Webster, M J, Lee, D, Kim, S·2013·Translational Psychiatry

Abstract

Whole-genome expression profiling in postmortem brain tissue has recently provided insight into the pathophysiology of schizophrenia. Previous microarray and RNA-Seq studies identified several biological processes including synaptic function, mitochondrial function and immune/inflammation response as altered in the cortex of subjects with schizophrenia. Now using RNA-Seq data from the hippocampus, we have identified 144 differentially expressed genes in schizophrenia cases as compared with unaffected controls. Immune/inflammation response was the main biological process over-represented in these genes. The upregulation of several of these genes, IFITM1, IFITM2, IFITM3, APOL1 (Apolipoprotein L1), ADORA2A (adenosine receptor 2A), IGFBP4 and CD163 were validated in the schizophrenia subjects using data from the SNCID database and with quantitative RT-PCR. We identified a co-expression module associated with schizophrenia that includes the majority of differentially expressed genes related to immune/inflammation response as well as with the density of parvalbumin-containing neurons in the hippocampus. The results indicate that abnormal immune/inflammation response in the hippocampus may underlie the pathophysiology of schizophrenia and may be associated with abnormalities in the parvalbumin-containing neurons that lead to the cognitive deficits of the disease.

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  • Reduced parvalbumin interneuron density in schizophrenia patients is associated with two modules of genes differentially expressed compared with healthy subjects, including many immune/inflammation-related genes.

    “A genome-wide profiling and immunohistological study revealed that reduced PVI density in schizophrenia patients is associated with two modules of genes differentially expressed in patients compared to healthy subjects, among which are many immune/inflammation-related genes (Hwang et al., 2013).”

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Authors
Hwang, Y., Kim, J., Shin, J.-Y., Kim, J.-I., Seo, J.-S., Webster, M. J., Lee, D., & Kim, S.
Affiliations
  • Korea Advanced Institute of Science and Technology (KR)
  • Seoul National University (KR)
  • Stanley Medical Research Institute (US)
Corresponding author
  • Lee, D
  • Kim, S
Venue
Translational Psychiatry
Published
2013-10-29
Volume
3
Issue
10
Pages
e321-e321
ISSN
2158-3188 (ISSN-L)
OpenAlex
W2012356934
Cited by
189
References
84
Citations by year
2026: 8 · 2025: 9 · 2024: 15 · 2023: 15 · 2022: 22 · 2021: 11 · 2020: 16 · 2019: 12 · 2018: 18 · 2017: 18 · 2016: 13 · 2015: 19 · 2014: 11 · 2013: 1
FWCI
10.39
Type
journal article
Language
en
Open access
Locations
  • Translational Psychiatry (publishedVersion, cc-by-nc-nd)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-nd)
  • PubMed Central (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
  • Seoul National University Open Repository (Seoul National University) (submittedVersion)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
  • Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords
schizophrenia, hippocampus, differentially expressed genes, IFITM1, IFITM2, IFITM3, APOL1, adenosine A2A receptor, IGFBP-4, CD163, cognitive impairment, postmortem brain, schizophrenia pathophysiology
MeSH terms
Apolipoprotein L1, CD163 Antigen, Adult, Antigens, Differentiation, Apolipoproteins, Female, Hippocampus, Humans, Inflammation, Lipoproteins, HDL, Male, Membrane Proteins, Middle Aged, Receptors, Cell Surface, RNA, Messenger, Schizophrenia, Antigens, Differentiation, Myelomonocytic, Antigens, CD, Up-Regulation, Case-Control Studies, RNA-Binding Proteins, Insulin-Like Growth Factor Binding Protein 4, Reverse Transcriptase Polymerase Chain Reaction, Oligonucleotide Array Sequence Analysis, Gene Expression Profiling, Receptor, Adenosine A2A

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