Cited by 1,096Chromosomal and Genetic VariationsRNA Interference and Gene DeliveryPlant Molecular Biology Research

The Piwi-piRNA Pathway Provides an Adaptive Defense in the Transposon Arms Race

Aravin, Alexei A., Hannon, Gregory J., Brennecke, Julius·2007·Science

Abstract

Increasingly complex networks of small RNAs act through RNA-interference (RNAi) pathways to regulate gene expression, to mediate antiviral responses, to organize chromosomal domains, and to restrain the spread of selfish genetic elements. Historically, RNAi has been defined as a response to double-stranded RNA. However, some small RNA species may not arise from double-stranded RNA precursors. Yet, like microRNAs and small interfering RNAs, such species guide Argonaute proteins to silencing targets through complementary base-pairing. Silencing can be achieved by corecruitment of accessory factors or through the activity of Argonaute itself, which often has endonucleolytic activity. As a specific and adaptive regulatory system, RNAi is used throughout eukarya, which indicates a long evolutionary history. A likely function of RNAi throughout that history is to protect the genome from both pathogenic and parasitic invaders.

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Crossref · 10.1126/science.1146484

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38 of 38 references verified0 citation errors · 0 not checkable

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  • Piwi-interacting RNAs associate with germline-expressed Piwi proteins and have roles in transposon silencing and genome methylation.

    “Piwi-interacting RNAs (piRNAs) associate with a germlineexpressed clade of argonaute proteins, known as Piwis 26 , and have a role in transposon silencing and genome methylation 26 .”

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Authors
Aravin, A. A., Hannon, G. J., & Brennecke, J.
Affiliations
Howard Hughes Medical Institute (US)
Corresponding author
  • Aravin, Alexei A.
  • Hannon, Gregory J.
  • Brennecke, Julius
Venue
Science
Published
2007-11-02
Volume
318
Issue
5851
Pages
761-764
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
OpenAlex
W2046318418
Cited by
1,096
References
38
Citations by year
2026: 28 · 2025: 43 · 2024: 37 · 2023: 32 · 2022: 41 · 2021: 45 · 2020: 42 · 2019: 56 · 2018: 62 · 2017: 46 · 2016: 53 · 2015: 78 · 2014: 76 · 2013: 68 · 2012: 74
FWCI
6.79
Type
journal article
Language
en
Open access
closed
Locations
  • Science (publishedVersion)
  • PubMed (publishedVersion)
  • Cold Spring Harbor Laboratory Institutional Repository (Cold Spring Harbor Laboratory) (acceptedVersion)
  • CaltechAUTHORS (California Institute of Technology) (submittedVersion)
Topics
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Chromosomal and Genetic Variations
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Molecular Biology Research
Keywords
RNA interference, transposable elements, small RNA, Argonaute proteins, genome defense, selfish genetic elements, gene silencing
MeSH terms
Adaptation, Biological, Animals, Base Sequence, DNA Transposable Elements, Molecular Sequence Data, Proteins, RNA-Binding Proteins, Evolution, Molecular, Gene Silencing, Drosophila Proteins, RNA, Small Interfering, RNA-Induced Silencing Complex, Argonaute Proteins

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