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SMEDWI-2 Is a PIWI-Like Protein That Regulates Planarian Stem Cells
Abstract
We have identified two genes, smedwi-1 and smedwi-2 , expressed in the dividing adult stem cells (neoblasts) of the planarian Schmidtea mediterranea . Both genes encode proteins that belong to the Argonaute/PIWI protein family and that share highest homology with those proteins defined by Drosophila PIWI. RNA interference (RNAi) of smedwi-2 blocks regeneration, even though neoblasts are present, irradiation-sensitive, and capable of proliferating in response to wounding; smedwi-2(RNAi) neoblast progeny migrate to sites of cell turnover but, unlike normal cells, fail at replacing aged tissue. We suggest that SMEDWI-2 functions within dividing neoblasts to support the generation of cells that promote regeneration and homeostasis.
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Cited by
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Aravin, A., Gaidatzis, D., Pfeffer, S., Lagos-Quintana, M., Landgraf, P., Iovino, N., Morris, P., Brownstein, M. J., Kuramochi-Miyagawa, S., Nakano, T., et al. (2006) · Nature · doi:10.1038/nature04916 · Cited by 1,516
The Piwi-piRNA Pathway Provides an Adaptive Defense in the Transposon Arms Race
Aravin, A. A., Hannon, G. J., & Brennecke, J. (2007) · Science · doi:10.1126/science.1146484 · Cited by 1,096
Comparative Aspects of Animal Regeneration
Brockes, J. P., & Kumar, A. (2008) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.24.110707.175336 · Cited by 490
Bridging the regeneration gap: Genetic insights from diverse animal models
Alvarado, A. S., & Tsonis, P. A. (2006) · Nature Reviews Genetics · doi:10.1038/nrg1923 · Cited by 467
Cell type transcriptome atlas for the planarian Schmidtea mediterranea
Fincher, C. T., Wurtzel, O., de Hoog, T., Kravarik, K. M., & Reddien, P. W. (2018) · Science · doi:10.1126/science.aaq1736 · Cited by 436
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Metadata
- Authors
- Reddien, P. W., Oviedo, N. J., Jennings, J. R., Jenkin, J. C., & Alvarado, A. S.
- Venue
- Science
- Published
- 2005-11-25
- Volume
- 310
- Issue
- 5752
- Pages
- 1327-1330
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2074658822
- Cited by
- 627
- References
- 0
- FWCI
- 7.38
- Type
- journal article
- Language
- en
- Open access
- closed
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- Reddien, P. W., Oviedo, N. J., Jennings, J. R., Jenkin, J. C., & Alvarado, A. S. (2005). SMEDWI-2 Is a PIWI-Like Protein That Regulates Planarian Stem Cells. Science. https://doi.org/10.1126/science.1116110
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