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Spatial Coordination of Spindle Assembly by Chromosome-Mediated Signaling Gradients
Abstract
During cell division, chromosomes are distributed to daughter cells by the mitotic spindle. This system requires spatial cues to reproducibly self-organize. We report that such cues are provided by chromosome-mediated interaction gradients between the small guanosine triphosphatase (GTPase) Ran and importin-β. This produces activity gradients that determine the spatial distribution of microtubule nucleation and stabilization around chromosomes and that are essential for the self-organization of microtubules into a bipolar spindle.
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Citations
Cited by
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Merindol, R., & Walther, A. (2017) · Chemical Society Reviews · doi:10.1039/c6cs00738d · Cited by 533
The Aurora kinase family in cell division and cancer
Vader, G., & Lens, S. M. A. (2008) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2008.07.003 · Cited by 417
Branching Microtubule Nucleation in Xenopus Egg Extracts Mediated by Augmin and TPX2
Petry, S., Groen, A. C., Ishihara, K., Mitchison, T. J., & Vale, R. D. (2013) · Cell · doi:10.1016/j.cell.2012.12.044 · Cited by 375
Metadata
- Authors
- Caudron, M., Bunt, G., Bastiaens, P., & Karsenti, E.
- Venue
- Science
- Published
- 2005-08-26
- Volume
- 309
- Issue
- 5739
- Pages
- 1373-1376
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2065600921
- Cited by
- 301
- References
- 0
- FWCI
- 11.25
- Type
- journal article
- Language
- en
- Open access
- closed
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- Caudron, M., Bunt, G., Bastiaens, P., & Karsenti, E. (2005). Spatial Coordination of Spindle Assembly by Chromosome-Mediated Signaling Gradients. Science. https://doi.org/10.1126/science.1115964
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