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Movement of Eukaryotic mRNAs Between Polysomes and Cytoplasmic Processing Bodies
Open accessAbstract
Eukaryotic cells contain nontranslating messenger RNA concentrated in P-bodies, which are sites where the mRNA can be decapped and degraded. We present evidence that mRNA molecules within yeast P-bodies can also return to translation. First, inhibiting delivery of new mRNAs to P-bodies leads to their disassembly independent of mRNA decay. Second, P-bodies decline in a translation initiation–dependent manner during stress recovery. Third, reporter mRNAs concentrate in P-bodies when translation initiation is blocked and resume translation and exit P-bodies when translation is restored. Fourth, stationary phase yeast have large P-bodies containing mRNAs that reenter translation when growth resumes. The reciprocal movement of mRNAs between polysomes and P-bodies is likely to be important in the control of mRNA translation and degradation. Moreover, the presence of related proteins in P-bodies and maternal mRNA storage granules suggests this mechanism is widely adapted for mRNA storage.
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Cited by
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Valencia-Sanchez, M. A., Liu, J., Hannon, G. J., & Parker, R. (2006) · Genes & Development · doi:10.1101/gad.1399806 · Cited by 2,060
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Metadata
- Authors
- Brengues, M., Teixeira, D., & Parker, R.
- Venue
- Science
- Published
- 2005-10-21
- Volume
- 310
- Issue
- 5747
- Pages
- 486-489
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1964628768
- Cited by
- 794
- References
- 0
- FWCI
- 21.67
- Type
- journal article
- Language
- en
- Open access
- green
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